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The Isolation of Genomic DNA from Invertebrates (1992)
Book Chapter
Vreugdenhil, E., & Darlison, M. G. (1992). The Isolation of Genomic DNA from Invertebrates. In A. Longstaff, & P. Revest (Eds.), Protocols in Molecular Neurobiology, 15-24. Springer Verlag. https://doi.org/10.1385/0-89603-199-3%3A15

Generally, genomic DNA is used either for the construction of genomic libraries or for Southern blot analysis. For several reasons, it is frequently preferable in the field of invertebrate neurobiology to screen, at least initially, genomic rather th... Read More about The Isolation of Genomic DNA from Invertebrates.

Making Sense of Pulse Oximetry (1992)
Journal Article
Coull, A. F. (1992). Making Sense of Pulse Oximetry. Nursing Times, 88(32),

No abstract available.

Making Sense of Surgical Flaps (1992)
Journal Article
Coull, A. F. (1992). Making Sense of Surgical Flaps. Nursing Times, 88(1),

No abstract available.

Control of a large massively parallel database machine using SQL catalogue extensions, and a DSDL in preference to an operating system (1992)
Presentation / Conference Contribution
Unwalla, M., & Kerridge, J. (1992, July). Control of a large massively parallel database machine using SQL catalogue extensions, and a DSDL in preference to an operating system. Presented at Advanced Database Systems: 10th British National Conference on Databases, BNCOD 10, Aberdeen, Scotland

The IDIOMS parallel database machine supports large applications where integrated OLTP and MIS is required. It can be considered a relational engine, and SQL is used as the MIS query language. We make some comparisons between IDIOMS and other databas... Read More about Control of a large massively parallel database machine using SQL catalogue extensions, and a DSDL in preference to an operating system.

Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis (1992)
Journal Article
Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., …Darlison, M. G. (1992). Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8

The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investig... Read More about Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis.

GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis (1992)
Journal Article
Walsh, C., Hicks, A. A., Sham, P., Castle, D., Hunt, N., Clements, A., Sander, T., Murray, R., Darlison, M. G., & Gill, M. (1992). GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis. Psychiatric Genetics, 2(4), 239-248. https://doi.org/10.1097/00041444-199210000-00002

Polymorphic DNA segments can be used as genetic markers to test for allelic association between a disease and a candidate gene locus. Here we report the results of a study of 60 unrelated bipolar patients in which we sought for evidence of associatio... Read More about GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis.

Physiotherapy Management of Chronic Low Back Pain (1992)
Journal Article
Frost, H., & Moffett, J. K. (1992). Physiotherapy Management of Chronic Low Back Pain. Physiotherapy, 78(10), 751-754. https://doi.org/10.1016/s0031-9406%2810%2961638-0

Disability reported as a result of low back pain (LBP) has increased dramatically over the last 20 years. This paper reviews some of the scientific evidence currently available for the treatment of patients with LBP. The advantages of a more active a... Read More about Physiotherapy Management of Chronic Low Back Pain.

Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum (1992)
Journal Article
Austin, M., Dougall, N., Ross, M., Murray, C., O'Carroll, R. E., Moffoot, A., …Goodwin, G. M. (1992). Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders. 26. (1). 31-43. doi:10.1016/0165-0327(92)90032-2. ISSN 0165-0327.

Forty patients with a major depressive episode were investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, an intravenous ligand taken into brain in proportion to regional cerebral blood flow, thereby pro... Read More about Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum.

Lens System (1992)
Patent
Binnie, D. (1992). Lens System. WO 1992015036 A1. GB

The present invention relates to a lens system (2) suitable for substantially direct interfacing with the image sensing surface (3) of a solid state image capture device (4). The lens system (2) comprises a lens (8) and a spacer (a) in substantially... Read More about Lens System.

Semantic integrity for persistent objects (1992)
Journal Article
Barclay, P. J., & Kennedy, J. (1992). Semantic integrity for persistent objects. Information and Software Technology, 34(8), 533-541. https://doi.org/10.1016/0950-5849%2892%2990147-H

Modelling constructs for specifying semantic integrity are reviewed, and their implicit execution semantics discussed. An integrity maintenance model based on these constructs is presented. An implementation of this model in a persistent programming... Read More about Semantic integrity for persistent objects.

Streptococci and Related Organism. (1992)
Book Chapter
Colman, G., Efstratiou, A., & Morrison, D. (1992). Streptococci and Related Organism. In R. G. Board, D. Jones, & F. A. Skinner (Eds.), Identification Methods in Applied and Environmental MicrobiologyWiley-Blackwell

QALYs in mental health: a case study (1992)
Journal Article
Wilkinson, G., Williams, B., Krekorian, H., McLees, S., & Falloon, I. (1992). QALYs in mental health: a case study. Psychological Medicine, 22(3), 725. https://doi.org/10.1017/S0033291700038162

The applicability of the Charing Cross health indicator (CH-X) to the field of mental health was investigated in a community setting using descriptive statistics and principal components analysis. The CH-X is based on assessments of (i) distress and... Read More about QALYs in mental health: a case study.

Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor (1992)
Journal Article
Zaman, S. H., Harvey, R. J., Barnard, E. A., & Darlison, M. G. (1992). Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor. FEBS Letters, 307(3), 351-354. https://doi.org/10.1016/0014-5793%2892%2980711-o

We have previously reported [(1991) EMBO J. 10, 3239–3245] the sequence of an invertebrate γ‐aminobutyric acid (GABA) type A (GABAA) receptor polypeptide which forms homo‐oligomeric GABA‐gated, bicuculline‐sensitive, chloride‐ion channels upon hetero... Read More about Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor.

Assembly of functional GABAA receptors in insect cells using baculovirus expression vectors (1992)
Journal Article
Atkinson, A. E., Bermudez, I., Darlison, M. G., Barnard, E. A., Earley, F. G. P., Possee, R. D., Beadle, D. J., & King, L. A. (1992). Assembly of functional GABAA receptors in insect cells using baculovirus expression vectors. NeuroReport, 3(7), 597-600. https://doi.org/10.1097/00001756-199207000-00013

We have constructed recombinant baculoviruses containing cDNAs encoding either the [alpha]1- or the [beta]1-subunit of the bovine GABAA receptor. In Spodoptera frugiperda (IPLB-Sf-21) cells infected with recombinant virus expressing either the [alpha... Read More about Assembly of functional GABAA receptors in insect cells using baculovirus expression vectors.

Influence of the soft state on the performance of development finance institutions (1992)
Thesis
Maynard, J. E. Influence of the soft state on the performance of development finance institutions. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/4488

Development finance institutions put money into capital projects where conventional intermediaries are reluctant to get involved, and/or where there is a political preference for this channel of investment. In the last few decades D.F.l.s have especi... Read More about Influence of the soft state on the performance of development finance institutions.

Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel (1992)
Journal Article
Traupe, H., Ouweland, A. M. V. D., Oost, B. A. V., Vogel, W., Vetter, U., Warren, S. T., Rocchi, M., Darlison, M. G., & Ropers, H. (1992). Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics, 13(2), 481-483. https://doi.org/10.1016/0888-7543%2892%2990279-2

Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The human gene for biglycan (BGN) has previously been mapped by in situ hybridizat... Read More about Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel.

Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid (1992)
Journal Article
Zaman, S. H., Shingai, R., Harvey, R. J., Darlison, M. G., & Barnard, E. A. (1992). Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid. European journal of pharmacology. Molecular pharmacology section, 225(4), 321-330. https://doi.org/10.1016/0922-4106%2892%2990106-6

When vertebrate brain poly(A)+ RNA is expressed in Xenopus oocytes the response of the GABA receptors formed is found to be inhibited allosterically by a neurosteroid, pregnenolone sulphate (PS). This negative modulation was reproduced after expressi... Read More about Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.