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All Outputs (12677)

The Integration of Design and Manufacture ‐A Quantum Leap (1993)
Journal Article
Hunt, I., Roberts, S., & Jones, R. (1993). The Integration of Design and Manufacture ‐A Quantum Leap. Integrated Manufacturing Systems, 4(2), 15-19. https://doi.org/10.1108/09576069310037464

New product “time to market” in the information technology (IT) industry is increasingly critical to a company′s competitiveness. Early product release into the marketplace will ensure higher profit margins, quicker returns on investment and therefo... Read More about The Integration of Design and Manufacture ‐A Quantum Leap.

Direct sequencing of lambda DNA from crude lysates using an improved linear amplification technique (1993)
Journal Article
Lasham, A., & Darlison, M. G. (1993). Direct sequencing of lambda DNA from crude lysates using an improved linear amplification technique. Molecular and Cellular Probes, 7(1), 67-73. doi:10.1006/mcpr.1993.1009

We described an improved method for directly sequencing lambda (λ) DNA that has been isolated from either crude cleared lysates or plate lysates. This protocol does not require that the DNA be obtained from bacteriophage particles that have been puri... Read More about Direct sequencing of lambda DNA from crude lysates using an improved linear amplification technique.

A co-operative computer based on the principles of human co-operation (1993)
Journal Article
Clarke, A. A., & Smyth, M. (1993). A co-operative computer based on the principles of human co-operation. International journal of man-machine studies, 38(1), 3-22. https://doi.org/10.1006/imms.1993.1002

Co-operation is presented as a technique for radically improving human-computer interaction with complex knowledge bases during problem-identifying and problem-solving tasks. A study of human-human co-operation literature indicated the importance of... Read More about A co-operative computer based on the principles of human co-operation.

Architectures for persistence (1993)
Journal Article
Russell, G., & Cockshott, W. P. (1993). Architectures for persistence. Microprocessors and Microsystems, 17(3), 117-130. https://doi.org/10.1016/0141-9331%2893%2990042-6

Persistent object oriented architectures have been researched for many years, deriving initially from the Manchester University Atlas machine. In reality, however, few actual implementations of persistent architectures exist. In the first half of thi... Read More about Architectures for persistence.

Government Financial Assistance and Manufacturing Investment in Northern Ireland (1993)
Journal Article
Sheehan, M. (1993). Government Financial Assistance and Manufacturing Investment in Northern Ireland. Regional Studies, 27(6), 527-540. https://doi.org/10.1080/00343409312331347745

This paper analyses the influence of government grants on the investment decision making process in the Northern Ireland manufacturing sector. The paper is based on detailed interviews with Northern Ireland manufacturing firms and focuses on two time... Read More about Government Financial Assistance and Manufacturing Investment in Northern Ireland.

Molecular Characterisation and Functional Expression of Molluscan Ion-Channel Receptors That Can Be Activated By Either γ-Aminobutyric Acid or L-Glutamate (1993)
Journal Article
Darlison, M. G., Bermudez, I., Van Minnen, J., Zimmermann, C., Amar, M., Dautzenberg, F. M., Kim, H., Stühmer, T., & Harvey, R. J. (1993). Molecular Characterisation and Functional Expression of Molluscan Ion-Channel Receptors That Can Be Activated By Either γ-Aminobutyric Acid or L-Glutamate. Netherlands Journal of Zoology, 44(3), 473-485. https://doi.org/10.1163/156854293x00557

Ligand-gated ion channels (also called ionotropic receptors) are a class of receptors which possess an intrinsic ion pore, selective for either cations or anions, that can be opened by the binding of an appropriate neurotransmitter. Ionotropic recept... Read More about Molecular Characterisation and Functional Expression of Molluscan Ion-Channel Receptors That Can Be Activated By Either γ-Aminobutyric Acid or L-Glutamate.

Local authorities and economic development in Scotland (1992)
Journal Article
McQuaid, R. W. (1992). Local authorities and economic development in Scotland. Local work : CLES bulletin, 1-7

The recently published Consultation Paper on the reform of local government in Scotland presents options which will have profound effects upon economic development activities of Scottish local authorities. In order to promote an informed debate on th... Read More about Local authorities and economic development in Scotland.

Stomatococcus mucilaginosus: an emerging pathogen in neutropenic patients. (1992)
Journal Article
McWhinney, P. H. M., Kibbler, C. C., Gillespie, S. H., Patel, S., Morrison, D., Hoffbrand, A. V. & Prentice, H. G. (1991). Stomatococcus mucilaginosus: an emerging pathogen in neutropenic patients. Clinical Infectious Diseases. 14. . 641-646. . ISSN 1058-4838.

Stomatococcus mucilaginosus was isolated from eight neutropenic patients during nine febrile episodes over a 13-month period. Five of these isolates were from definite infections, including one case of fatal meningitis. This slime-producing, catalase... Read More about Stomatococcus mucilaginosus: an emerging pathogen in neutropenic patients..

Problems of drug abuse, HIV and AIDS: the burden of care in one general practice. (1992)
Journal Article
Ronald, P. J., Witcomb, J. C., Robertson, J. R., Roberts, J. J., Shishodia, P. C. & Whittaker, A. (1991). Problems of drug abuse, HIV and AIDS: the burden of care in one general practice. British Journal of General Practice. 42. . 232-235. . ISSN 0960-1643.

Responsibility for many of the problems of intravenous drug abuse and human immunodeficiency virus (HIV) infection lies with community care agencies, such as general practitioners, community psychiatric and district nurses and drug agencies. It is in... Read More about Problems of drug abuse, HIV and AIDS: the burden of care in one general practice..

Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies (1992)
Journal Article
Darlison, M. G. (1992). Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies. Trends in Neurosciences, 15(12), 469-474. https://doi.org/10.1016/0166-2236%2892%2990091-l

Determination of the sequences of invertebrate γ-aminobutyric acid (GABA)-gated and glutamate-gated receptor/ion channels, through the application of recombinant {DNA} methods, is not just an academic exercise to effect evolutionary comparisons with... Read More about Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies.

Making Sense of Pulse Oximetry (1992)
Journal Article
Coull, A. F. (1992). Making Sense of Pulse Oximetry. Nursing Times, 88(32),

No abstract available.

Making Sense of Surgical Flaps (1992)
Journal Article
Coull, A. F. (1992). Making Sense of Surgical Flaps. Nursing Times, 88(1),

No abstract available.

Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis (1992)
Journal Article
Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., …Darlison, M. G. (1992). Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8

The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investig... Read More about Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis.

GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis (1992)
Journal Article
Walsh, C., Hicks, A. A., Sham, P., Castle, D., Hunt, N., Clements, A., Sander, T., Murray, R., Darlison, M. G., & Gill, M. (1992). GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis. Psychiatric Genetics, 2(4), 239-248. https://doi.org/10.1097/00041444-199210000-00002

Polymorphic DNA segments can be used as genetic markers to test for allelic association between a disease and a candidate gene locus. Here we report the results of a study of 60 unrelated bipolar patients in which we sought for evidence of associatio... Read More about GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis.

Physiotherapy Management of Chronic Low Back Pain (1992)
Journal Article
Frost, H., & Moffett, J. K. (1992). Physiotherapy Management of Chronic Low Back Pain. Physiotherapy, 78(10), 751-754. https://doi.org/10.1016/s0031-9406%2810%2961638-0

Disability reported as a result of low back pain (LBP) has increased dramatically over the last 20 years. This paper reviews some of the scientific evidence currently available for the treatment of patients with LBP. The advantages of a more active a... Read More about Physiotherapy Management of Chronic Low Back Pain.

Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum (1992)
Journal Article
Austin, M., Dougall, N., Ross, M., Murray, C., O'Carroll, R. E., Moffoot, A., …Goodwin, G. M. (1992). Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders. 26. (1). 31-43. doi:10.1016/0165-0327(92)90032-2. ISSN 0165-0327.

Forty patients with a major depressive episode were investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, an intravenous ligand taken into brain in proportion to regional cerebral blood flow, thereby pro... Read More about Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum.

Semantic integrity for persistent objects (1992)
Journal Article
Barclay, P. J., & Kennedy, J. (1992). Semantic integrity for persistent objects. Information and Software Technology, 34(8), 533-541. https://doi.org/10.1016/0950-5849%2892%2990147-H

Modelling constructs for specifying semantic integrity are reviewed, and their implicit execution semantics discussed. An integrity maintenance model based on these constructs is presented. An implementation of this model in a persistent programming... Read More about Semantic integrity for persistent objects.