C. Walsh
GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis
Walsh, C.; Hicks, A. A.; Sham, P.; Castle, D.; Hunt, N.; Clements, A.; Sander, T.; Murray, R.; Darlison, M. G.; Gill, M.
Authors
A. A. Hicks
P. Sham
D. Castle
N. Hunt
A. Clements
T. Sander
R. Murray
M. G. Darlison
M. Gill
Abstract
Polymorphic DNA segments can be used as genetic markers to test for allelic association between a disease and a candidate gene locus. Here we report the results of a study of 60 unrelated bipolar patients in which we sought for evidence of association between bipolar affective disorder and alleles at two candidate genes (GABRA1 and GABRA3) involved in GABAergic neurotransmission. The data obtained were analysed in a number of ways. None of these produced conclusive evidence for association, although allele A6 at the GABRA1 locus was significant (p = 0.025) before correcting for multiple testing.
Citation
Walsh, C., Hicks, A. A., Sham, P., Castle, D., Hunt, N., Clements, A., Sander, T., Murray, R., Darlison, M. G., & Gill, M. (1992). GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis. Psychiatric Genetics, 2(4), 239-248. https://doi.org/10.1097/00041444-199210000-00002
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 1, 1992 |
Publication Date | 1992-10 |
Deposit Date | Aug 5, 2016 |
Journal | Psychiatric Genetics |
Print ISSN | 0955-8829 |
Electronic ISSN | 1473-5873 |
Publisher | Lippincott, Williams & Wilkins |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 4 |
Pages | 239-248 |
DOI | https://doi.org/10.1097/00041444-199210000-00002 |
Keywords | Genetics(clinical); Genetics; Biological Psychiatry; Psychiatry and Mental health |
Public URL | http://researchrepository.napier.ac.uk/Output/328008 |
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