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All Outputs (53)

Social cognition and paranoia in forensic inpatients with schizophrenia: A cross-sectional study (2016)
Journal Article
Bratton, H., O'Rourke, S., Tansey, L., & Hutton, P. (2016). Social cognition and paranoia in forensic inpatients with schizophrenia: A cross-sectional study. Schizophrenia Research, 184, 96-102. https://doi.org/10.1016/j.schres.2016.12.004

Background People diagnosed with schizophrenia have difficulties in emotion recognition and theory of mind, and these may contribute to paranoia. The aim of this study was to determine whether this relationship is evident in patients residing in a s... Read More about Social cognition and paranoia in forensic inpatients with schizophrenia: A cross-sectional study.

Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial (2016)
Journal Article
Pyle, M., Schwannauer, M., Norrie, J., Kingdon, D., Gumley, A., Turkington, D., Byrne, R., Syrett, S., MacLennan, G., Dudley, R., McLeod, H. J., Griffiths, H., Bowe, S., Barnes, T. R. E., French, P., Hutton, P., Davies, L., & Morrison, A. P. (2016). Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial. BMC Psychiatry, 16(280), https://doi.org/10.1186/s12888-016-0983-6

Background For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozap... Read More about Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial.

Shared treatment decision-making and empowerment-related outcomes in psychosis: systematic review and meta-analysis (2016)
Journal Article
Stovell, D., Morrison, A. P., Panayiotou, M., & Hutton, P. (2016). Shared treatment decision-making and empowerment-related outcomes in psychosis: systematic review and meta-analysis. British Journal of Psychiatry, 209(1), 23-28. https://doi.org/10.1192/bjp.bp.114.158931

BACKGROUND: In the UK almost 60% of people with a diagnosis of schizophrenia who use mental health services say they are not involved in decisions about their treatment. Guidelines and policy documents recommend that shared decision-making should be... Read More about Shared treatment decision-making and empowerment-related outcomes in psychosis: systematic review and meta-analysis.

Cognitive therapy for internalised stigma in people experiencing psychosis: A pilot randomised controlled trial (2016)
Journal Article
Morrison, A. P., Burke, E., Murphy, E., Pyle, M., Bowe, S., Varese, F., Dunn, G., Chapman, N., Hutton, P., Welford, M., & Wood, L. J. (2016). Cognitive therapy for internalised stigma in people experiencing psychosis: A pilot randomised controlled trial. Psychiatry Research, 240(30), 96-102. https://doi.org/10.1016/j.psychres.2016.04.024

We aimed to evaluate the feasibility of Cognitive Therapy (CT) as an intervention for internalised stigma in people with psychosis. We conducted a single-blind randomised controlled pilot trial comparing CT plus treatment as usual (TAU) with TAU only... Read More about Cognitive therapy for internalised stigma in people experiencing psychosis: A pilot randomised controlled trial.

Service users’ experiences of the treatment decision-making process in psychosis: A phenomenological analysis (2016)
Journal Article
Stovell, D., Wearden, A., Morrison, A. P., & Hutton, P. (2016). Service users’ experiences of the treatment decision-making process in psychosis: A phenomenological analysis. Psychosis, 8(4), 311-323. https://doi.org/10.1080/17522439.2016.1145730

Objectives: We aimed to explore the treatment decision-making experiences of individuals with psychosis, and their implications for increasing service users autonomy through clinical practice and research. Design: A qualitative design was used... Read More about Service users’ experiences of the treatment decision-making process in psychosis: A phenomenological analysis.

In reply to Adams and colleagues (2015)
Journal Article
Hutton, P., Taylor, P. J., & Morrison, A. P. (2015). In reply to Adams and colleagues. Psychosis, 7(4), 367-367. https://doi.org/10.1080/17522439.2015.1093017

Dear Editor We disagree with the Cochrane Schizophrenia Group’s (CSzG) self-assessment that the problems we identified (Hutton, Wood, Taylor, Irving & Morrison, 2014) in their reviews of popular antipsychotics for schizophrenia are not serious. We... Read More about In reply to Adams and colleagues.

Psychosis, delusions and the “jumping to conclusions” reasoning bias: a systematic review and meta-analysis (2015)
Journal Article
Taylor, P., Dudley, R., Wickham, S., & Hutton, P. (2015). Psychosis, delusions and the “jumping to conclusions” reasoning bias: a systematic review and meta-analysis. Schizophrenia Bulletin, 42(3), 652-665. https://doi.org/10.1093/schbul/sbv150

We did a systematic review and meta-analysis to investigate the magnitude and specificity of the “jumping to conclusions” (JTC) bias in psychosis and delusions. We examined the extent to which people with psychosis, and people with delusions specific... Read More about Psychosis, delusions and the “jumping to conclusions” reasoning bias: a systematic review and meta-analysis.

Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal (2015)
Journal Article
Hutton, P., Taylor, P. J., Mulligan, L., Tully, S., & Moncrieff, J. (2015). Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal. British Journal of Psychiatry, 206(5), 360-370. https://doi.org/10.1192/bjp.bp.114.154377

Background: Immediate-release (IR) quetiapine has been used to treat schizophrenia since 1997, although all the principal placebo-controlled trials have >50% missing outcome data. New studies with relatively lower rates of participant withdrawal hav... Read More about Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal.

Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire (2015)
Journal Article
Taylor, P. J., Pyle, M., Schwannauer, M., Hutton, P., & Morrison, A. P. (2015). Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire. British Journal of Clinical Psychology, 54(4), 361-377. https://doi.org/10.1111/bjc.12079

Objectives: Negative beliefs about psychosis and other mental health difficulties may contribute to depression and distress in individuals with these experiences. The Personal Beliefs about Experience Questionnaire (PBEQ) and Personal Beliefs about... Read More about Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire.

Are people at risk of psychosis also at risk of suicide and self-harm? A systematic review and meta-analysis (2014)
Journal Article
Taylor, P. J., Hutton, P., & Wood, L. (2015). Are people at risk of psychosis also at risk of suicide and self-harm? A systematic review and meta-analysis. Psychological Medicine, 45(5), 911-926. https://doi.org/10.1017/S0033291714002074

Suicide and self-harm are prevalent in individuals diagnosed with psychotic disorders. However, less is known about the level of self-injurious thinking and behaviour in those individuals deemed to be at ultra-high risk (UHR) of developing psychosis,... Read More about Are people at risk of psychosis also at risk of suicide and self-harm? A systematic review and meta-analysis.

Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis (2014)
Journal Article
Taylor, P. J., Perry, A., Hutton, P., Seddon, C., & Tan, R. (2015). Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis. Psychosis, 7(3), 276-278. https://doi.org/10.1080/17522439.2014.956785

In the interests of providing patient choice and developing more effective interventions forvpeople struggling with psychosis, it is important that alternative talking therapies arevexplored. Cognitive Analytic Therapy is an integrative therapy which... Read More about Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis.

Cognitive therapy for patients with schizophrenia–Authors' reply (2014)
Journal Article
Morrison, A. P., Dunn, G., Turkington, D., Pyle, M., & Hutton, P. (2014). Cognitive therapy for patients with schizophrenia–Authors' reply. Lancet, 384(9941), 401-402. https://doi.org/10.1016/S0140-6736%2814%2961275-7

Our trial1 was not designed to change clinical practice. It was a preliminary trial, which needs to be followed up by a larger, pragmatic multicentre study. It is important not to overinterpret our data, and we explicitly advised against discontinuat... Read More about Cognitive therapy for patients with schizophrenia–Authors' reply.

Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions (2014)
Journal Article
Taylor, P., Hutton, P., & Dudley, R. (2014). Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions. Systematic Reviews, 3(44), https://doi.org/10.1186/2046-4053-3-44

Background The tendency to form conclusions based on limited evidence is known as the ‘jumping to conclusions’ (JTC) bias, and has been a much studied phenomena in individuals with psychosis. Previous reviews have supported the hypothesis that a JTC... Read More about Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions.

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial (2014)
Journal Article
Morrison, A. P., Turkington, D., Pyle, M., Spencer, H., Brabban, A., Dunn, G., Christodoulides, T., Dudley, R., Chapman, N., Callcott, P., Grace, T., Lumley, V., Drage, L., Tully, S., Irving, K., Cummings, A., Byrne, R., Davies, L. M., & Hutton, P. (2014). Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial. Lancet, 383(9926), 1395-1403. https://doi.org/10.1016/s0140-6736%2813%2962246-1

BACKGROUND: Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment. We aimed to establish whether cognitive therapy was effective in reducing psychi... Read More about Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.

Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis (2013)
Journal Article
Hutton, P., Wood, L., Taylor, P. J., Irving, K., & Morrison, A. P. (2014). Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis. Psychosis, 6(3), 220-230. https://doi.org/10.1080/17522439.2013.825005

Background: Cognitive behavioural therapy (CBT) is a recommended treatment for people with psychosis, with meta - analyses showing important benefits when compared to treatment as usual (TAU). However, there has been growing debate as to whether CBT... Read More about Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis.

Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis (2013)
Journal Article
Hutton, P. (2013). Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis. Psychology and Psychotherapy: Theory, Research and Practice, 86(2), 139-145. doi:10.1111/papt.12009

Newton-Howes and Wood (published online, this journal, 8 Dec 2011) report the results of their systematic review and meta-analysis of clinical trials of cognitive-behavioural therapy (CBT) for schizophrenia. They ran a random effects analysis of endp... Read More about Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis.

Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis (2013)
Journal Article
Taylor, P. J., Hutton, P., & Taylor, P. J. (2014). Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis. Psychological Medicine, 44(3), 449-468. https://doi.org/10.1017/s0033291713000354

Background. Clinical equipoise regarding preventative treatments for psychosis has encouraged the development and evaluation of psychosocial treatments, such as cognitive behavioural therapy (CBT). Method. A systematic review and meta-analysis w... Read More about Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis.

Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial (2013)
Journal Article
Morrison, A. P., Wardle, M., Hutton, P., Davies, L., Dunn, G., Brabban, A., …Turkington, D. (2013). Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial. Psychosis, 5(1), 82-92. https://doi.org/10.1080/17522439.2012.756539

Aims: Recent evidence regarding over-estimation of the efficacy of antipsychotics and under-estimation of their toxicity, as well as emerging data regarding alternative treatment options, suggest it may be time to introduce patient choice. However,... Read More about Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial.

Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study (2013)
Journal Article
Hutton, P., Morrison, A. P., Wardle, M., & Wells, A. (2014). Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study. Behavioural and Cognitive Psychotherapy, 42(2), 166-185. https://doi.org/10.1017/S1352465812001026

Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitiv... Read More about Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study.