Impact of marathon running on cardiac structure and function in recreational runners

Whyte, Greg P; George, Keith; Shave, Robert; Dawsons, Ellen; Stephenson, Claire; Edwards, Ben; Gaze, David; Oxborough, David; Forster, Jan; Simpson, Richard J

Abstract

The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35±10 years; height, 1.74±0.08 m; body mass, 75.9±8.9 kg) were assessed pre- and immediately post-marathon. LV function was assessed using standard M-mode two-dimensional Doppler echocardiography and TDI (tissue-Doppler imaging) echocardiography. Serum was analysed for cTnT (cardiac troponin-T), TEAC (Trolox equivalent antioxidant capacity; a measure of total antioxidant capacity), MDA (malondealdehyde) and 4-HNE (4-hydroxynonenal). A strong relationship was observed between standard and TDI echocardiography for all functional measures. Diastolic function was altered post-marathon characterized by a reduction in E (peak early diastolic filling: 0.79±0.11 compared with 0.64±0.16 cm/s; P

Citation

Whyte, G. P., George, K., Shave, R., Dawsons, E., Stephenson, C., Edwards, B., Gaze, D., Oxborough, D., Forster, J., & Simpson, R. J. (2005). Impact of marathon running on cardiac structure and function in recreational runners. Clinical Science, 108(1), 73-80. https://doi.org/10.1042/CS20040186

• Journal Article Type: Article
• Acceptance Date: Sep 20, 2004
• Publication Date: 2005-01
• Deposit Date: Jun 20, 2008
• Print ISSN: 0143-5221
• Electronic ISSN: 1470-8736
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 108
• Issue: 1
• Pages: 73-80
• DOI: https://doi.org/10.1042/CS20040186
• Keywords: Cardiac troponin T; Echocardiography; Marathon; Tissue Doppler imaging; Reactive oxygen species; Left ventricular functioning; Oxidative stress
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/1637
• Publisher URL: http://www.clinsci.org/cs/108/0073/cs1080073.htm