Dr Janis MacCallum's Outputs (26)

Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers (1998)
Journal Article
Phillips, H., MacCallum, J., Burns, D., Cho-Chung, Y., & Miller, W. (1998). Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers. The Breast, 7(3), 139-142. https://doi.org/10.1016/s0960-9776%2898%2990024-8

There is evidence that the regulatory subunits (R) of cyclic AMP-dependent protein kinase A (PKA) are important in the biology of breast cancer and that mutations of both RIα and RIIβ, alter cellular behaviour. Consequently, a PCR-SSCP assay was esta... Read More about Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers.

Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues (1997)
Journal Article
MacCallum, J., Cummings, J., Dixon, J., & Miller, W. (1997). Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues. Journal of Chromatography B, 698(1-2), 269-275. https://doi.org/10.1016/S0378-4347%2897%2900286-7

A sensitive (200 ng/g) and selective reversed-phase high-performance liquid chromatography separation has been developed to determine the levels of tamoxifen, 4-hydroxytamoxifen (4-OH) and desmethyltamoxifen (DMT) in tumour tissue taken from patients... Read More about Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues.

Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy (1996)
Journal Article
MacCallum, J., Keen, J., Bartlett, J., Thompson, A., Dixon, J., & Miller, W. (1996). Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy. British Journal of Cancer, 74(3), 474-478. https://doi.org/10.1038/bjc.1996.385

Tumour was obtained from 37 patients with oestrogen receptor-positive breast cancer, before and during treatment with tamoxifen, and examined qualitatively and semi-qualitatively for mRNA of the three mammalian TGF-beta isoforms. Levels of TGF-beta i... Read More about Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy.

Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma (1996)
Journal Article
MacCallum, J., Cummings, J., Dixon, J., & Miller, W. (1996). Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma. Journal of Chromatography B, 678(2), 317-323. https://doi.org/10.1016/0378-4347%2895%2900530-7

Tamoxifen (TAM) is a triphenylethylene anti-oestrogen, commonly used in the treatment of breast cancer. Patients receiving tamoxifen therapy may experience both de novo and acquired resistance. As one of the mechanisms for this may be extensive perip... Read More about Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma.

Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization (1995)
Journal Article
MacCallum, J., Poulsom, R., Hanby, A., & Miller, W. (1995). Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization. The Breast, 4(4), 289-296. https://doi.org/10.1016/s0960-9776%2895%2980006-9

As transforming growth factor betas (TGFβs) are of potential importance in the natural history of breast cancer, it is desirable to develop assays which allow detection of the isoforms of TGFβ, at the level of mRNA and protein in clinical material. I... Read More about Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization.

Expression of transforming growth factor beta mRNA isoforms in human breast cancer (1994)
Journal Article
MacCallum, J., Bartlett, J., Thompson, A., Keen, J., Dixon, J., & Miller, W. (1994). Expression of transforming growth factor beta mRNA isoforms in human breast cancer. British Journal of Cancer, 69(6), 1006-1009. https://doi.org/10.1038/bjc.1994.197

Using an RNAse protection assay, expression of messenger RNA for isoforms of TGF-beta was determined in a series of breast cancers. Of 50 tumours, 45 (90%) expressed TGF-beta 1 mRNA, 39 (78%) expressed TGF-beta 2, and 47 (94%) expressed TGF-beta 3. P... Read More about Expression of transforming growth factor beta mRNA isoforms in human breast cancer.