The STR/ort mouse model of spontaneous osteoarthritis – an update

Staines, K A; Poulet, B; Wentworth, D N; Pitsillides, A A

Abstract

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes.

Citation

Staines, K. A., Poulet, B., Wentworth, D. N., & Pitsillides, A. A. (2017). The STR/ort mouse model of spontaneous osteoarthritis – an update. Osteoarthritis and Cartilage, 25(6), 802-808. https://doi.org/10.1016/j.joca.2016.12.014

• Journal Article Type: Article
• Acceptance Date: Dec 7, 2016
• Online Publication Date: Dec 11, 2016
• Publication Date: 2017-06
• Deposit Date: Jun 9, 2017
• Publicly Available Date: Jun 9, 2017
• Journal: Osteoarthritis and Cartilage
• Print ISSN: 1063-4584
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 25
• Issue: 6
• Pages: 802-808
• DOI: https://doi.org/10.1016/j.joca.2016.12.014
• Keywords: STR/ort, Osteoarthritis, Articular cartilage, Subchondral bone
• Public URL: http://researchrepository.napier.ac.uk/Output/459760
• Contract Date: Jun 9, 2017