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Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis

Johnson, Keith J.; Sander, Thomas; Hicks, Andrew A.; van Marle, Andr�; Janz, Dieter; Mullan, Michael J.; Riley, Brien P.; Darlison, Mark G.

Authors

Keith J. Johnson

Thomas Sander

Andrew A. Hicks

Andr� van Marle

Dieter Janz

Michael J. Mullan

Brien P. Riley

Mark G. Darlison



Abstract

The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investigation as candidate loci for a number of neurological and psychiatric disorders. We report here a highly polymorphic (dC-dA)n repeat within the human α1-subunit gene (GABRA1). Typing of this marker in the Centre d'Etude du Polymorphisme Humain (CEPH) panel of families confirms the previous assignment of the GABRA1 locus to the distal portion of chromosome 5q by demonstrating linkage to the markers CRI-L45 (D5S61) (Zmax = 11.00, θmax = 0.15), CRI-V1022 (D5S54) (Zmax = 7.25, θmax = 0.20), and CRI-P148 (D5S72) (Zmax = 5.71, θmax = 0.24).

Citation

Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., …Darlison, M. G. (1992). Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8

Journal Article Type Article
Acceptance Date Nov 1, 1992
Publication Date 1992-11
Deposit Date Aug 5, 2016
Journal Genomics
Print ISSN 0888-7543
Electronic ISSN 0888-7543
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 14
Issue 3
Pages 745-748
DOI https://doi.org/10.1016/s0888-7543%2805%2980178-8
Keywords Genetics
Public URL http://researchrepository.napier.ac.uk/Output/328038






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