Dr Luke Holman's Outputs (68)

Quantifying the phenome-wide response to sex-specific selection in Drosophila melanogaster (2025)
Journal Article
Keaney, T. A., & Holman, L. (online). Quantifying the phenome-wide response to sex-specific selection in Drosophila melanogaster. Evolution, https://doi.org/10.1093/evolut/qpaf024

In species with separate sexes, selection on males causes evolutionary change in female traits values (and vice versa) via genetic correlations, which has far-reaching consequences for adaptation. Here, we utilise a sex-specific form of Robertson’s S... Read More about Quantifying the phenome-wide response to sex-specific selection in Drosophila melanogaster.

From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology (2024)
Journal Article
Hoedjes, K. M., Grath, S., Posnien, N., Ritchie, M. G., Schlötterer, C., Abbott, J. K., Almudi, I., Coronado‐Zamora, M., Durmaz Mitchell, E., Flatt, T., Fricke, C., Glaser‐Schmitt, A., González, J., Holman, L., Kankare, M., Lenhart, B., Orengo, D. J., Snook, R. R., Yılmaz, V. M., & Yusuf, L. (online). From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology. Molecular Ecology, https://doi.org/10.1111/mec.17382

RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular lev... Read More about From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology.

Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome (2023)
Journal Article
Wong, H. W. S., & Holman, L. (2023). Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome. Evolution, 77(12), 2642–2655. https://doi.org/10.1093/evolut/qpad163

Selection varies between categories of individuals, with far-reaching ramifications: Sex-specific selection can impede or accelerate adaptation, and differences in selection between young and old individuals are ultimately responsible for senescence.... Read More about Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome.

Polygenic signals of sex differences in selection in humans from the UK Biobank (2022)
Journal Article
Ruzicka, F., Holman, L., & Connallon, T. (2022). Polygenic signals of sex differences in selection in humans from the UK Biobank. PLOS Biology, 20(9), Article e3001768. https://doi.org/10.1371/journal.pbio.3001768

Sex differences in the fitness effects of genetic variants can influence the rate of adaptation and the maintenance of genetic variation. For example, “sexually antagonistic” (SA) variants, which are beneficial for one sex and harmful for the other,... Read More about Polygenic signals of sex differences in selection in humans from the UK Biobank.

Experimental sexual selection affects the evolution of physiological and life‐history traits (2022)
Journal Article
Garlovsky, M. D., Holman, L., Brooks, A. L., Novicic, Z. K., & Snook, R. R. (2022). Experimental sexual selection affects the evolution of physiological and life‐history traits. Journal of Evolutionary Biology, 35(5), 742-751. https://doi.org/10.1111/jeb.14003

Sexual selection and sexual conflict are expected to affect all aspects of the phenotype, not only traits that are directly involved in reproduction. Here, we show coordinated evolution of multiple physiological and life-history traits in response to... Read More about Experimental sexual selection affects the evolution of physiological and life‐history traits.

Social immunity in the honey bee: do immune-challenged workers enter enforced or self-imposed exile? (2022)
Journal Article
Conroy, T. E., & Holman, L. (2022). Social immunity in the honey bee: do immune-challenged workers enter enforced or self-imposed exile?. Behavioral Ecology and Sociobiology, 76(2), Article 32. https://doi.org/10.1007/s00265-022-03139-z

Animals living in large colonies are especially vulnerable to infectious pathogens and may therefore have evolved additional defences. Eusocial insects supplement their physiological immune systems with ‘social immunity’, a set of adaptations that im... Read More about Social immunity in the honey bee: do immune-challenged workers enter enforced or self-imposed exile?.

A comment on 'The adaptive value of gluttony: predators mediate the life history trade‐offs of satiation threshold' by Pruitt & Krauel (2010) (2021)
Journal Article
Postma, E., Gonzalez‐Voyer, A., & Holman, L. (2021). A comment on 'The adaptive value of gluttony: predators mediate the life history trade‐offs of satiation threshold' by Pruitt & Krauel (2010). Journal of Evolutionary Biology, 34(12), 1989-1993. https://doi.org/10.1111/jeb.13885

Inspection of the data that accompany Pruitt and Krauel's study of individual variation in satiation threshold and a comparison of these data with the Materials and Methods and Results sections of the paper have revealed a number of issues that cast... Read More about A comment on 'The adaptive value of gluttony: predators mediate the life history trade‐offs of satiation threshold' by Pruitt & Krauel (2010).

Sexual selection affects the evolution of physiological and life history traits (2021)
Preprint / Working Paper
Snook, R. R., Brooks, A. L., Holman, L., & Garlovsky, S. D. Sexual selection affects the evolution of physiological and life history traits

Sexual selection and sexual conflict are expected to affect all aspects of the phenotype, not only traits that are directly involved in reproduction. Here, we show coordinated evolution of multiple physiological and life history traits in response to... Read More about Sexual selection affects the evolution of physiological and life history traits.

Sexual selection can partly explain low frequencies of Segregation Distorter alleles (2021)
Journal Article
Keaney, T. A., Jones, T. M., & Holman, L. (2021). Sexual selection can partly explain low frequencies of Segregation Distorter alleles. Proceedings of the Royal Society B: Biological Sciences, 288(1959), https://doi.org/10.1098/rspb.2021.1190

The Segregation Distorter (SD) allele found in Drosophila melanogaster distorts Mendelian inheritance in heterozygous males by causing developmental failure of non-SD spermatids, such that greater than 90% of the surviving sperm carry SD. This within... Read More about Sexual selection can partly explain low frequencies of Segregation Distorter alleles.

Male‐biased sexual selection, but not sexual dichromatism, predicts speciation in birds (2021)
Journal Article
Cally, J. G., Stuart‐Fox, D., Holman, L., Dale, J., & Medina, I. (2021). Male‐biased sexual selection, but not sexual dichromatism, predicts speciation in birds. Evolution, 75(4), 931-944. https://doi.org/10.1111/evo.14183

Sexual selection is thought to shape phylogenetic diversity by affecting speciation or extinction rates. However, the net effect of sexual selection on diversification is hard to predict because many of the hypothesized effects on speciation or extin... Read More about Male‐biased sexual selection, but not sexual dichromatism, predicts speciation in birds.

Resistance to natural and synthetic gene drive systems (2020)
Journal Article
Price, T. A. R., Windbichler, N., Unckless, R. L., Sutter, A., Runge, J., Ross, P. A., Pomiankowski, A., Nuckolls, N. L., Montchamp‐Moreau, C., Mideo, N., Martin, O. Y., Manser, A., Legros, M., Larracuente, A. M., Holman, L., Godwin, J., Gemmell, N., Courret, C., Buchman, A., Barrett, L. G., & Lindholm, A. K. (2020). Resistance to natural and synthetic gene drive systems. Journal of Evolutionary Biology, 33(10), 1345-1360. https://doi.org/10.1111/jeb.13693

Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease contr... Read More about Resistance to natural and synthetic gene drive systems.

Sibling rivalry versus mother's curse: can kin competition facilitate a response to selection on male mitochondria? (2020)
Journal Article
Keaney, T. A., Wong, H. W. S., Dowling, D. K., Jones, T. M., & Holman, L. (2020). Sibling rivalry versus mother's curse: can kin competition facilitate a response to selection on male mitochondria?. Proceedings of the Royal Society B: Biological Sciences, 287(1930), https://doi.org/10.1098/rspb.2020.0575

Assuming that fathers never transmit mitochondrial DNA (mtDNA) to their offspring, mitochondrial mutations that affect male fitness are invisible to direct selection on males, leading to an accumulation of male-harming alleles in the mitochondrial ge... Read More about Sibling rivalry versus mother's curse: can kin competition facilitate a response to selection on male mitochondria?.

An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura (2019)
Journal Article
Larner, W., Price, T., Holman, L., & Wedell, N. (2019). An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura. Proceedings of the Royal Society B: Biological Sciences, 286(1916), Article 20192038. https://doi.org/10.1098/rspb.2019.2038

Selfish ‘meiotic drive’ alleles are transmitted to more than 50% of offspring, allowing them to rapidly invade populations even if they reduce the fitness of individuals carrying them. Theory predicts that drivers should either fix or go extinct, yet... Read More about An X-linked meiotic drive allele has strong, recessive fitness costs in female Drosophila pseudoobscura.

Mother’s curse and indirect genetic effects: Do males matter to mitochondrial genome evolution? (2019)
Journal Article
Keaney, T. A., Wong, H. W. S., Dowling, D. K., Jones, T. M., & Holman, L. (2020). Mother’s curse and indirect genetic effects: Do males matter to mitochondrial genome evolution?. Journal of Evolutionary Biology, 33(2), 189-201. https://doi.org/10.1111/jeb.13561

Maternal inheritance of mitochondrial DNA (mtDNA) was originally thought to prevent any response to selection on male phenotypic variation attributable to mtDNA, resulting in a male‐biased mtDNA mutation load (“mother's curse”). However, the theory u... Read More about Mother’s curse and indirect genetic effects: Do males matter to mitochondrial genome evolution?.

Fitness consequences of the selfish supergene Segregation Distorter (2019)
Journal Article
Wong, H. W. S., & Holman, L. (2020). Fitness consequences of the selfish supergene Segregation Distorter. Journal of Evolutionary Biology, 33(1), 89-100. https://doi.org/10.1111/jeb.13549

Segregation distorters are selfish genetic elements that subvert Mendelian inheritance, often by destroying gametes that do not carry the distorter. Simple theoretical models predict that distorter alleles will either spread to fixation or stabilize... Read More about Fitness consequences of the selfish supergene Segregation Distorter.

Evolutionary simulations of Z-linked suppression gene drives (2019)
Journal Article
Holman, L. (2019). Evolutionary simulations of Z-linked suppression gene drives. Proceedings of the Royal Society B: Biological Sciences, 286(1912), Article 20191070. https://doi.org/10.1098/rspb.2019.1070

Synthetic gene drives may soon be used to suppress or eliminate populations of disease vectors, pathogens, invasive species, and agricultural pests. Recent proposals have focused on using Z-linked gene drives to control species with ZW sex determinat... Read More about Evolutionary simulations of Z-linked suppression gene drives.

Meta-analytic evidence that sexual selection improves population fitness (2019)
Journal Article
Cally, J. G., Stuart-Fox, D., & Holman, L. (2019). Meta-analytic evidence that sexual selection improves population fitness. Nature Communications, 10, Article 2017 (2019). https://doi.org/10.1038/s41467-019-10074-7

Sexual selection has manifold ecological and evolutionary consequences, making its net effect on population fitness difficult to predict. A powerful empirical test is to experimentally manipulate sexual selection and then determine how population fit... Read More about Meta-analytic evidence that sexual selection improves population fitness.

Researchers collaborate with same-gendered colleagues more often than expected across the life sciences (2019)
Journal Article
Holman, L., & Morandin, C. (2019). Researchers collaborate with same-gendered colleagues more often than expected across the life sciences. PLOS ONE, 14(4), Article e0216128. https://doi.org/10.1371/journal.pone.0216128

Evidence suggests that women in academia are hindered by conscious and unconscious biases, and often feel excluded from formal and informal opportunities for research collaboration. In addition to ensuring fairness and helping to redress gender imbal... Read More about Researchers collaborate with same-gendered colleagues more often than expected across the life sciences.

Comparative transcriptomics of social insect queen pheromones (2019)
Journal Article
Holman, L., Helanterä, H., Trontti, K., & Mikheyev, A. S. (2019). Comparative transcriptomics of social insect queen pheromones. Nature Communications, 10, Article 1593 (2019). https://doi.org/10.1038/s41467-019-09567-2

Queen pheromones are chemical signals that mediate reproductive division of labor in eusocial animals. Remarkably, queen pheromones are composed of identical or chemically similar compounds in some ants, wasps and bees, even though these taxa diverge... Read More about Comparative transcriptomics of social insect queen pheromones.

Evolution of female choice under intralocus sexual conflict and genotype-by-environment interactions (2018)
Journal Article
Li, X.-Y., & Holman, L. (2018). Evolution of female choice under intralocus sexual conflict and genotype-by-environment interactions. Philosophical Transactions B: Biological Sciences, 373(1757), 20170425. https://doi.org/10.1098/rstb.2017.0425

In many species, females are hypothesized to obtain ‘good genes’ for their offspring by mating with males in good condition. However, female preferences might deplete genetic variance and make choice redundant. Additionally, high-condition males some... Read More about Evolution of female choice under intralocus sexual conflict and genotype-by-environment interactions.