Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run

Gomes, Elisa Couto; Stone, Vicki; Florida-James, Geraint

Abstract

To investigate the acute effect of a hot, humid and ozone-polluted (O3) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean V˙O2max = 64.4 mlO2 kg−1 min−1, SD = 4.4) took part in a time trial run in four different environmental conditions: 20°C + 50% relative humidity (rh) (Control); 20°C + 50% rh + 0.10 ppm O3 (Control + O3); 31°C + 70% rh (Heat); 31°C + 70% rh + 0.10 ppm O3 (Heat + O3). Blood samples and nasal lavage were collected post-exercise and analyzed for inflammatory, epithelial damage and oxidative stress markers. Data were analyzed using repeated measures ANOVA with Tukey’s post hoc test. A significant increase in CC16 concentration (P < 0.05) and GSH/protein concentration (P < 0.05) in the upper respiratory airways was observed following the 8 km run in the Heat + O3 trial compared with the control trial. There were no differences in the neutrophil counts between trials. No differences were observed for the other antioxidants analyzed. A hot, humid and ozone-polluted environment (0.1 ppm) elicits an early epithelial damage and antioxidant protection process in the upper respiratory airways of athletes immediately after performing 8 km time trial run.

Citation

Gomes, E. C., Stone, V., & Florida-James, G. (2011). Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run. European Journal of Applied Physiology, 111(9), 2089-2097. https://doi.org/10.1007/s00421-011-1839-x

• Journal Article Type: Article
• Online Publication Date: Jan 26, 2011
• Publication Date: 2011-09
• Deposit Date: Mar 13, 2014
• Print ISSN: 1439-6319
• Electronic ISSN: 1439-6327
• Publisher: BMC
• Peer Reviewed: Peer Reviewed
• Volume: 111
• Issue: 9
• Pages: 2089-2097
• DOI: https://doi.org/10.1007/s00421-011-1839-x
• Keywords: Public Health, Environmental and Occupational Health; Physiology (medical); Orthopedics and Sports Medicine; General Medicine
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/6631
• Publisher URL: http://dx.doi.org/10.1007/s00421-011-1839-x