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Bendigoles A~C, New Steroids from Gordonia australis Acta 2299

Schneider, Kathrin; Graf, Ellen; Irran, Elisabeth; Nicholson, Graeme; Stainsby, Fiona M; Goodfellow, Michael; Borden, Steffen A; Keller, Simone; S�ssmuth, Roderich D; Fiedler, Hans-Peter


Kathrin Schneider

Ellen Graf

Elisabeth Irran

Graeme Nicholson

Michael Goodfellow

Steffen A Borden

Simone Keller

Roderich D S�ssmuth

Hans-Peter Fiedler


Bendigoles A~C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A~C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.


Schneider, K., Graf, E., Irran, E., Nicholson, G., Stainsby, F. M., Goodfellow, M., …Fiedler, H. (2008). Bendigoles A~C, New Steroids from Gordonia australis Acta 2299. Journal of Antibiotics, 61(6), 356-364.

Journal Article Type Article
Acceptance Date May 28, 2008
Publication Date 2008-06
Deposit Date Aug 5, 2016
Journal The Journal of Antibiotics
Electronic ISSN 0021-8820
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 61
Issue 6
Pages 356-364
Keywords bendigole A, bendigole B, bendigole C, Gordonia, steroids, fermentation, isolation, structure elucidation
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