Outputs (9)

Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion (2021)
Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., Wilson, K., Chianini, F., Silvia Rocchi, M., Wheelhouse, N., Entrican, G., & Longbottom, D. (2021). Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), Article 898. https://doi.org/10.3390/vaccines9080898

Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of... Read More about Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion.

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study (2019)
Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), Article 992. https://doi.org/10.1186/s12889-019-7313-0

Background
Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital tract, C. trachomatis is found in the throat and rectum, suggesting the n... Read More about Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study.

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., Benavides, J., Palarea-Albaladejo, J., Mcinnes, C. J., Ballingall, K., & Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

Ferlavirus-related deaths in a collection of viperid snakes (2018)
Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., Orós, J., Pocknell, A., Rendle, M. E., Strike, T., Tapley, B., & Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1

Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were from the main zoo collection, but the other 24 had been imported and quarantin... Read More about Ferlavirus-related deaths in a collection of viperid snakes.

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment (2018)
Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., Entrican, G., McFee, S., Wills, G. S., McClure, M. O., Horner, P. J., Gaikoumelou, S., Lee, K. F., Critchley, H. O., Duncan, W. C., & Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is uncle... Read More about Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain (2017)
Journal Article
Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., Van Winden, S., Green, M., & Guitian, J. (2017). Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), 9215-9233. https://doi.org/10.3168/jds.2016-11863

To implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this study was to estimate the prevalence of selected endemic infectious diseases in th... Read More about Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain.

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release (2017)
Journal Article
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., Saunders, P. T. K., Horner, P., Entrican, G., Howie, S. E. M., & Horne, A. W. (2017). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), Article 2001. https://doi.org/10.1038/s41598-017-02223-z

Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires end... Read More about Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS (2017)
Journal Article
Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., Wattegedera, S., Wilson, K., Sait, M., Siarkou, V., Vretou, E., Entrican, G., Dagleish, M., & Longbottom, D. (2017). Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLOS ONE, 12(5), Article e0177653. https://doi.org/10.1371/journal.pone.0177653

This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be responsible for late term abortion in small ruminants. Challenge with the thr... Read More about Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS.

Ovine trophoblasts express cathelicidin host defence peptide in response to infection (2016)
Journal Article
Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., Colin Duncan, W., Rae, M. T., & Barlow, P. G. (2016). Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology, 117, 10-16. https://doi.org/10.1016/j.jri.2016.06.006

Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placental trophoblast in ovine host defence remains poorly understood. This study... Read More about Ovine trophoblasts express cathelicidin host defence peptide in response to infection.