All Outputs (4)

Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors (2016)
Journal Article
Russo, G., Grumetto, L., Barbato, F., Vistoli, G., & Pedretti, A. (2017). Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors. European Journal of Phar

The present study proposes a method for an in silico calculation of phospholipophilicity. Phospholipophilicity is intended as the measure of analyte affinity for phospholipids; it is currently assessed by HPLC measures of analyte retention on phospha... Read More about Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors.

Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood–Brain Barrier Permeation of Drugs (2016)
Journal Article
Grumetto, L., Russo, G., & Barbato, F. (2016). Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood–Brain Barrier Permeation of Drugs. Molecular Pharmaceutics, 13(8), 2808-2816. https://doi.org/1

The affinity indexes for phospholipids (log kWIAM) for 42 compounds were measured by high performance liquid chromatography (HPLC) on two different phospholipid-based stationary phases (immobilized artificial membrane, IAM), i.e., IAM.PC.MG and IAM.P... Read More about Immobilized Artificial Membrane HPLC Derived Parameters vs PAMPA-BBB Data in Estimating in Situ Measured Blood–Brain Barrier Permeation of Drugs.

Development and Validation of a LC-FD Method for the Simultaneous Determination of Eight Bisphenols in Soft Drinks (2016)
Journal Article
Russo, G., Barbato, F., & Grumetto, L. (2016). Development and Validation of a LC-FD Method for the Simultaneous Determination of Eight Bisphenols in Soft Drinks. Food Analytical Methods, 9(10), 2732-2740. https://doi.org/10.1007/s12161-016-0458-x

Bisphenol A (BPA) is a chemical widely used as a monomer in the production of polymers of plastics. It acts as an endocrine-disrupting agent and thus its contaminations of food and beverage should be carefully monitored in order to assess consumers’... Read More about Development and Validation of a LC-FD Method for the Simultaneous Determination of Eight Bisphenols in Soft Drinks.

Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption (2016)
Journal Article
Grumetto, L., Russo, G., & Barbato, F. (2016). Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption. Intern

The relationships between data of passage through Caco-2 cultured cell lines (log Pₐₚₚ), taken from the literature, for 38 structurally unrelated compounds and both n-octanol lipophilicity parameters (log Pᴺ and log D⁷.⁴) and phospholipid affinity in... Read More about Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption.