Bendigoles A~C, New Steroids from Gordonia australis Acta 2299

Schneider, Kathrin; Graf, Ellen; Irran, Elisabeth; Nicholson, Graeme; Stainsby, Fiona M; Goodfellow, Michael; Borden, Steffen A; Keller, Simone; S�ssmuth, Roderich D; Fiedler, Hans-Peter

Abstract

Bendigoles A~C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A~C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.

Citation

Schneider, K., Graf, E., Irran, E., Nicholson, G., Stainsby, F. M., Goodfellow, M., …Fiedler, H. (2008). Bendigoles A~C, New Steroids from Gordonia australis Acta 2299. Journal of Antibiotics, 61(6), 356-364. https://doi.org/10.1038/ja.2008.50

• Journal Article Type: Article
• Acceptance Date: May 28, 2008
• Publication Date: 2008-06
• Deposit Date: Aug 5, 2016
• Journal: The Journal of Antibiotics
• Electronic ISSN: 0021-8820
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 61
• Issue: 6
• Pages: 356-364
• DOI: https://doi.org/10.1038/ja.2008.50
• Keywords: bendigole A, bendigole B, bendigole C, Gordonia, steroids, fermentation, isolation, structure elucidation
• Public URL: http://researchrepository.napier.ac.uk/Output/327713