Skip to main content

Research Repository

Advanced Search

Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?

Spencer, Helen M.; McMenamin, Martina; Emsley, Richard; Turkington, Douglas; Dunn, Graham; Morrison, Anthony P.; Brabban, Alison; Hutton, Paul; Dudley, Robert

Authors

Helen M. Spencer

Martina McMenamin

Richard Emsley

Douglas Turkington

Graham Dunn

Anthony P. Morrison

Alison Brabban

Robert Dudley



Abstract

This study investigated the effect of “dose” and the components of Cognitive Behavioral Therapy (CBT) on treatment effects. It is a secondary analysis of the ACTION (Assessment of Cognitive Therapy Instead of Neuroleptics) trial which investigated CBT for people with schizophrenia spectrum disorders that chose not to take antipsychotic medication. Using instrumental variable methods,we found a “dose-response” such that each CBT session attended, reduced the primary outcome measure (the PANSS total score) by approximately 0.6 points (95% CI −1.20 to −0.06, p = 0.031). This suggests that length of therapy is important for those that receive CBT in the absence of antipsychotic medication. Secondly, using principal stratification we examined the process variables that modified treatment effects. Findings revealed that those who received a longitudinal formulation in the first 4 sessions of CBT had poorer treatment effects than those who did not, however this finding was not statistically significant (95% CI −37.244, 6.677, p=0.173). However, it is important to note that these findings were evident in an exploratory analysiswith a small sample. Future larger scale studies are needed to help understand components of effective treatment.

Citation

Spencer, H. M., McMenamin, M., Emsley, R., Turkington, D., Dunn, G., Morrison, A. P., …Dudley, R. (2018). Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?. Schizophrenia Research, 202, 385-386. https://doi.org/10.1016/j.schres.2018.07.016

Journal Article Type Letter
Acceptance Date Jul 3, 2018
Online Publication Date Jul 12, 2018
Publication Date 2018-12
Deposit Date Jul 16, 2018
Publicly Available Date Jul 13, 2019
Journal Schizophrenia Research
Print ISSN 0920-9964
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 202
Pages 385-386
DOI https://doi.org/10.1016/j.schres.2018.07.016
Keywords Biological Psychiatry; Psychiatry and Mental health
Public URL http://researchrepository.napier.ac.uk/Output/1249515

Whoops, looks like something went wrong.