Skip to main content

Research Repository

Advanced Search

All Outputs (80)

Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain. (2014)
Journal Article
Sa, R. C. C., Cunningham, A. A., Dagleish, M. P., Wheelhouse, N., Pocknell, A., Borel, N., …Lawson, B. (2014). Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain. European journal of wildlife research, 60(2), 395-398. https://doi.org/10.1007/s10344-013-0792-x

The ring-necked parakeet (RNP), Psittacula krameri, is an invasive species in Great Britain (GB) which is undergoing rapid population expansion in the wild. Although it has been suggested that RNPs could be a potential source of infectious disease, l... Read More about Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain..

Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes (2014)
Journal Article
Sait, M., Livingstone, M., Clark, E. M., Wheelhouse, N., Spalding, L., Markey, B., …Longbottom, D. (2014). Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes. BMC Genomics, 15, 23.

BACKGROUND: Chlamydia pecorum is the causative agent of a number of acute diseases, but most often causes persistent, subclinical infection in ruminants, swine and birds. In this study, the genome sequences of three C. pecorum strains isolated from t... Read More about Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes.

Risk factors associated with Lawsonia intracellularis in English pig farms (2013)
Journal Article
Bae, J. K., Wieland, B., Sait, M., Longbottom, D., Smith, D. G. E., Alarcon, P., & Wheelhouse, N. (2013). Risk factors associated with Lawsonia intracellularis in English pig farms. Veterinary Journal, 197(3), 707-711. https://doi.org/10.1016/j.tvjl.2013.

Porcine proliferative enteropathy (PPE) caused by the bacterium Lawsonia intracellularis causes considerable economic loss to the pig industry. The objective of this study was to evaluate the seroprevalence of L. intracellularis exposure in different... Read More about Risk factors associated with Lawsonia intracellularis in English pig farms.

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep (2013)
Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., …Buxton, D. (2013). Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), Article e57950. https://doi.org/10.1371/journal.pone.0057950

BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is ab... Read More about Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep.

Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle (2012)
Journal Article
Longbottom, D., Wheelhouse, N., Sait, M., Wilson, K., Aitchison, K., McLean, K., & Smith, D. G. E. (2012). Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle. Veterinary Microbiology, 160(3-4), 525-5

It has been suggested that polymorphic membrane proteins (Pmps) belonging to the Type V autotransporter protein family play an important role in the pathogenesis of Chlamydia abortus (C. abortus; formerly Chlamydophila abortus) infection. In a previo... Read More about Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle.

Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle (2012)
Journal Article
Wheelhouse, N. M., Sait, M., Aitchison, K., Livingstone, M., Wright, F., McLean, K., …Longbottom, D. (2012). Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle. PLOS ONE, 7, Article e49190. https://doi.org/10.1371/journal.pone.0049190

BACKGROUND: Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membrane proteins (Pmps). While the total number of pmp genes varies between Chlamydia species, all encode a single pmpD gene. In both Chlamydia tracho... Read More about Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle.

Evaluation of the impact and control of enzootic abortion of ewes (2012)
Journal Article
Longbottom, D., Entrican, G., Wheelhouse, N., Brough, H., & Milne, C. (2013). Evaluation of the impact and control of enzootic abortion of ewes. Veterinary Journal, 195(2), 257-259. https://doi.org/10.1016/j.tvjl.2012.06.018

Despite the availability of effective management and treatment strategies, Chlamydia abortus remains the single most frequently diagnosed cause of infectious ovine abortion (enzootic abortion of ewes, EAE) in the UK and one of the most significant ca... Read More about Evaluation of the impact and control of enzootic abortion of ewes.

Involvement of Parachlamydia in bovine abortions in Scotland (2012)
Journal Article
Howie, F., Gidlow, J., Greub, G., Wheelhouse, N., Dagleish, M., & Longbottom, D. (2012). Involvement of Parachlamydia in bovine abortions in Scotland. Veterinary Journal, 193(2), 586-588. https://doi.org/10.1016/j.tvjl.2012.01.008

Bovine abortion represents a major animal welfare issue and a cause of substantial economic loss yet the rate of successful diagnosis remains low. Chlamydia-related organisms including Parachlamydia have recently emerged as putative cattle abortifaci... Read More about Involvement of Parachlamydia in bovine abortions in Scotland.

New challenges for vaccination to prevent chlamydial abortion in sheep (2011)
Journal Article
Entrican, G., Wheelhouse, N., Wattegedera, S. R., & Longbottom, D. (2012). New challenges for vaccination to prevent chlamydial abortion in sheep. Comparative Immunology, Microbiology and Infectious Diseases, 35(3), 271-276. https://doi.org/10.1016/j.cimi

Ovine enzootic abortion (OEA) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. OEA remains a common cause of infectious abortion in many sheep-rearing countries despite the existence of commercially available vaccine... Read More about New challenges for vaccination to prevent chlamydial abortion in sheep.

Endemic and emerging chlamydial infections of animals and their zoonotic implications (2011)
Journal Article
Wheelhouse, N., & Longbottom, D. (2011). Endemic and emerging chlamydial infections of animals and their zoonotic implications. Transboundary and Emerging Diseases, 59(4), 283-291. https://doi.org/10.1111/j.1865-1682.2011.01274.x

The Chlamydiae are a diverse group of obligate intracellular Gram-negative bacteria that are known to infect a wide variety of host species and are responsible for a wide range of diseases in animals and man. Many of these organisms have been extensi... Read More about Endemic and emerging chlamydial infections of animals and their zoonotic implications.

Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae (2011)
Journal Article
Sait, M., Livingstone, M., Graham, R., Inglis, N. F., Wheelhouse, N., & Longbottom, D. (2011). Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae. Journal of General Virology, 92(7), 1733-1737. https://doi.org/10.1099/vir.0.031583-0

Members of the family Microviridae have been identified in a number of chlamydial species infecting humans (phage CPAR39 in Chlamydophila pneumoniae), other mammals (phiCPG1 in Chlamydophila caviae, Chp2 in Chlamydophila abortus and Chp3 in Chlamydop... Read More about Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae.

Genome sequence of the Chlamydophila abortus variant strain LLG (2011)
Journal Article
Sait, M., Clark, E. M., Wheelhouse, N., Livingstone, M., Spalding, L., Siarkou, V. I., …Longbottom, D. (2011). Genome sequence of the Chlamydophila abortus variant strain LLG. Journal of Bacteriology, 193(16), 4276-4277. https://doi.org/10.1128/JB.05290-11

Chlamydophila abortus is a common cause of ruminant abortion. Here we report the genome sequence of strain LLG, which differs genotypically and phenotypically from the wild-type strain S26/3. Genome sequencing revealed differences between LLG and S26... Read More about Genome sequence of the Chlamydophila abortus variant strain LLG.

Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks (2011)
Journal Article
Lowrie, A. G., Dickinson, P., Wheelhouse, N., Stewart, G. D., Ross, A. J., Forster, T., & Ross, J. A. (2011). Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks. International Journal of Oncology, 39(3), 709-18. https://doi.org/10.3892/ijo.2011.1064

Dermcidin is a candidate oncogene capable of increasing the number of cultured neuronal, breast cancer and prostate cancer cells and improving the survival of hepatic cells. The dermcidin gene encodes the proteolysis-inducing factor core pepti... Read More about Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks.

Molecular detection of Chlamydia-like organisms in cattle drinking water (2011)
Journal Article
Wheelhouse, N., Saita, M., Gidlow, J., Deuchande, R., Borel, N., Baily, J., …Longbottom, D. (2011). Molecular detection of Chlamydia-like organisms in cattle drinking water. Veterinary Microbiology, 152(1-2), 196-199. https://doi.org/10.1016/j.vetmic.20

A substantial proportion of the causes of infectious bovine abortion remain largely undiagnosed, potentially due to the presence of previously unrecognised infectious agents. Recently, several reports have demonstrated the presence of Parachlamydia s... Read More about Molecular detection of Chlamydia-like organisms in cattle drinking water.

Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes (2011)
Journal Article
Saita, M., Clarka, E. M., Wheelhouse, N., Spalding, L., Livingstone, M., Sachse, K., …Longbottom, D. (2011). Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes. Veterinary Mi

This study used PCR-RFLP to investigate the genetic variability of pmp-encoding genes from fifty-two Chlamydophila abortus (C. abortus) strains originating from abortion cases from various geographical regions and host species. Six primer pairs were... Read More about Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes.

Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy (2010)
Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K., Horner, P. J., McClure, M. O., Abrahams, V. M., …Horne, A. W. (2011). Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ect

Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. Fallopian tube (FT) from women with EP exhibit altered expression of prokine... Read More about Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy.

Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression (2010)
Journal Article
Fitch, P., Wheelhouse, N., Bowles, P., Paterson, M., Longbottom, D., Entrican, G., & Howie, S. (2010). Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression. Clinical and Experimental Immunology, 162(2), 372-378. https://doi.org/10.1111/j.1365-2249.2010.04231.x

Infection with Chlamydia pneumoniae (Cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. We describe a C57/Bl6 murine model of Cp lung infection characterized by a... Read More about Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression.

Immunological paradigms and the pathogenesis of ovine chlamydial abortion (2010)
Journal Article
Entrican, G., Wattegedera, S., Wheelhouse, N., Allan, A., & Rocchi, M. (2010). Immunological paradigms and the pathogenesis of ovine chlamydial abortion. American Journal of Reproductive Immunology, 64(4), 287-294. https://doi.org/10.1111/j.1600-0897.2010.00907.x

Successful mammalian pregnancy involves complex immunological interactions between the mother and foetus that are not yet fully understood. A number of immunological paradigms have been established to explain the failure of the maternal immune system... Read More about Immunological paradigms and the pathogenesis of ovine chlamydial abortion.