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Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption

Grumetto, Lucia; Russo, Giacomo; Barbato, Francesco

Authors

Lucia Grumetto

Francesco Barbato



Abstract

The relationships between data of passage through Caco-2 cultured cell lines (log P???), taken from the literature, for 38 structurally unrelated compounds and both n-octanol lipophilicity parameters (log P? and log D?.?) and phospholipid affinity indexes were investigated. Phospholipid affinity (log

Citation

Grumetto, L., Russo, G., & Barbato, F. (2016). Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption. International Journal of Pharmaceutics, 500(1-2), 275-290. https://doi.org/10.1016/j.ijpharm.2016.01.019

Journal Article Type Article
Acceptance Date Jan 9, 2016
Online Publication Date Jan 15, 2016
Publication Date 2016-03
Deposit Date Mar 31, 2020
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 500
Issue 1-2
Pages 275-290
DOI https://doi.org/10.1016/j.ijpharm.2016.01.019
Keywords IAM-HPLC; Lipophilicity; Caco-2; MDCK; Intestinal absorption; Oral bioavailability; Transcellular passage
Public URL http://researchrepository.napier.ac.uk/Output/2649513