Outputs (2388)

The STR/ort mouse model of spontaneous osteoarthritis – an update (2016)
Journal Article
Staines, K. A., Poulet, B., Wentworth, D. N., & Pitsillides, A. A. (2017). The STR/ort mouse model of spontaneous osteoarthritis – an update. Osteoarthritis and Cartilage, 25(6), 802-808. https://doi.org/10.1016/j.joca.2016.12.014

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are curr... Read More about The STR/ort mouse model of spontaneous osteoarthritis – an update.

The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis (2017)
Journal Article
Bordon, N., O'Rourke, S., & Hutton, P. (2017). The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis. Schizophrenia Research, 188, 3-12. https://doi.org/10.1016/j.schres.2017.01.014

Background People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psych... Read More about The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis.

An ecosystems perspective on international human resource development (IHRD): a meta-synthesis of the literature. (2019)
Journal Article
Garavan, T., McCarthy, A., & Carbery, R. (2019). An ecosystems perspective on international human resource development (IHRD): a meta-synthesis of the literature. Human Resource Development Review, 18(2), 248-288. https://doi.org/10.1177/1534484319828865

There has been significant growth of interest in both international human resource development (IHRD) and ecosystems research. Both literatures highlight important characteristics of each concept; however, to date, they have not yet been linked. We p... Read More about An ecosystems perspective on international human resource development (IHRD): a meta-synthesis of the literature..

Autism and Visual Impairment: a Review of the Literature (2017)
Journal Article
Butchart, M., Long, J. J., Brown, M., McMillan, A., Bain, J., & Karatzias, T. (2017). Autism and Visual Impairment: a Review of the Literature. Review Journal of Autism and Developmental Disorders, 4(2), 118-131. https://doi.org/10.1007/s40489-016-0101-1

Purpose This review presents the evidence on the prevalence of visual impairments in children and adults with Autism Spectrum Disorder (ASD), and the similar behavioural traits associated with both visual impairment and autism. Method A systemat... Read More about Autism and Visual Impairment: a Review of the Literature.

Implementation of a consumer-focused eHealth intervention for people with moderate-to-high cardiovascular disease risk: protocol for a mixed-methods process evaluation (2017)
Journal Article
Coorey, G. M., Neubeck, L., Usherwood, T., Peiris, D., Parker, S., Lau, A. Y. S., Chow, C., Panaretto, K., Harris, M., Zwar, N., & Redfern, J. (2017). Implementation of a consumer-focused eHealth intervention for people with moderate-to-high cardiovascular disease risk: protocol for a mixed-methods process evaluation. BMJ Open, 7(1), Article e014353. https://doi.org/10.1136/bmjopen-2016-014353

Technology-mediated strategies have potential to engage patients in modifying unhealthy behaviour and improving medication adherence to reduce morbidity and mortality from cardiovascular disease (CVD). Furthermore, electronic tools offer a medium by... Read More about Implementation of a consumer-focused eHealth intervention for people with moderate-to-high cardiovascular disease risk: protocol for a mixed-methods process evaluation.

A review of the impact of utilising electronic medical records for clinical research recruitment (2019)
Journal Article
Lai, Y. S., & Afseth, J. D. (2019). A review of the impact of utilising electronic medical records for clinical research recruitment. Clinical Trials, 16(2), 194-203. https://doi.org/10.1177/1740774519829709

Introduction: Recruitment is an important aspect of clinical research, as poor recruitment could undermine the scientific value of a trial or delay the development process of new treatments. The development of electronic medical records provides a n... Read More about A review of the impact of utilising electronic medical records for clinical research recruitment.

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification (2016)
Journal Article
Houston, D. A., Staines, K. A., MacRae, V. E., & Farquharson, C. (2016). Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification. Journal of Visualized Experiments, 118(118), Article e54978. https://doi.org/10.3791/54978

The fundamental process of endochondral ossification is under tight regulation in the healthy individual so as to prevent disturbed development and/or longitudinal bone growth. As such, it is imperative that we further our understanding of the underp... Read More about Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification.

Analyzing Objective and Subjective Data in Social Sciences: Implications for Smart Cities (2019)
Journal Article
Erhan, L., Ndubuaku, M., Ferrara, E., Richardson, M., Sheffield, D., Ferguson, F. J., Brindley, P., & Liotta, A. (2019). Analyzing Objective and Subjective Data in Social Sciences: Implications for Smart Cities. IEEE Access, 7, 19890-19906. https://doi.org/10.1109/access.2019.2897217

The ease of deployment of digital technologies and the Internet of Things gives us the opportunity to carry out large-scale social studies and to collect vast amounts of data from our cities. In this paper, we investigate a novel way of analyzing dat... Read More about Analyzing Objective and Subjective Data in Social Sciences: Implications for Smart Cities.

E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models (2015)
Journal Article
Staines, K. A., Prideaux, M., Allen, S., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2016). E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. Journal of Cellular Physiology, 231(6), 1392-1404. https://doi.org/10.1002/jcp.25282

The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO-A5 cell line we reveal increased E... Read More about E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity (2016)
Journal Article
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., Sampson, A., Nakamura, H., Nagase, H., Carriero, A., Shefelbine, S., Pitsillides, A. A., & Bou-Gharios, G. (2016). Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLOS ONE, 11(12), Article e0167971. https://doi.org/10.1371/journal.pone.0167971

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting... Read More about Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model (2016)
Journal Article
Staines, K. A., Madi, K., Mirczuk, S. M., Parker, S., Burleigh, A., Poulet, B., Hopkinson, M., Bodey, A. J., Fowkes, R. C., Farquharson, C., Lee, P. D., & Pitsillides, A. A. (2016). Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model. Arthritis and Rheumatology, 68(4), 880-891. https://doi.org/10.1002/art.39508

OBJECTIVE: To explore whether aberrant transient chondrocyte behaviors occur in the joints of STR/Ort mice (which spontaneously develop osteoarthritis [OA]) and whether they are attributable to an endochondral growth defect. METHODS: Knee joints f... Read More about Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model.

The Influence of Age, Cardiorespiratory Fitness, Exercise and Sedentary Behaviours on Circulating Angiogenic Cells and Cell Surface Receptor Expression (2016)
Thesis
Ross, M. D. (2016). The Influence of Age, Cardiorespiratory Fitness, Exercise and Sedentary Behaviours on Circulating Angiogenic Cells and Cell Surface Receptor Expression. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/462603

Cardiovascular disease (CVD) is the biggest killer of people in western civilisation. Age is a significant risk factor for the development for CVD, and treatments and therapies to address this increased risk are crucial to quality of life and longevi... Read More about The Influence of Age, Cardiorespiratory Fitness, Exercise and Sedentary Behaviours on Circulating Angiogenic Cells and Cell Surface Receptor Expression.

Automation enhancement and accuracy investigation of a portable single-camera gait analysis system (2019)
Journal Article
Yang, C., Ugbolue, U. C., McNicol, D., Stankovic, V., Stankovic, L., Kerr, A., Carse, B., Kaliarntas, K., & Rowe, P. J. (2019). Automation enhancement and accuracy investigation of a portable single-camera gait analysis system. IET Science, Measurements and Technology, 13(4), 563-571. https://doi.org/10.1049/iet-smt.2018.5246

While optical motion analysis systems can provide high-fidelity gait parameters, they are usually impractical for local clinics and home use, due to high cost, requirement for large space, and lack of portability. In this study, the authors focus on... Read More about Automation enhancement and accuracy investigation of a portable single-camera gait analysis system.

Midwives' experience of offering anti-D immunoglobulin to women: The importance of choice (2016)
Journal Article
Harkness, M., Freer, Y., & Warner, P. (2016). Midwives' experience of offering anti-D immunoglobulin to women: The importance of choice. British Journal of Midwifery, 24(7), 500-505. https://doi.org/10.12968/bjom.2016.24.7.500

Background Informed decision making around anti-D immunoglobulin (Ig) is important but complex, requiring consideration of individual factors to reach the most appropriate choices for individual women. This research aimed to develop understanding of... Read More about Midwives' experience of offering anti-D immunoglobulin to women: The importance of choice.

Patient Reported Outcome Measure of Spiritual Care as Delivered by Chaplains (2017)
Journal Article
Snowden, A., & Telfer, I. (2017). Patient Reported Outcome Measure of Spiritual Care as Delivered by Chaplains. Journal of Health Care Chaplaincy, 23(4), 131-155. https://doi.org/10.1080/08854726.2017.1279935

Chaplains are employed by health organizations around the world to support patients in recognizing and addressing their spiritual needs. There is currently no generalizable measure of the impact of these interventions and so the clinical and strategi... Read More about Patient Reported Outcome Measure of Spiritual Care as Delivered by Chaplains.

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., Benavides, J., Palarea-Albaladejo, J., Mcinnes, C. J., Ballingall, K., & Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

The effects of high-intensity exercise on neural responses to images of food (2013)
Journal Article
Crabtree, D. R., Chambers, E. S., Hardwick, R. M., & Blannin, A. K. (2014). The effects of high-intensity exercise on neural responses to images of food. American Journal of Clinical Nutrition, 99(2), 258-267. https://doi.org/10.3945/ajcn.113.071381

Background: Acute bouts of high-intensity exercise modulate peripheral appetite regulating hormones to transiently suppress hunger. However, the effects of physical activity on central appetite regulation have yet to be fully investigated. Objectiv... Read More about The effects of high-intensity exercise on neural responses to images of food.

Effects of Exercise in the Cold on Ghrelin, PYY, and Food Intake in Overweight Adults (2015)
Journal Article
Crabtree, D. R., & Blannin, A. K. (2015). Effects of Exercise in the Cold on Ghrelin, PYY, and Food Intake in Overweight Adults. Medicine and Science in Sports and Exercise, 47(1), 49-57. https://doi.org/10.1249/mss.0000000000000391

Purpose: Exercise in cold water has been shown to simulate postexercise energy intake (EI) in normal-weight individuals. However, the effect of cold exercise on EI in overweight individuals has yet to be examined. The present study investigated the e... Read More about Effects of Exercise in the Cold on Ghrelin, PYY, and Food Intake in Overweight Adults.

Patterns of referral and waiting times for specialist Child and Adolescent Mental Health Services (2017)
Journal Article
Smith, J., Kyle, R. G., Daniel, B., & Hubbard, G. (2018). Patterns of referral and waiting times for specialist Child and Adolescent Mental Health Services. Child and Adolescent Mental Health, 23(1), 41-49. https://doi.org/10.1111/camh.12207

Background During 12 month period (2012/13) around 21,480 children and young people (CYP) were referred to CAMHS in Scotland (NHS Scotland 2013). At the end of September 2012 there were 3,602 CYP still waiting for ‘start of treatment’ or ‘removal fr... Read More about Patterns of referral and waiting times for specialist Child and Adolescent Mental Health Services.

Education and interprofessional learning (2013)
Presentation / Conference Contribution
Dosser, I., & Nicol, J. (2013, September). Education and interprofessional learning. Presented at International Reflective Practice Conference 2013, Sketty Hall, Swansea, South Wales, UK

Benefits and challenges of reflection in an undergraduate nursing programme