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Outputs (50)

P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration (2009)
Presentation / Conference Contribution
Ramage, L., Hardingham, G., & Salter, D. (2009, June). P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration. Paper presented at 2nd Joint meeting of the Bone Research Society and the British Society for Matrix Biology

NMDA receptors (NMDAR) are expressed by chondrocytes in articular cartilage although their function is yet to be fully understood. NMDAR are ionotropic glutamate receptors which when excessively stimulated in neurones induce cell death and neuron... Read More about P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration.

NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins (2008)
Presentation / Conference Contribution
Ramage, L., Hardingham, G., & Salter, D. (2008, September). NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins. Presented at 2008 World Congress on Osteoarthritis, Rome, Italy

Purpose: Osteoarthritis (OA) is associated with abnormal loading of articular joints. In normal joints physiological loading maintains structure and function of cartilage and chondrocytes within. This is mediated by a process known as mechanotransduc... Read More about NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins.

Taxonomy for Understanding Knowledge Captured in Documents By Designers (2007)
Presentation / Conference Contribution
Vijaykumar, G. A., & Chakrabarti, A. (2007). Taxonomy for Understanding Knowledge Captured in Documents By Designers. In DS 42: Proceedings of ICED 2007, the 16th International Conference on Engineering Design

In this competitive scenario of product development, product success is substantially influenced by satisfaction of the knowledge needs of designers. In literature many tools and methods are proposed to support satisfaction of these needs. But, adopt... Read More about Taxonomy for Understanding Knowledge Captured in Documents By Designers.

P214 NMDA receptor signalling in human osteoarthritic chondrocytes. (2007)
Presentation / Conference Contribution
Ramage, L., Hardingham, G., & Salter, D. (2007, September). P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Presented at ICRS 2007, Warsaw, Poland

Purpose: Human OA chondrocytes are known to express several subunits of the NMDA receptor (NMDAR), a neuronal signalling molecule. This study analyses downstream activation events and interactions of NMDAR with molecules known to be involved in chond... Read More about P214 NMDA receptor signalling in human osteoarthritic chondrocytes..

P186 Expression of functional NMDA receptors in human OA chondrocytes (2007)
Presentation / Conference Contribution
Ramage, L., Martel, M.-A., Hardingham, G., & Salter, D. (2006, December). P186 Expression of functional NMDA receptors in human OA chondrocytes. Presented at 2006 World Congress on Osteoarthritis, Prague, Czechia

Purpose: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and are being shown to have roles in regulation of chondrocyte function. This study looks at the expression and function of the metab... Read More about P186 Expression of functional NMDA receptors in human OA chondrocytes.

Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549) (2004)
Presentation / Conference Contribution
Ramage, L., Jones, A., & Whelan, C. Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549)

Cigarette smoke is known to be a complex mixture of >4000 constituents dispersed between the volatile and non-volatile phase, and inhaled exposure causes lung inflammation and cell injury. Here we investigate the effects of some of components of ciga... Read More about Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549).