All Outputs (5)

CD3 limits the efficacy of TCR gene therapy in vivo (2011)
Journal Article
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. Blood, 118(13), 3528-3537. https://doi.org/10.1182/blood-2011-04-346338

The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR
/ heterodimer. We tested whether endogenous CD3 chains are rate-limiting for TCR expression and antigen-specific T-cell fu... Read More about CD3 limits the efficacy of TCR gene therapy in vivo.

Therapeutic potential of Tregs to treat rheumatoid arthritis (2011)
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there ar... Read More about Therapeutic potential of Tregs to treat rheumatoid arthritis.

Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies (2011)
Journal Article
Kinloch, A. J., Ng, K., & Wright, G. P. (2011). Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. Recent patents on inflammation & allergy drug discovery, 5(2), 108-127. https://doi.org/10.2174/187221311795399246

Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct autoimmune disease very recently. The lack of understanding of the specific autoimmune system/... Read More about Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies.

Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity (2011)
Journal Article
Wright, G. P., Ehrenstein, M. R., & Stauss, H. J. (2011). Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity. Expert Review of Clinical Immunology, 7(2), 213-225. https://doi.org/10.1586/eci.10.96

Tregs have shown considerable potential in treating preclinical models of autoimmunity. These studies have highlighted the importance of Treg antigen (Ag) specificity. Translation of these promising results to the clinic will require a robust method... Read More about Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity.

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells (2011)
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8)

The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in the removal of apoptotic cells, we investigated whether the immune modulator... Read More about Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.