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Dr Alpana Mair's Outputs (52)

Addressing the Challenge of Polypharmacy (2019)
Journal Article
Mair, A., Wilson, M., & Dreischulte, T. (2020). Addressing the Challenge of Polypharmacy. Annual Review of Pharmacology and Toxicology, 60(1), 661-681. https://doi.org/10.1146/annurev-pharmtox-010919-023508

Polypharmacy describes the concomitant use of multiple medicines and represents a growing global challenge attributable to aging populations with an increasing prevalence of multimorbidity. Polypharmacy can be appropriate but is problematic when the... Read More about Addressing the Challenge of Polypharmacy.

Polypharmacy and Integrated Care (2021)
Book Chapter
Mair, A., & Alonso, A. (2021). Polypharmacy and Integrated Care. In V. Amelung, V. Stein, E. Suter, N. Goodwin, E. Nolte, & R. Balicer (Eds.), Handbook Integrated Care (453-477). Springer. https://doi.org/10.1007/978-3-030-69262-9_27

Safe and effective pharmacological treatment remains one of the greatest challenges in medicine, where models of healthcare delivery lag behind the enormous growth in single disease focused treatment with medicines. The implications for safe, efficie... Read More about Polypharmacy and Integrated Care.

Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials (2020)
Journal Article
Pazan, F., Petrovic, M., Cherubini, A., Onder, G., Cruz-Jentoft, A. J., Denkinger, M., van der Cammen, T. J. M., Stevenson, J. M., Ibrahim, K., Rajkumar, C., Bakken, M. S., Baeyens, J.-P., Crome, P., Frühwald, T., Gallaghar, P., Guðmundsson, A., Knol, W., O’Mahony, D., Pilotto, A., Rönnemaa, E., …Wehling, M. (2021). Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials. European Journal of Clinical Pharmacology, 77(1), 1-12. https://doi.org/10.1007/s00228-020-02951-8

Background
Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty.

Methods
A literatur... Read More about Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials.

The polypharmacy programme in Scotland: realistic prescribing (2019)
Journal Article
Mair, A., Wilson, M., & Dreischulte, T. (2019). The polypharmacy programme in Scotland: realistic prescribing. Prescriber, 30(8), 10-16. https://doi.org/10.1002/psb.1779

Since 2012, NHS Scotland has published a series of polypharmacy guidelines to help clinicians address the many medication‐related problems arising from multimorbidity. Here, Alpana Mair, Chair of the guideline group, Martin Wilson and Tobias Dreischu... Read More about The polypharmacy programme in Scotland: realistic prescribing.

Quality prescribing for Benzodiazepines and z-drugs: guide for improvement 2024 to 2027 (2024)
Report
Cook, A., Mair, A., Smith, G., & Strath, A. (2024). Quality prescribing for Benzodiazepines and z-drugs: guide for improvement 2024 to 2027

Benzodiazepines and z-drugs are indicated for a variety of conditions including the short-term relief of severe insomnia and some anxiety disorders. People can quickly become tolerant to the therapeutic effects of benzodiazepines and z-drugs, renderi... Read More about Quality prescribing for Benzodiazepines and z-drugs: guide for improvement 2024 to 2027.

Safe Prescribing and Monitoring in the Older Person (2024)
Book Chapter
Mair, A. R., Mair, A. R., Hilmer, S., & Kouladjian O’Donnell, L. (2024). Safe Prescribing and Monitoring in the Older Person. In J. Jose, A. R. Cox, & V. Paudyal (Eds.), Principles and Practice of Pharmacovigilance and Drug Safety (459-482). Springer. https://doi.org/10.1007/978-3-031-51089-2_20

This chapter will consider the main factors that increase the risk of adverse drug reactions and events in older people. This will include changes in physiology that affect the older person. It will also outline how older people should be prioritized... Read More about Safe Prescribing and Monitoring in the Older Person.

Polypharmacy and Deprescribing (2024)
Book Chapter
Mair, A. R., Jordon, M., & Mullan, J. (2024). Polypharmacy and Deprescribing. In J. Jose, A. R. Cox, & V. Paudyal (Eds.), Principles and Practice of Pharmacovigilance and Drug Safety (405-435). Springer. https://doi.org/10.1007/978-3-031-51089-2_18

Polypharmacy contributes to medication-related harm. Medication-related harm accounts for approximately 9% of hospital admissions worldwide, and it is estimated that many of these hospitalisations are preventable. It is therefore important to conside... Read More about Polypharmacy and Deprescribing.

Quality prescribing for antidepressants: guide for improvement 2024 to 2027 (2024)
Report
Cook, A., Mair, A., Smith, G., & Strath, A. (2024). Quality prescribing for antidepressants: guide for improvement 2024 to 2027

The prescribing of antidepressants continues to increase in Scotland, with many people receiving antidepressants for two years or more. This may be appropriate for some individuals, but it is important that ongoing treatment is reviewed regularly and... Read More about Quality prescribing for antidepressants: guide for improvement 2024 to 2027.

Type 2 Diabetes Mellitus - quality prescribing strategy: improvement guide 2024 to 2027 (2024)
Report
Mair, A., Kennon, B., Chalmers, J., Smith, G., Strath, A., McMahon, A., & Leitch, J. (2024). Type 2 Diabetes Mellitus - quality prescribing strategy: improvement guide 2024 to 2027. Scottish Government

This quality prescribing guide is intended to support clinicians across the multidisciplinary team and people with Type 2 Diabetes Mellitus (T2DM) in shared decision-making and the effective use of medicines, and offers practical advice and options f... Read More about Type 2 Diabetes Mellitus - quality prescribing strategy: improvement guide 2024 to 2027.

Proceedings of the International Ambulatory Drug Safety Symposium: Munich, Germany, June 2023 (2023)
Journal Article
Alexander, G. C., Budnitz, D., Hughes, C., Maas, R., Mair, A., McDonald, E. G., Meid, A. D., Payne, R., Seidling, H. M., Shakir, S., Suissa, S., Tannenbaum, C., Schneeweiss, S., & Dreischulte, T. (2024). Proceedings of the International Ambulatory Drug Safety Symposium: Munich, Germany, June 2023. Drug Safety, 47(1), 103-111. https://doi.org/10.1007/s40264-023-01362-9

Meeting report.

Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application (2023)
Journal Article
Kardas, P., Mair, A., Stewart, D., & Lewek, P. (2023). Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application. Frontiers in Pharmacology, 14, Article 1254912. https://doi.org/10.3389/fphar.2023.1254912

Background: Polypharmacy, defined as the simultaneous use of multiple medications by a patient, is a worldwide problem of rising prevalence. Paving the way for drug interactions, adverse drug reactions and non-adherence, it leads to negative health o... Read More about Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application.

Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper (2023)
Journal Article
van Poelgeest, E., Seppala, L., Bahat, G., Ilhan, B., Mair, A., van Marum, R., Onder, G., Ryg, J., Fernandes, M. A., Cherubini, A., Denkinger, M., Eidam, A., Egberts, A., Gudmundsson, A., Koçak, F. Ö. K., Soulis, G., Tournoy, J., Masud, T., Wehling, M., & van der Velde, N. (2023). Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper. European Geriatric Medicine, 14(6), 1195-1209. https://doi.org/10.1007/s41999-023-00872-0

Key summary points: Aim: To summarize the literature on medication review and deprescribing in older adults, and formulate recommendations to improve prescribing medications in older, multimorbid adults with polypharmacy. Findings: Current evidence d... Read More about Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper.

iSIMPATHY Evaluation Report (2023)
Book
Mair, A., Kirke, C., Scott, M., Michael, N., Kanan, Y., Law, S., Scullin, C., Fleming, G., Hyder Skinner, N., & Kyle, D. (2023). iSIMPATHY Evaluation Report

Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes (2023)
Journal Article
Urbańczyk, K., Guntschnig, S., Antoniadis, V., Falamic, S., Kovacevic, T., Kurczewska-Michalak, M., Miljković, B., Olearova, A., Sviestina, I., Szucs, A., Tachkov, K., Tiszai, Z., Volmer, D., Wiela-Hojeńska, A., Fialova, D., Vlcek, J., Stuhec, M., Hogg, A., Scott, M., Stewart, D., …Kardas, P. (2023). Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes. Frontiers in Pharmacology, 14, Article 1244151. https://doi.org/10.3389/fphar.2023.1244151

Clinical pharmacy as an area of practice, education and research started developing around the 1960s when pharmacists across the globe gradually identified the need to focus more on ensuring the appropriate use of medicines to improve patient outcome... Read More about Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes.