Skip to main content

Research Repository

Advanced Search

Anticancer profile of newly synthesized BRAF inhibitors possess 5-(pyrimidin-4-yl)imidazo[2,1-b]thiazole scaffold

Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Oh, Chang-Hyun


Mohammed S. Abdel-Maksoud

Chang-Hyun Oh


In this work, a new series of imidazo[2,1-b]thiazole was designed and synthesized. The new compounds are having 3-fluorophenyl at position 6 of imidazo[2,1-b]thiazole and pyrimidine ring at position 5. The pyrimidine ring containing either amide or sulphonamide moiety attached to a linker (ethyl or propyl) at position 2 of the pyrimidine ring. The final compounds were selected by NCI for in vitro cytotoxicity screening. Most derivatives showed cytotoxic activity against colon cancer and melanoma cell lines. In addition, IC 50 s of the target compounds were determined over A375 and SK-MEL-28 cell lines using sorafenib as positive control. Compounds12b, 12c, 12e, 12f, 15a, 15d, 15f, 14g and 15h exhibited superior activity when compared to sorafenib. The most potent compounds were tested against wild type BRAF, v600e BRAF, and CRAF. Compound 15h exhibited a potential inhibitory effect against V600E BRAF (IC 50 = 9.3 nM).

Journal Article Type Article
Acceptance Date Mar 31, 2019
Online Publication Date Apr 2, 2019
Publication Date 2019-05
Deposit Date Dec 11, 2022
Journal Bioorganic & Medicinal Chemistry
Print ISSN 0968-0896
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 27
Issue 10
Pages 2041-2051
Keywords Imidazo[2,1-b]thiazole, Anticancer, Colon cancer, Melanoma, BAF inhibitors
Public URL