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Outputs (16)

A role for the metalloprotease invadolysin in insulin signaling and adipogenesis (2016)
Journal Article
Chang, C.-W., Abhinav, K., Di Cara, F., Panagakou, I., Vass, S., & Heck, M. M. (2017). A role for the metalloprotease invadolysin in insulin signaling and adipogenesis. Biological Chemistry, 398(3), 373-393. https://doi.org/10.1515/hsz-2016-0226

Invadolysin is a novel metalloprotease conserved amongst metazoans that is essential for life in Drosophila. We previously showed that invadolysin was essential for the cell cycle and cell migration, linking to metabolism through a role in lipid stor... Read More about A role for the metalloprotease invadolysin in insulin signaling and adipogenesis.

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart (2015)
Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., Chapman, K. E., Mullins, J. J., Kenyon, C., Hadoke, P. W. F., & Denvir, M. A. (2015). Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025

Background

Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations of GC on adult heart structure, function and gene expression were assessed... Read More about Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart.

Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart (2015)
Presentation / Conference Contribution
Wilson, K., Baily, J., Tucker, C., Vass, S., Moran, C., Chapman, K., Mullins, J., Kenyon, C., Hadoke, P., & Denvir, M. Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart

Introduction Foetal over-exposure to glucocorticoids (GC) has been associated with cardiovascular disorder in later life however the impact of transient early life alterations in GC activity on the heart itself has not been widely studied. We explore... Read More about Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart.

Invadolysin acts genetically via the SAGA complex to modulate chromosome structure (2015)
Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., Abhinav, K., Panagakou, I., Vass, S., & Heck, M. M. S. (2015). Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211

Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosophila, with roles in cell division and cell migration. Mitotic chromosomes ar... Read More about Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.

Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture (2014)
Journal Article
Pieperhoff, S., Wilson, K. S., Baily, J., de Mora, K., Maqsood, S., Vass, S., Taylor, J., Del-Pozo, J., MacRae, C. A., Mullins, J. J., & Denvir, M. A. (2014). Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture. PLOS ONE, 9(5), Article e96771. https://doi.org/10.1371/journal.pone.0096771

The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated beating adult zebrafish hearts in culture for long-term experiments. Excised whole adult zebrafis... Read More about Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture.

Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio) (2013)
Journal Article
Vass, S., & Heck, M. M. S. (2013). Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio). Experimental Cell Research, 319(8), 1198-1212. https://doi.org/10.1016/j.yexcr.2013.02.005

Invadolysin is an essential, conserved metalloprotease which links cell division with cell migration and is intriguingly associated with lipid droplets. In this work we examine the expression pattern, protein localisation and gross anatomical consequ... Read More about Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio).

Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling (2012)
Journal Article
Bolukbasi, E., Vass, S., Cobbe, N., Nelson, B., Simossis, V., Dunbar, D. R., & Heck, M. M. S. (2012). Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biology, 2(1), 110031-110031. https://doi.org/10.1098/rsob.110031

Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalling is a highly conserved pathway that mediates this link. Herein, we descri... Read More about Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.

The conserved metalloprotease invadolysin localizes to the surface of lipid droplets (2009)
Journal Article
Cobbe, N., Marshall, K. M., Rao, S. G., Chang, C.-W., Di Cara, F., Duca, E., Vass, S., Kassan, A., & Heck, M. M. (2009). The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. Journal of Cell Science, 122(18), 3414-3423. https://doi.org/10.1242/jcs.044610

Invadolysin is a metalloprotease conserved in many different organisms, previously shown to be essential in Drosophila with roles in cell division and cell migration. The gene seems to be ubiquitously expressed and four distinct splice variants have... Read More about The conserved metalloprotease invadolysin localizes to the surface of lipid droplets.

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells (2007)
Journal Article
Crevel, G., Hashimoto, R., Vass, S., Sherkow, J., Yamaguchi, M., Heck, M. M., & Cotterill, S. (2007). Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. PLOS ONE, 2(9), Article e833. https://doi.org/10.1371/journal.pone.0000833

Background

The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular conte... Read More about Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells.