Outputs (4)

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling (2012)
Journal Article
Sandilands, E., Serrels, B., McEwan, D. G., Morton, J. P., Macagno, J. P., McLeod, K., Stevens, C., Brunton, V. G., Langdon, W. Y., Vidal, M., Sansom, O. J., Dikic, I., Wilkinson, S., & Frame, M. C. (2012). Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nature Cell Biology, 14(1), 51-60. https://doi.org/10.1038/ncb2386

Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK pathway is severely perturbed. Depletion of FAK, detachment of FAK-proficient cells or expression of non-phosphorylatable FAK proteins causes sequestration of... Read More about Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

A role for vimentin in Crohn disease (2012)
Journal Article
Henderson, P., Wilson, D. C., Satsangi, J., & Stevens, C. (2012). A role for vimentin in Crohn disease. Autophagy, 8(11), 1695-1696. https://doi.org/10.4161/auto.21690

Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of studies have now demonstrated that genetic predisposition, environmental... Read More about A role for vimentin in Crohn disease.

The Role of Autophagy in Crohn’s Disease (2012)
Journal Article
Henderson, P., & Stevens, C. (2012). The Role of Autophagy in Crohn’s Disease. Cells, 1(3), 492-519. https://doi.org/10.3390/cells1030492

(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide associ... Read More about The Role of Autophagy in Crohn’s Disease.

The intermediate filament protein, vimentin, is a regulator of NOD2 activity (2012)
Journal Article
Stevens, C., Henderson, P., Nimmo, E. R., Soares, D. C., Dogan, B., Simpson, K. W., Barrett, J. C., Wilson, D. C., & Satsangi, J. (2013). The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut, 62(5), 695-707. https://doi.org/10.1136/gutjnl-2011-301775

Objective Mutations in the nucleotide-binding oligomerisation domain-containing protein 2 (NOD2) gene remain the strongest genetic determinants for Crohn's disease (CD). Having previously identified vimentin as a novel NOD2-interacting protein, the a... Read More about The intermediate filament protein, vimentin, is a regulator of NOD2 activity.