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The STR/ort mouse model of spontaneous osteoarthritis – an update

Staines, K A; Poulet, B; Wentworth, D N; Pitsillides, A A

Authors

K A Staines

B Poulet

D N Wentworth

A A Pitsillides



Abstract

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.

Journal Article Type Article
Acceptance Date Dec 7, 2016
Online Publication Date Dec 11, 2016
Publication Date 2017-06
Deposit Date Jun 9, 2017
Publicly Available Date Jun 9, 2017
Journal Osteoarthritis and Cartilage
Print ISSN 1063-4584
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Issue 6
Pages 802-808
DOI https://doi.org/10.1016/j.joca.2016.12.014
Keywords STR/ort, Osteoarthritis, Articular cartilage, Subchondral bone
Public URL http://researchrepository.napier.ac.uk/Output/459760
Contract Date Jun 9, 2017

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