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Prof Paul Hutton's Outputs (55)

Accelerating the development of a psychological intervention to restore treatment decision-making capacity in patients with schizophrenia-spectrum disorder: a study protocol for a multi-site, assessor-blinded, pilot Umbrella trial (the DEC:IDES trial) (2023)
Journal Article
Hutton, P., Kelly, J., Taylor, C. D., Williams, B., Emsley, R., Alexander, C. H., Vikram, A., Saddington, D., McCann, A., Burke, J., Eliasson, E., Harper, S., Karatzias, T., Taylor, P. J., Watson, A., Dougall, N., Stavert, J., O’Rourke, S., Glasgow, A., Murphy, R., …Woodrow, A. (2023). Accelerating the development of a psychological intervention to restore treatment decision-making capacity in patients with schizophrenia-spectrum disorder: a study protocol for a multi-site, assessor-blinded, pilot Umbrella trial (the DEC:IDES trial). Pilot and Feasibility Studies, 9, Article 117. https://doi.org/10.1186/s40814-023-01323-0

Background:
A high proportion of patients diagnosed with schizophrenia-spectrum disorders will at some point in their lives be assessed as not having the capacity to make their own decisions about pharmacological treatment or inpatient care (‘capaci... Read More about Accelerating the development of a psychological intervention to restore treatment decision-making capacity in patients with schizophrenia-spectrum disorder: a study protocol for a multi-site, assessor-blinded, pilot Umbrella trial (the DEC:IDES trial).

Discerning the adverse effects of psychological therapy: consensus between experts by experience and therapists (2021)
Journal Article
McGlanaghy, E., Jackson, J., Morris, P., Prentice, W., Dougall, N., & Hutton, P. (2022). Discerning the adverse effects of psychological therapy: consensus between experts by experience and therapists. Clinical Psychology and Psychotherapy, 29(2), 579-589. https://doi.org/10.1002/cpp.2648

Measurement of adverse effects of psychological therapy is inconsistent due to ambiguity about the concept. The perspective of people undertaking psychological therapy (that is, experts by experience) has largely been overlooked. This study will inve... Read More about Discerning the adverse effects of psychological therapy: consensus between experts by experience and therapists.

A network meta-analysis of psychological interventions for schizophrenia and psychosis: impact on symptoms (2021)
Journal Article
Mc Glanaghy, E., Turner, D., Davis, G. A., Sharpe, H., Dougall, N., Morris, P., Prentice, W., & Hutton, P. (2021). A network meta-analysis of psychological interventions for schizophrenia and psychosis: impact on symptoms. Schizophrenia Research, 228, https://doi.org/10.1016/j.schres.2020.12.036

Background: Evidence for the effectiveness of psychological interventions for schizophrenia/psychosis is growing, however there is no consensus on the psychological intervention most likely to reduce symptoms.

Methods: A network meta-analysis was... Read More about A network meta-analysis of psychological interventions for schizophrenia and psychosis: impact on symptoms.

Psychological interventions for ICD-11 Complex PTSD symptoms: Systematic review and meta-analysis (2019)
Journal Article
Karatzias, T., Murphy, P., Cloitre, M., Bisson, J., Roberts, N., Shevlin, M., Hyland, P., Maercker, A., Ben-Ezra, M., Coventry, P., Mason-Roberts, S., Bradley, A., & Hutton, P. (2019). Psychological interventions for ICD-11 Complex PTSD symptoms: Systematic review and meta-analysis. Psychological Medicine, 49(11), 1761-1775. https://doi.org/10.1017/S0033291719000436

Background: The 11th revision to the WHO International Classification of Diseases (ICD-11) identified Complex Posttraumatic Stress Disorder (CPTSD) as a new condition. There is a pressing need to identify effective CPTSD interventions. Methods: We co... Read More about Psychological interventions for ICD-11 Complex PTSD symptoms: Systematic review and meta-analysis.

Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT (2019)
Journal Article
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S., French, P., Hutton, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R., Davies, L., Shields, G., Buck, D., …Kingdon, D. (2019). Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT. Health Technology Assessment, 23(7), 1-144. https://doi.org/10.3310/hta23070

Background: Clozapine (clozaril, Mylan Products Ltd) is a first-choice treatment for people withschizophrenia who have a poor response to standard antipsychotic medication. However, a significant number of patients who trial clozapine have an inadequ... Read More about Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT.

A feasibility study of a cross-diagnostic, CBT-based psychological intervention for acute mental health inpatients: Results, challenges, and methodological implications (2018)
Journal Article
Paterson, C., Karatzias, T., Harper, S., Dougall, N., Dickson, A., & Hutton, P. (2019). A feasibility study of a cross-diagnostic, CBT-based psychological intervention for acute mental health inpatients: Results, challenges, and methodological implications. British Journal of Clinical Psychology, 58(2), 211-230. https://doi.org/10.1111/bjc.12209

Objectives
Acute psychiatric inpatient wards are characterised by minimal provision of therapeutic activities and high readmission rates. Implementation of a comprehensive inpatient psychological intervention service has been recommended to overcome... Read More about A feasibility study of a cross-diagnostic, CBT-based psychological intervention for acute mental health inpatients: Results, challenges, and methodological implications.

Suicidal ideation in people with psychosis not taking antipsychotic medication: Do negative appraisals and negative metacognitive beliefs mediate the effect of symptoms? (2018)
Journal Article
Hutton, P., Di Rienzo, F., Turkington, D., Spencer, H., & Taylor, P. (2019). Suicidal ideation in people with psychosis not taking antipsychotic medication: Do negative appraisals and negative metacognitive beliefs mediate the effect of symptoms?. Schizophrenia Bulletin, 45(1), 37-47. https://doi.org/10.1093/schbul/sby153

Between 5 and 10 percent of people with psychosis will die by suicide, a rate which is 20 to 75 times higher than the general population. This risk is even greater in those not taking antipsychotic medication. We examined whether negative appraisals... Read More about Suicidal ideation in people with psychosis not taking antipsychotic medication: Do negative appraisals and negative metacognitive beliefs mediate the effect of symptoms?.

The paranoia as defence model of persecutory delusions: a systematic review and meta-analysis (2018)
Journal Article
Murphy, P., Bentall, R. P., Freeman, D., O'Rourke, S., & Hutton, P. (2018). The paranoia as defence model of persecutory delusions: a systematic review and meta-analysis. Lancet Psychiatry, 5(11), 913-929. https://doi.org/10.1016/S2215-0366%2818%2930339-0

Background
An influential psychological model of persecutory delusions proposed they are caused by a bias towards holding others responsible for negative events, which serves to prevent underlying low self-esteem from reaching awareness. An early (1... Read More about The paranoia as defence model of persecutory delusions: a systematic review and meta-analysis.

The effect of reducing the 'jumping to conclusions' bias on treatment decision-making capacity in psychosis: A randomised controlled trial with mediation analysis (2018)
Journal Article
Turner, D. T., MacBeth, A., Larkin, A., Moritz, S., Livingstone, K., Campbell, A., & Hutton, P. (2019). The effect of reducing the 'jumping to conclusions' bias on treatment decision-making capacity in psychosis: A randomised controlled trial with mediation analysis. Schizophrenia Bulletin, 45(4), 784-793. https://doi.org/10.1093/schbul/sby136

Background
Evidence-based psychological interventions to support treatment decision-making capacity (‘capacity’) in psychosis do not currently exist. This study sought to establish whether reducing the extent to which this group form conclusions bas... Read More about The effect of reducing the 'jumping to conclusions' bias on treatment decision-making capacity in psychosis: A randomised controlled trial with mediation analysis.

Decision-making ability in psychosis: a systematic review and meta-analysis of the magnitude, specificity and correlates of impaired performance on the Iowa and Cambridge Gambling Tasks (2018)
Journal Article
Woodrow, A., Sparks, S., Bobrovskaia, V., Paterson, C., Murphy, P., & Hutton, P. (2019). Decision-making ability in psychosis: a systematic review and meta-analysis of the magnitude, specificity and correlates of impaired performance on the Iowa and Cambridge Gambling Tasks. Psychological Medicine, 49(1), 32-48. https://doi.org/10.1017/S0033291718002660

To identify factors which may help or hinder decision-making ability in people with psychosis, we did a systematic review and meta-analysis of their performance on the Iowa and Cambridge Gambling Tasks. Analysis of 47 samples found they had moderatel... Read More about Decision-making ability in psychosis: a systematic review and meta-analysis of the magnitude, specificity and correlates of impaired performance on the Iowa and Cambridge Gambling Tasks.

A systematic review and meta-analysis of group treatments for adults with symptoms associated with complex post-traumatic stress disorder (2018)
Journal Article
Mahoney, A., Karatzias, T., & Hutton, P. (2018). A systematic review and meta-analysis of group treatments for adults with symptoms associated with complex post-traumatic stress disorder. Journal of Affective Disorders, https://doi.org/10.1016/j.jad.2018.09.059

Background: No previous meta-analyses have specifically investigated the effectiveness of psychological group therapy for symptoms associated with complex interpersonal trauma, including whether trauma memory processing (TMP) therapies are superior t... Read More about A systematic review and meta-analysis of group treatments for adults with symptoms associated with complex post-traumatic stress disorder.

Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome? (2018)
Journal Article
Spencer, H. M., McMenamin, M., Emsley, R., Turkington, D., Dunn, G., Morrison, A. P., Brabban, A., Hutton, P., & Dudley, R. (2018). Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?. Schizophrenia Research, 202, 385-386. https://doi.org/10.1016/j.schres.2018.07.016

This study investigated the effect of “dose” and the components of Cognitive Behavioral Therapy (CBT) on treatment effects. It is a secondary analysis of the ACTION (Assessment of Cognitive Therapy Instead of Neuroleptics) trial which investigated CB... Read More about Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?.

Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial (2018)
Journal Article
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S. E., French, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R. E., Davies, L., Kingdon, D., Aydinlar, S., Courtley, J., …Tully, S. (2018). Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial. Lancet Psychiatry, 5(8), 633-643. https://doi.org/10.1016/s2215-0366%2818%2930184-6

Background
Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30–40% of patients have an insufficient response, and others are unable to tolerate it. Evidence for any augmentation strategies is scarce. We aimed to... Read More about Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial.

Cognitive Analytic Therapy for Psychosis: A Case Series (2018)
Journal Article
Taylor, P. J., Taylor, P., Perry, A., Hutton, P., Tan, R., Fisher, N., Focone, C., Griffiths, D., & Seddon, C. (2019). Cognitive Analytic Therapy for Psychosis: A Case Series. Psychology and Psychotherapy: Theory, Research and Practice, 92(3), 359-378. https://doi.org/10.1111/papt.12183

Objectives: Cognitive Analytic Therapy (CAT) is an effective psychological intervention for several different mental health conditions. However, whether it is acceptable, safe and beneficial for people with psychosis remains unclear, as is the feasib... Read More about Cognitive Analytic Therapy for Psychosis: A Case Series.

Psychological therapy for inpatients receiving acute mental health care: A systematic review and meta-analysis of controlled trials (2018)
Journal Article
Paterson, C., Karatzias, T., Dickson, A., Harper, S., Dougall, N., & Hutton, P. (2018). Psychological therapy for inpatients receiving acute mental health care: A systematic review and meta-analysis of controlled trials. British Journal of Clinical Psychology, 57(4), 453-472. https://doi.org/10.1111/bjc.12182

Objectives
The effectiveness of psychological therapies for those receiving acute adult mental health inpatient care remains unclear, partly because of the difficulty in conducting randomised controlled trials (RCTs) in this setting. The aim of this... Read More about Psychological therapy for inpatients receiving acute mental health care: A systematic review and meta-analysis of controlled trials.

Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis (2017)
Journal Article
Larkin, A., & Hutton, P. (2017). Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis. British Journal of Psychiatry, 211(4), 205-215. https://doi.org/10.1192/bjp.bp.116.193458

Background: The evidence on factors that may influence treatment decisional capacity (‘capacity) in psychosis has yet to be comprehensively synthesised, which limits the development of effective strategies to improve or support it.
Aims: To determin... Read More about Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis.

Practitioner Review: Therapist variability, patient-reported therapeutic alliance, and clinical outcomes in adolescents undergoing mental health treatment - a systematic review and meta-analysis (2017)
Journal Article
Murphy, R., & Hutton, P. (2017). Practitioner Review: Therapist variability, patient-reported therapeutic alliance, and clinical outcomes in adolescents undergoing mental health treatment - a systematic review and meta-analysis. Journal of Child Psychology and Psychiatry, 59(1), 5-19. https://doi.org/10.1111/jcpp.12767

Background: Previous meta-analyses have only found small correlations (r=0.10 to r=0.19) between therapeutic alliance and clinical outcomes in samples of adolescents receiving psychological therapy. Although study-level variables have been found to m... Read More about Practitioner Review: Therapist variability, patient-reported therapeutic alliance, and clinical outcomes in adolescents undergoing mental health treatment - a systematic review and meta-analysis.

Loneliness in Psychosis: A Meta-analytical Review (2017)
Journal Article
Michalska da Rocha, B., Vasilopoulou, E., Rhodes, S., & Hutton, P. (2018). Loneliness in Psychosis: A Meta-analytical Review. Schizophrenia Bulletin, 44(1), 114-125. https://doi.org/10.1093/schbul/sbx036

Loneliness may be related to psychotic symptoms but a comprehensive synthesis of the literature in this area is lacking. The aim of the current study is to determine the magnitude and reliability of the loneliness-psychosis relationship in people dia... Read More about Loneliness in Psychosis: A Meta-analytical Review.

The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis (2017)
Journal Article
Bordon, N., O'Rourke, S., & Hutton, P. (2017). The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis. Schizophrenia Research, 188, 3-12. https://doi.org/10.1016/j.schres.2017.01.014

Background
People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psych... Read More about The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis.

Social cognition and paranoia in forensic inpatients with schizophrenia: A cross-sectional study (2016)
Journal Article
Bratton, H., O'Rourke, S., Tansey, L., & Hutton, P. (2016). Social cognition and paranoia in forensic inpatients with schizophrenia: A cross-sectional study. Schizophrenia Research, 184, 96-102. https://doi.org/10.1016/j.schres.2016.12.004

Background
People diagnosed with schizophrenia have difficulties in emotion recognition and theory of mind, and these may contribute to paranoia. The aim of this study was to determine whether this relationship is evident in patients residing in a s... Read More about Social cognition and paranoia in forensic inpatients with schizophrenia: A cross-sectional study.

Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial (2016)
Journal Article
Pyle, M., Schwannauer, M., Norrie, J., Kingdon, D., Gumley, A., Turkington, D., Byrne, R., Syrett, S., MacLennan, G., Dudley, R., McLeod, H. J., Griffiths, H., Bowe, S., Barnes, T. R. E., French, P., Hutton, P., Davies, L., & Morrison, A. P. (2016). Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial. BMC Psychiatry, 16(280), https://doi.org/10.1186/s12888-016-0983-6

Background

For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozap... Read More about Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial.

Shared treatment decision-making and empowerment-related outcomes in psychosis: systematic review and meta-analysis (2016)
Journal Article
Stovell, D., Morrison, A. P., Panayiotou, M., & Hutton, P. (2016). Shared treatment decision-making and empowerment-related outcomes in psychosis: systematic review and meta-analysis. British Journal of Psychiatry, 209(1), 23-28. https://doi.org/10.1192/bjp.bp.114.158931

BACKGROUND:
In the UK almost 60% of people with a diagnosis of schizophrenia who use mental health services say they are not involved in decisions about their treatment. Guidelines and policy documents recommend that shared decision-making should be... Read More about Shared treatment decision-making and empowerment-related outcomes in psychosis: systematic review and meta-analysis.

Cognitive therapy for internalised stigma in people experiencing psychosis: A pilot randomised controlled trial (2016)
Journal Article
Morrison, A. P., Burke, E., Murphy, E., Pyle, M., Bowe, S., Varese, F., Dunn, G., Chapman, N., Hutton, P., Welford, M., & Wood, L. J. (2016). Cognitive therapy for internalised stigma in people experiencing psychosis: A pilot randomised controlled trial. Psychiatry Research, 240(30), 96-102. https://doi.org/10.1016/j.psychres.2016.04.024

We aimed to evaluate the feasibility of Cognitive Therapy (CT) as an intervention for internalised stigma in people with psychosis. We conducted a single-blind randomised controlled pilot trial comparing CT plus treatment as usual (TAU) with TAU only... Read More about Cognitive therapy for internalised stigma in people experiencing psychosis: A pilot randomised controlled trial.

Service users’ experiences of the treatment decision-making process in psychosis: A phenomenological analysis (2016)
Journal Article
Stovell, D., Wearden, A., Morrison, A. P., & Hutton, P. (2016). Service users’ experiences of the treatment decision-making process in psychosis: A phenomenological analysis. Psychosis, 8(4), 311-323. https://doi.org/10.1080/17522439.2016.1145730

Objectives:
We aimed to explore the treatment decision-making experiences of
individuals with psychosis, and their implications for increasing service users autonomy through clinical practice and research.

Design:
A qualitative design was used... Read More about Service users’ experiences of the treatment decision-making process in psychosis: A phenomenological analysis.

In reply to Adams and colleagues (2015)
Journal Article
Hutton, P., Taylor, P. J., & Morrison, A. P. (2015). In reply to Adams and colleagues. Psychosis, 7(4), 367-367. https://doi.org/10.1080/17522439.2015.1093017

Dear Editor

We disagree with the Cochrane Schizophrenia Group’s (CSzG) self-assessment that the problems we identified (Hutton, Wood, Taylor, Irving & Morrison, 2014) in their reviews of popular antipsychotics for schizophrenia are not serious. We... Read More about In reply to Adams and colleagues.

Psychosis, delusions and the “jumping to conclusions” reasoning bias: a systematic review and meta-analysis (2015)
Journal Article
Taylor, P., Dudley, R., Wickham, S., & Hutton, P. (2015). Psychosis, delusions and the “jumping to conclusions” reasoning bias: a systematic review and meta-analysis. Schizophrenia Bulletin, 42(3), 652-665. https://doi.org/10.1093/schbul/sbv150

We did a systematic review and meta-analysis to investigate the magnitude and specificity of the “jumping to conclusions” (JTC) bias in psychosis and delusions. We examined the extent to which people with psychosis, and people with delusions specific... Read More about Psychosis, delusions and the “jumping to conclusions” reasoning bias: a systematic review and meta-analysis.

Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal (2015)
Journal Article
Hutton, P., Taylor, P. J., Mulligan, L., Tully, S., & Moncrieff, J. (2015). Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal. British Journal of Psychiatry, 206(5), 360-370. https://doi.org/10.1192/bjp.bp.114.154377

Background:
Immediate-release (IR) quetiapine has been used to treat schizophrenia since 1997, although all the principal placebo-controlled trials have >50% missing outcome data. New studies with relatively lower rates of participant withdrawal hav... Read More about Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal.

Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire (2015)
Journal Article
Taylor, P. J., Pyle, M., Schwannauer, M., Hutton, P., & Morrison, A. P. (2015). Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire. British Journal of Clinical Psychology, 54(4), 361-377. https://doi.org/10.1111/bjc.12079

Objectives:
Negative beliefs about psychosis and other mental health difficulties may contribute to depression and distress in individuals with these experiences. The Personal Beliefs about Experience Questionnaire (PBEQ) and Personal Beliefs about... Read More about Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire.

Are people at risk of psychosis also at risk of suicide and self-harm? A systematic review and meta-analysis (2014)
Journal Article
Taylor, P. J., Hutton, P., & Wood, L. (2015). Are people at risk of psychosis also at risk of suicide and self-harm? A systematic review and meta-analysis. Psychological Medicine, 45(5), 911-926. https://doi.org/10.1017/S0033291714002074

Suicide and self-harm are prevalent in individuals diagnosed with psychotic disorders. However, less is known about the level of self-injurious thinking and behaviour in those individuals deemed to be at ultra-high risk (UHR) of developing psychosis,... Read More about Are people at risk of psychosis also at risk of suicide and self-harm? A systematic review and meta-analysis.

Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis (2014)
Journal Article
Taylor, P. J., Perry, A., Hutton, P., Seddon, C., & Tan, R. (2015). Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis. Psychosis, 7(3), 276-278. https://doi.org/10.1080/17522439.2014.956785

In the interests of providing patient choice and developing more effective interventions forvpeople struggling with psychosis, it is important that alternative talking therapies arevexplored. Cognitive Analytic Therapy is an integrative therapy which... Read More about Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis.

Cognitive therapy for patients with schizophrenia–Authors' reply (2014)
Journal Article
Morrison, A. P., Dunn, G., Turkington, D., Pyle, M., & Hutton, P. (2014). Cognitive therapy for patients with schizophrenia–Authors' reply. Lancet, 384(9941), 401-402. https://doi.org/10.1016/S0140-6736%2814%2961275-7

Our trial1 was not designed to change clinical practice. It was a preliminary trial, which needs to be followed up by a larger, pragmatic multicentre study. It is important not to overinterpret our data, and we explicitly advised against discontinuat... Read More about Cognitive therapy for patients with schizophrenia–Authors' reply.

Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions (2014)
Journal Article
Taylor, P., Hutton, P., & Dudley, R. (2014). Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions. Systematic Reviews, 3(44), https://doi.org/10.1186/2046-4053-3-44

Background
The tendency to form conclusions based on limited evidence is known as the ‘jumping to conclusions’ (JTC) bias, and has been a much studied phenomena in individuals with psychosis. Previous reviews have supported the hypothesis that a JTC... Read More about Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions.

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial (2014)
Journal Article
Morrison, A. P., Turkington, D., Pyle, M., Spencer, H., Brabban, A., Dunn, G., Christodoulides, T., Dudley, R., Chapman, N., Callcott, P., Grace, T., Lumley, V., Drage, L., Tully, S., Irving, K., Cummings, A., Byrne, R., Davies, L. M., & Hutton, P. (2014). Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial. Lancet, 383(9926), 1395-1403. https://doi.org/10.1016/s0140-6736%2813%2962246-1

BACKGROUND:
Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment. We aimed to establish whether cognitive therapy was effective in reducing psychi... Read More about Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.

Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis (2013)
Journal Article
Hutton, P., Wood, L., Taylor, P. J., Irving, K., & Morrison, A. P. (2014). Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis. Psychosis, 6(3), 220-230. https://doi.org/10.1080/17522439.2013.825005

Background: Cognitive behavioural therapy (CBT) is a recommended treatment for people with psychosis, with meta - analyses showing important benefits when compared to treatment as usual (TAU). However, there has been growing debate as to whether CBT... Read More about Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis.

Antipsychotic Drugs (2013)
Book Chapter
Hutton, P., Weinmann, S., Bola, J. & Read, J. (2013). Antipsychotic Drugs. . In . Models of Madness: Psychological, Social and Biological Approaches to Psychosis. 105-124. (2nd). Taylor & Francis (Routledge). . .

Antipsychotic drugs.

Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis (2013)
Journal Article
Hutton, P. (2013). Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis. Psychology and Psychotherapy: Theory, Research and Practice, 86(2), 139-145. doi:10.1111/papt.12009

Newton-Howes and Wood (published online, this journal, 8 Dec 2011) report the results of their systematic review and meta-analysis of clinical trials of cognitive-behavioural therapy (CBT) for schizophrenia. They ran a random effects analysis of endp... Read More about Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis.

Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis (2013)
Journal Article
Taylor, P. J., Hutton, P., & Taylor, P. J. (2014). Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis. Psychological Medicine, 44(3), 449-468. https://doi.org/10.1017/s0033291713000354

Background.
Clinical equipoise regarding preventative treatments for psychosis has encouraged the development and evaluation of psychosocial treatments, such as cognitive behavioural therapy (CBT).

Method.
A systematic review and meta-analysis w... Read More about Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis.

Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial (2013)
Journal Article
Morrison, A. P., Wardle, M., Hutton, P., Davies, L., Dunn, G., Brabban, A., …Turkington, D. (2013). Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial. Psychosis, 5(1), 82-92. https://doi.org/10.1080/17522439.2012.756539

Aims:
Recent evidence regarding over-estimation of the efficacy of antipsychotics and under-estimation of their toxicity, as well as emerging data regarding alternative treatment options, suggest it may be time to introduce patient choice. However,... Read More about Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial.

Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study (2013)
Journal Article
Hutton, P., Morrison, A. P., Wardle, M., & Wells, A. (2014). Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study. Behavioural and Cognitive Psychotherapy, 42(2), 166-185. https://doi.org/10.1017/S1352465812001026

Background:
More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitiv... Read More about Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study.

Embracing patient choice - Reply (2012)
Journal Article
Morrison, A. P., Hutton, P., Shiers, D., & Turkington, D. (2012). Embracing patient choice - Reply. British Journal of Psychiatry, 201, 494-495

Reply to the article - "Embracing patient choice" - Lobban, F in The British Journal of Psychiatry Dec 2012, 201 (6) 494; DOI: 10.1192/bjp.201.6.494

Collaborative empiricism in cognitive therapy for psychosis: A practice guide (2012)
Journal Article
Hutton, P., & Morrison, A. P. (2013). Collaborative empiricism in cognitive therapy for psychosis: A practice guide. Cognitive and Behavioral Practice, 20(4), 429-444. https://doi.org/10.1016/j.cbpra.2012.08.003

We outline our understanding of collaborative empiricism (CE) as used in cognitive therapy (CT) for psychosis. We discuss how CE can be thought of as a technique for facilitating cognitive change in the service of a client's goals, but also as an exp... Read More about Collaborative empiricism in cognitive therapy for psychosis: A practice guide.

Self-attacking and self-reassurance in persecutory delusions: A comparison of healthy, depressed and paranoid individuals (2012)
Journal Article
Hutton, P., Kelly, J., Lowens, I., Taylor, P. J., & Tai, S. (2013). Self-attacking and self-reassurance in persecutory delusions: A comparison of healthy, depressed and paranoid individuals. Psychiatry Research, 205(1), 127-136. https://doi.org/10.1016/j.psychres.2012.08.010

Previous research has found that reduced self-reassurance and heightened verbal 'self-attacking' of a sadistic and persecutory nature are both associated with greater subclinical paranoia. Whether these processes are also linked to clinical paranoia... Read More about Self-attacking and self-reassurance in persecutory delusions: A comparison of healthy, depressed and paranoid individuals.

Antipsychotics: is it time to introduce patient choice? (2012)
Journal Article
Morrison, A. P., Hutton, P., Shiers, D., & Turkington, D. (2012). Antipsychotics: is it time to introduce patient choice?. British Journal of Psychiatry, 201(2), 83-84. https://doi.org/10.1192/bjp.bp.112.112110

Evidence regarding overestimation of the efficacy of antipsychotics and underestimation of their toxicity, as well as emerging data regarding alternative treatment options, suggests it may be time to introduce patient choice and reconsider whether ev... Read More about Antipsychotics: is it time to introduce patient choice?.

Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics (2012)
Journal Article
Hutton, P., Morrison, A. P., Yung, A. R., Taylor, P. J., French, P., & Dunn, G. (2012). Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics. Acta Psychiatrica Scandinavica, 126(1), 1-11. https://doi.org/10.1111/j.1600-0447.2012.01858.x

Objective:
Our aim was to find out how Cochrane reviews of five popular or frequently prescribed second-generation antipsychotics in the UK (olanzapine, risperidone, quetiapine, amisulpride and aripiprazole) approached the problem of high drop-out i... Read More about Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics.

A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication (2011)
Journal Article
Morrison, A. P., Turkington, D., Wardle, M., Spencer, H., Barratt, S., Dudley, R., …Hutton, P. (2012). A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication. Behaviour Research and Therapy, 50(2), 163-167. https://doi.org/10.1016/j.brat.2011.12.001

BACKGROUND:

Cognitive behaviour therapy (CBT) has been shown to be effective in an open trial for people with psychotic disorders who have not been taking antipsychotic medication. There is little known about predictors of outcome in CBT for psych... Read More about A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication.

Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group (2011)
Journal Article
Hutton, P., Parker, S., Bowe, S., & Ford, S. (2012). Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group. Early Intervention in Psychiatry, 6(1), 91-96. https://doi.org/10.1111/j.1751-7893.2011.00307.x

Background: There is little data available on the prevalence of violence risk factors in people at ultra-high risk of developing psychosis.

Aim: The aim of this study was to provide an estimate of the cross-sectional prevalence of violence risk fa... Read More about Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group.

Prevalence of suicide risk factors in people at ultra-high risk of developing psychosis: a service audit: Suicide risk in UHR clients (2011)
Journal Article
Hutton, P., Bowe, S., Parker, S., & Ford, S. (2011). Prevalence of suicide risk factors in people at ultra-high risk of developing psychosis: a service audit: Suicide risk in UHR clients. Early Intervention in Psychiatry, 5(4), 375-380. https://doi.org/10.1111/j.1751-7893.2011.00302.x

Aim: The aim of this study was to provide an estimate of the cross-sectional prevalence of possible suicide risk factors in those attending a routine clinical service for people at UHR of developing psychosis.

Methods: For all patients in treatmen... Read More about Prevalence of suicide risk factors in people at ultra-high risk of developing psychosis: a service audit: Suicide risk in UHR clients.

Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial (2011)
Journal Article
Morrison, A. P., Hutton, P., Wardle, M., Spencer, H., Barratt, S., Brabban, A., …Turkington, D. (2012). Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial. Psychological Medicine, 42(05), 1049-1056. https://doi.org/10.1017/s0033291711001899

Although antipsychotic medication is the first line of treatment for schizophrenia, many service users choose to refuse or discontinue their pharmacological treatment. Cognitive therapy (CT) has been shown to be effective when delivered in combinatio... Read More about Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial.

Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report (2011)
Journal Article
Hutton, P., Morrison, A. P., & Taylor, H. (2012). Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report. Behavioural and Cognitive Psychotherapy, 40(1), 111-116

Background:
Cognitive behavioural therapy (CBT) can be helpful for many people who experience psychosis; however most research trials have been conducted with people also taking antipsychotic medication. There is little evidence to know whether CBT... Read More about Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report.

Electronic prescribing and prescription design in ophthalmic practice (2011)
Journal Article
Connor, A. J., Hutton, P., Severn, P., & Masri, I. (2011). Electronic prescribing and prescription design in ophthalmic practice. European Journal of Ophthalmology, 21(5), 644-648. https://doi.org/10.5301/EJO.2011.6225

PURPOSE: Prescription and drug errors are common causes of adverse clinical events, posing a significant risk to safe patient care. Although there has been a movement to increase the use of electronic prescribing, concerns over feasibility suggest th... Read More about Electronic prescribing and prescription design in ophthalmic practice.

Provision of online normalising information to reduce stigma associated with psychosis: Can an audio podcast challenge negative appraisals of psychotic experiences? (2010)
Journal Article
French, P., Hutton, P., Barratt, S., Parker, S., Byrne, R., Shryane, N., & Morrison, A. P. (2011). Provision of online normalising information to reduce stigma associated with psychosis: Can an audio podcast challenge negative appraisals of psychotic experiences?. Psychosis, 3(1), 52-62. https://doi.org/10.1080/17522431003717683

Cognitive models of psychosis suggest that challenging negative appraisals of psychotic experiences could directly reduce associated distress and stigma. A pilot study investigating whether online normalising information in the form of an audio podca... Read More about Provision of online normalising information to reduce stigma associated with psychosis: Can an audio podcast challenge negative appraisals of psychotic experiences?.

STEPS: Going beyond the tip of the iceberg. A multi‐level, multipurpose approach to common mental health problems (2008)
Journal Article
White, J., Joice, A., Petrie, S., Johnston, S., Gilroy, D., Hutton, P., & Hynes, N. (2008). STEPS: Going beyond the tip of the iceberg. A multi‐level, multipurpose approach to common mental health problems. Journal of Public Mental Health, 7(1), 42-50. https://doi.org/10.1108/17465729200800007

STEPS is a primary care mental health team that has attempted to develop a very high volume multi‐level, multi‐purpose service for those with mild to moderate problems. The service attempts to overcome many of the limitations of more traditional serv... Read More about STEPS: Going beyond the tip of the iceberg. A multi‐level, multipurpose approach to common mental health problems.