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From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring? (2023)
Presentation / Conference Contribution
Russo, G. (2023, September). From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?. Presented at 10th IAPC Meeting, Belgrade, Serbia

Biomimetic chromatography encompasses a range of analytical approaches aimed at mimicking the asset of biological membranes including – but not limited to – micellar liquid chromatography (MLC), immobilized artificial membranes (IAM) and immobilize... Read More about From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?.

High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC (2023)
Journal Article
Russo, G., Kajtazi, A., Vallaro, M., Surmont, P., Ermondi, G., Anderson, S., Grumetto, L., Caron, G., & Lynen, F. (2023). High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC. Journal of Pharmaceutical and Biomedical Analysis, 235, Article 115604. https://doi.org/10.1016/j.jpba.2023.115604

The charge state of a molecule is the single most prominent attribute ruling out its interactions with the surrounding environment. In a previous study, the retention of acids on the new Celeris™ Arginine (ARG) column was found to b... Read More about High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC.

Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction (2023)
Journal Article
Kajtazi, A., Russo, G., Wicht, K., Eghbali, H., & Lynen, F. (2023). Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction. Chemosphere, 337, Article 139361. https://doi.org/10.1016/j.chemosphere.2023.139361

Implementing effective environmental management strategies requires a comprehensive understanding of the chemical composition of environmental pollutants, particularly in complex mixtures. Utilizing innovative analytical techniques, such as high-reso... Read More about Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction.

The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption (2023)
Presentation / Conference Contribution
Dillon, A., Orzek, D., MacCallum, J., & Russo, G. (2023, June). The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption. Poster presented at HPLC 2023

Nowadays immobilized artificial membranes (IAM) are commonly used for modelling drug
transport through biological lipid layers. In most published studies a compound’s lipophilicity
measurements are performed in isocratic conditions where a low pe... Read More about The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption.

Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors (2022)
Journal Article
Russo, G., Piccolo, M., Neri, I., Ferraro, M. G., Santamaria, R., & Grumetto, L. (2023). Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors. Chemosphere, 313, Article 137569. https://doi.org/10.1016/j.chemosphere.2022.137569

Endocrine disruptors are chemicals widely used worldwide by industries in a variety of applications. Routinely exposure to these chemicals, even if at low doses, can cause damage effects on human health. In the present study, we evaluated toxic effec... Read More about Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors.

Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., Panariello, I., Rocco, D., Pezzullo, L., & Vitale, M. (2023). Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients. Environmental Pollution, 316, Article 120478. https://doi.org/10.1016/j.envpol.2022.120478

Bisphenol A (BPA) is a widespread thyroid disruptor, but evidence about an association with thyroid cancer is weak. Excess body weight is a risk factor for thyroid cancer and affects activity of endocrine disruptors. Aim of the study was to investiga... Read More about Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients.

Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers (2022)
Journal Article
Di Lorenzo, R., Neri, I., Russo, G., Laneri, S., & Grumetto, L. (2022). Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers. Cosmetics, 9(5), Article 102. https://doi.org/10.3390/cosmetics9050102

A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also... Read More about Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers.

Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography (2022)
Journal Article
Neri, I., Laneri, S., Di Lorenzo, R., Dini, I., Russo, G., & Grumetto, L. (2022). Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography. Molecules, 27(13), Article 4263. https://doi.org/10.3390/molecules27134263

Parabens (PBs) are used as preservatives to extend the shelf life of various foodstuffs, and pharmaceutical and cosmetic preparations. In this work, the membrane barrier passage potential of a subset of seven parabens, i.e., methyl-, ethyl-, propyl-... Read More about Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography.