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Outputs (69)

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK (2019)
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., Henderson, P., & Stevens, C. (2019). The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammat

Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD)... Read More about The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK.

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., Benavides, J., Palarea-Albaladejo, J., Mcinnes, C. J., Ballingall, K., & Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the deg

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

Ferlavirus-related deaths in a collection of viperid snakes (2018)
Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., Orós, J., Pocknell, A., Rendle, M. E., Strike, T., Tapley, B., & Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo

Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were from the main zoo collection, but the other 24 had been imported and quarantin... Read More about Ferlavirus-related deaths in a collection of viperid snakes.

Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease (2018)
Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019). Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy3

Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology involves a combination of genetic and environmental factors resulting in a... Read More about Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease.

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain (2017)
Journal Article
Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017). Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), 9215-9233. h

To implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this study was to estimate the prevalence of selected endemic infectious diseases in th... Read More about Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain.

The feasibility and acceptability of trial procedures for a pragmatic randomised controlled trial of a structured physical activity intervention for people diagnosed with colorectal cancer: findings from a pilot trial of cardiac rehabilitation versus usual care (no rehabilitation) with an embedded qualitative study. (2016)
Journal Article
Hubbard, G., O’Carroll, R., Munro, J., Mutrie, N., Haw, S., Mason, H., & Treweek, S. (2016). The feasibility and acceptability of trial procedures for a pragmatic randomised controlled trial of a structured physical activity intervention for people diag

Background: Pilot and feasibility work is conducted to evaluate the operational feasibility and acceptability of the intervention itself and the feasibility and acceptability of a trials’ protocol design. The Cardiac Rehabilitation In Bowel cancer (C... Read More about The feasibility and acceptability of trial procedures for a pragmatic randomised controlled trial of a structured physical activity intervention for people diagnosed with colorectal cancer: findings from a pilot trial of cardiac rehabilitation versus usual care (no rehabilitation) with an embedded qualitative study..

Estimating excess length of stay due to healthcare-associated infections: A systematic review and meta-analysis of statistical methodology (2018)
Journal Article
Manoukian, S., Stewart, S., Dancer, S., Graves, N., Mason, H., McFarland, A., Robertson, C., & Reilly, J. (2018). Estimating excess length of stay due to healthcare-associated infections: A systematic review and meta-analysis of statistical methodology. J

Background Healthcare-associated infection (HAI) affects millions of patients worldwide. HAI is associated with increased healthcare costs, owing primarily to increased hospital length of stay (LOS) but calculating these costs is complicated due to... Read More about Estimating excess length of stay due to healthcare-associated infections: A systematic review and meta-analysis of statistical methodology.

Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment (2018)
Journal Article
Boukelia, Z., Gomes, E. C., & Florida-James, G. D. (2018). Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment. Oxidative Medicine and Cellular Longevity, 2018, Article 340214

Purpose. The purpose of this study was to investigate the physiological and immunological response of highly trained runners to an intense bout of exercise performed at two different times of day, in a hot, humid environment. Methods. Using a crossov... Read More about Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment.

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration (2017)
Journal Article
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., Proudfoot, L., & Barlow, P. G. (2017). Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immuno

Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity is the human cathelicidin, LL-37. LL-37 has been shown to be upregulated at... Read More about Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration.

Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial (2017)
Journal Article
Pegington, M., Adams, J. E., Bundred, N. J., Harvie, M. N., Campbell, A., Howell, A., …Harvey, M. (2018). Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial. Integrative Cancer Therapies,

Excess weight at breast cancer diagnosis and weight gain during treatment are linked to increased breast cancer specific and all-cause mortality. The Breast—Activity and Healthy Eating After Diagnosis (B-AHEAD) trial tested 2 weight loss diet and exe... Read More about Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial.

Therapeutic Change in Group Therapy For Interpersonal Trauma: A Relational Framework for Research and Clinical Practice (2017)
Journal Article
Chouliara, Z., Karatzias, T., Gullone, A., Ferguson, S., Cosgrove, K., & Burke Draucker, C. (2020). Therapeutic Change in Group Therapy For Interpersonal Trauma: A Relational Framework for Research and Clinical Practice. Journal of Interpersonal Violence,

Our understanding of therapeutic change processes in group therapy for complex interpersonal trauma has been limited. The present study aimed at addressing this gap by developing a framework of therapeutic change in this field from a survivor and the... Read More about Therapeutic Change in Group Therapy For Interpersonal Trauma: A Relational Framework for Research and Clinical Practice.

Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’ (2015)
Journal Article
Dancer, S. (2016). Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’. Journal of Hospital Infection, 92(2), 208-209. https://doi.org/10.1016/j.jhin.2015.10.020

Letter to Editor. Refers to - J.-Y. Maillard, S.A. Sattar, C. Bradley Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’ Journal of Hospital Infection, Volume 92, Issue 2, February 201... Read More about Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’.

Researching effective approaches to cleaning in hospitals: protocol of the REACH study, a multi-site stepped-wedge randomised trial (2016)
Journal Article
Hall, L., Farrington, A., Mitchell, B. G., Barnett, A. G., Halton, K., Allen, M., …Graves, N. (2016). Researching effective approaches to cleaning in hospitals: protocol of the REACH study, a multi-site stepped-wedge randomised trial. Implementation Sci

Background The Researching Effective Approaches to Cleaning in Hospitals (REACH) study will generate evidence about the effectiveness and cost-effectiveness of a novel cleaning initiative that aims to improve the environmental cleanliness of hospita... Read More about Researching effective approaches to cleaning in hospitals: protocol of the REACH study, a multi-site stepped-wedge randomised trial.

What's trending in infection control? (2017)
Journal Article
Mitchell, B. G., Petrie, D., Morton, L., & Dancer, S. J. (2017). What's trending in infection control?. Infection Control and Hospital Epidemiology, 38(9), 1098-1102. https://doi.org/10.1017/ice.2017.130

OBJECTIVE To explore the trends in infection control peer-reviewed journals, mainstream media, and blogs written by infection control professionals DESIGN Narrative and scoping reviews METHODS Narrative and scoping reviews were performed to identify... Read More about What's trending in infection control?.

Antibiotic prescribing: the consequences of getting it wrong (2016)
Journal Article
Dancer, S. J. (2016). Antibiotic prescribing: the consequences of getting it wrong. Clinical Focus Primary Care, 10(2), 62-71

Antibiotics were one of the most important discoveries last century. As with all drugs, however, they are associated with adverse effects. This article reviews how inappropriate antibiotic prescribing not only fails to cure an infected patient; it ma... Read More about Antibiotic prescribing: the consequences of getting it wrong.

Research priorities about stoma-related quality of life from the perspective of people with a stoma: A pilot survey (2017)
Journal Article
Hubbard, G., Taylor, C., Beeken, B., Campbell, A., Gracey, J., Grimmett, C., …Gorely, T. (2017). Research priorities about stoma-related quality of life from the perspective of people with a stoma: A pilot survey. Health Expectations, 20(6), 1421-1427.

Background:There is a recognized need to include patients in setting research priorities. Research priorities identified by people with a stoma are rarely elicited. Objectives: To improve the quality of life of people with a stoma through use of ev... Read More about Research priorities about stoma-related quality of life from the perspective of people with a stoma: A pilot survey.

Cathelicidins display conserved direct antiviral activity towards rhinovirus. (2017)
Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017). Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013

Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised individuals and patients with pre-existing pulmonary conditions. The therapeut... Read More about Cathelicidins display conserved direct antiviral activity towards rhinovirus..

Variation in hospital cleaning practice and process in Australian hospitals: A structured mapping exercise (2017)
Journal Article
Mitchell, B. G., Farrington, A., Allen, M., Gardner, A., Hall, L., Barnett, A. G., …Graves, N. (2017). Variation in hospital cleaning practice and process in Australian hospitals: A structured mapping exercise. Infection, Disease & Health, https://doi.o

Background The purpose of this paper is to highlight the range of cleaning practices and processes in 11 Australian hospitals and to discuss the challenges this variation poses to the implementation of clinical trials or changes to hospital cleaning... Read More about Variation in hospital cleaning practice and process in Australian hospitals: A structured mapping exercise.