Skip to main content

Research Repository

Advanced Search

Outputs (40)

Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application (2023)
Journal Article
Kardas, P., Mair, A., Stewart, D., & Lewek, P. (2023). Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application. Frontiers in Pharmacology, 14, Article 1254912. https://doi.org/10.3389/fphar.2023.1254912

Background: Polypharmacy, defined as the simultaneous use of multiple medications by a patient, is a worldwide problem of rising prevalence. Paving the way for drug interactions, adverse drug reactions and non-adherence, it leads to negative health o... Read More about Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application.

Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper (2023)
Journal Article
van Poelgeest, E., Seppala, L., Bahat, G., Ilhan, B., Mair, A., van Marum, R., …van der Velde, N. (2023). Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper. European Geriatric Medicine, 14(6), 1195-1209. https://doi.org/10.1007/s41999-023-00872-0

Key summary points: Aim: To summarize the literature on medication review and deprescribing in older adults, and formulate recommendations to improve prescribing medications in older, multimorbid adults with polypharmacy. Findings: Current evidence d... Read More about Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper.

Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes (2023)
Journal Article
Urbańczyk, K., Guntschnig, S., Antoniadis, V., Falamic, S., Kovacevic, T., Kurczewska-Michalak, M., …Kardas, P. (2023). Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes. Frontiers in Pharmacology, 14, Article 1244151. https://doi.org/10.3389/fphar.2023.1244151

Clinical pharmacy as an area of practice, education and research started developing around the 1960s when pharmacists across the globe gradually identified the need to focus more on ensuring the appropriate use of medicines to improve patient outcome... Read More about Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes.

Polypharmacy and Integrated Care (2021)
Book Chapter
Mair, A., & Alonso, A. (2021). Polypharmacy and Integrated Care. In V. Amelung, V. Stein, E. Suter, N. Goodwin, E. Nolte, & R. Balicer (Eds.), Handbook Integrated Care (453-477). Cham: Springer. https://doi.org/10.1007/978-3-030-69262-9_27

Safe and effective pharmacological treatment remains one of the greatest challenges in medicine, where models of healthcare delivery lag behind the enormous growth in single disease focused treatment with medicines. The implications for safe, efficie... Read More about Polypharmacy and Integrated Care.

Appropriate polypharmacy: a barometer for integrated care (2020)
Journal Article
Mair, A., Antoniadou, E., Hendry, A., & Gabrovec, B. (2021). Appropriate polypharmacy: a barometer for integrated care. Journal of Integrated Care, 29(2), 204-214. https://doi.org/10.1108/jica-04-2020-0019

Purpose Polypharmacy, the concurrent use of multiple medicines by one individual, is a common and growing challenge driven by an ageing population and the growing number of people living longer with chronic conditions. Up to 11% of unplanned hospita... Read More about Appropriate polypharmacy: a barometer for integrated care.

Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials (2020)
Journal Article
Pazan, F., Petrovic, M., Cherubini, A., Onder, G., Cruz-Jentoft, A. J., Denkinger, M., …Wehling, M. (2021). Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials. European Journal of Clinical Pharmacology, 77(1), 1-12. https://doi.org/10.1007/s00228-020-02951-8

Background Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty. Methods A literatur... Read More about Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials.

Addressing the Challenge of Polypharmacy (2019)
Journal Article
Mair, A., Wilson, M., & Dreischulte, T. (2020). Addressing the Challenge of Polypharmacy. Annual Review of Pharmacology and Toxicology, 60(1), 661-681. https://doi.org/10.1146/annurev-pharmtox-010919-023508

Polypharmacy describes the concomitant use of multiple medicines and represents a growing global challenge attributable to aging populations with an increasing prevalence of multimorbidity. Polypharmacy can be appropriate but is problematic when the... Read More about Addressing the Challenge of Polypharmacy.

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases (2019)
Journal Article
Bousquet, J. J., the ARIA Study Group, Schünemann, H. J., Togias, A., Erhola, M., Hellings, P. W., …the MASK Study Group. (2019). Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases. Clinical and Translational Allergy, 9, Article 44 (2019). https://doi.org/10.1186/s13601-019-0279-2

Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the healt... Read More about Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases.

The polypharmacy programme in Scotland: realistic prescribing (2019)
Journal Article
Mair, A., Wilson, M., & Dreischulte, T. (2019). The polypharmacy programme in Scotland: realistic prescribing. Prescriber, 30(8), 10-16. https://doi.org/10.1002/psb.1779

Since 2012, NHS Scotland has published a series of polypharmacy guidelines to help clinicians address the many medication‐related problems arising from multimorbidity. Here, Alpana Mair, Chair of the guideline group, Martin Wilson and Tobias Dreischu... Read More about The polypharmacy programme in Scotland: realistic prescribing.

Medication Safety in Transitions of Care: Technical Report (2019)
Report
World Health Organisation. (2019). Medication Safety in Transitions of Care: Technical Report. Geneva: WHO

Medication discrepancies impact almost every patient that moves across transitions of care, e.g. admission to or discharge from hospital. WHO urges countries to prioritise early and sustained action to reduce medication-related harm arising at transi... Read More about Medication Safety in Transitions of Care: Technical Report.

Polypharmacy and pharmacovigilance: How they relate and why it matters (2019)
Journal Article
Mair, A. (2019). Polypharmacy and pharmacovigilance: How they relate and why it matters. Uppsala Reports, 80, 12-13

Patients with multiple medical conditions – and, consequently, needing multiple medications – present one of the greatest challenges currently facing health services.

ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé), 
POLLAR (Impact of Air POLLution on Asthma and Rhinitis), 
GARD Demonstration project (2019)
Journal Article
Bosnic‐Anticevich, S., Costa, E., Menditto, E., Lourenço, O., Novellino, E., Bialek, S., …Bousquet, J. (2019). ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé), 
POLLAR (Impact of Air POLLution on Asthma and Rhinitis), 
GARD Demonstration project. Allergy, 74(7), 1219-1236. https://doi.org/10.1111/all.13701

Pharmacists are trusted health care professionals. Many patients use over‐the‐counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in in... Read More about ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé), 
POLLAR (Impact of Air POLLution on Asthma and Rhinitis), 
GARD Demonstration project.

Age-Related Medicine (2019)
Journal Article
Wahlich, J., Orlu, M., Mair, A., Stegemann, S., & van Riet-Nales, D. (2019). Age-Related Medicine. Pharmaceutics, 11(4), Article 172. https://doi.org/10.3390/pharmaceutics11040172

A meeting organised by the Academy of Pharmaceutical Sciences focussed on the challenges of developing medicines for older adults. International experts discussed the complexity introduced by polypharmacy and multiple morbidities and how the risk–ben... Read More about Age-Related Medicine.

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study (2019)
Journal Article
Sheikh, A., De Vries, G., Anto, J. M., Annesi‐Maesano, I., Wickman, M., Hellings, P. W., …Menditto, E. (2019). Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. Clinical and Experimental Allergy, 49(4), 442-460. https://doi.org/10.1111/cea.13333

Background Mobile technology may help to better understand the adherence to treatment. MASK‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is a... Read More about Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study.

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research (2019)
Journal Article
Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., …the EuGMS Special Interest Group on Pharmacology. (2019). EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research. Drugs and Aging, 36(4), 299-307. https://doi.org/10.1007/s40266-018-0622-7

Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role o... Read More about EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology (2018)
Journal Article
Bousquet, J., Hellings, P. W., Agache, I., Amat, F., Annesi-Maesano, I., Mair, A., & Mobile Airways Sentinel Network (MASK) Study Group, . (2019). Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. Journal of Allergy and Clinical Immunology, 143(3), 864-879. https://doi.org/10.1016/j.jaci.2018.08.049

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase o... Read More about Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology.

A case study of polypharmacy management in nine European countries: Implications for change management and implementation (2018)
Journal Article
McIntosh, J., Alonso, A., MacLure, K., Stewart, D., Kempen, T., Mair, A., …on behalf of the SIMPATHY Consortium. (2018). A case study of polypharmacy management in nine European countries: Implications for change management and implementation. PLOS ONE, 13(4), Article e0195232. https://doi.org/10.1371/journal.pone.0195232

Background Multimorbidity and its associated polypharmacy contribute to an increase in adverse drug events, hospitalizations, and healthcare spending. This study aimed to address: what exists regarding polypharmacy management in the European Union (... Read More about A case study of polypharmacy management in nine European countries: Implications for change management and implementation.

A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people (2017)
Journal Article
Stewart, D., Gibson-Smith, K., MacLure, K., Mair, A., Alonso, A., Codina, C., …Wiese, B. (2017). A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. PLOS ONE, 12(11), Article e0188348. https://doi.org/10.1371/journal.pone.0188348

Background Inappropriate use of multiple medicines (inappropriate polypharmacy) is a major challenge in older people with consequences of increased prevalence and severity of adverse drug reactions and interactions, and reduced medicines adherence.... Read More about A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people.

Medication review and polypharmacy management in the hospital setting. The cases of Greece and Catalonia (2017)
Journal Article
Gennimata, D., Kampolis, C. F., Vontetsianos, T., Mcintosh, J., Codina, C., Alonso, A., & Mair, A. (2017). Medication review and polypharmacy management in the hospital setting. The cases of Greece and Catalonia. International journal of integrated care, 17(5), Article A550. https://doi.org/10.5334/ijic.3870

Introduction: Medication review and polypharmacy management, especially in the elderly, are key components of integrated care. Although polypharmacy management is often associated with the primary care setting, hospital clinicians, who are often memb... Read More about Medication review and polypharmacy management in the hospital setting. The cases of Greece and Catalonia.

Sustainable Implementation of Polypharmacy reviews as part of integrated care at Scale (2017)
Journal Article
Mair, A. R., Kinnear, M., Hurding, S., Micheal, N., & Wilson, M. (2017). Sustainable Implementation of Polypharmacy reviews as part of integrated care at Scale. International journal of integrated care, 17(5), Article A485. https://doi.org/10.5334/ijic.3805

Medication is the most common form of intervention to prevent disease or slow disease progression, with guidelines for single diseases recommending evidence based drug treatments. There remains the mismatch between prescribing guidelines for speci... Read More about Sustainable Implementation of Polypharmacy reviews as part of integrated care at Scale.

Increasing adherence in therapies and polypharmacy in Europe: EIP on AHA Action Group A1 activities toward integrated care information systems and self-management applications (2016)
Journal Article
Fico, G., Cena, C., Mair, A., Monaco, A., Costa, E., Giardini, A., & Papadopoulos, H. (2016). Increasing adherence in therapies and polypharmacy in Europe: EIP on AHA Action Group A1 activities toward integrated care information systems and self-management applications. Digital Medicine, 2(4), 144-148. https://doi.org/10.4103/digm.digm_1_17

No abstract available.

Polypharmacy and Adherence: Key Components of Integrated Care Findings from the SIMPATHY Project (2016)
Journal Article
Mair, A., McIntosh, J., Codina, C., Molist, N., & Alonso, A. (2016). Polypharmacy and Adherence: Key Components of Integrated Care Findings from the SIMPATHY Project. International journal of integrated care, 16(6), A190. https://doi.org/10.5334/ijic.2738

Context, aims and objectives: As many as half of all patients with chronic conditions are using their medicines in a way that is not fully effective, resulting in sub-optimal treatment and subsequent increases in hospitalisations and emergency depart... Read More about Polypharmacy and Adherence: Key Components of Integrated Care Findings from the SIMPATHY Project.

The use of PESTEL as a change management tool to inform change management of polypharmacy and adherence within SIMPATHY program (2016)
Journal Article
Geitona, M., Vontetsianos, T., Mair, A., Mc Kenzie, D., Michael, N., Kousoulakou, H., …Balasopoulou, A. (2016). The use of PESTEL as a change management tool to inform change management of polypharmacy and adherence within SIMPATHY program. International journal of integrated care, 16(6), A52. https://doi.org/10.5334/ijic.2995

Introduction: Polypharmacy and medication adherence in the older populationwith multiple chronic conditionsare significant public health issues across all the European Union (EU) countries. SIMPATHY (Stimulating Innovation Management of Polypharmacy... Read More about The use of PESTEL as a change management tool to inform change management of polypharmacy and adherence within SIMPATHY program.

Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments (2016)
Journal Article
Lewek, P., MacLure, K., McIntosh, J., Alonso, A., Kardas, P., Wilson, M., …Stewart, D. (2016). Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments. Expert Opinion on Drug Safety, 16(2), 203-213. https://doi.org/10.1080/14740338.2017.1265503

Introduction: Single disease state led evidence-based guidelines do not provide sufficient coverage of issues of multimorbidities, with the cumulative impact of recommendations often resulting in overwhelming medicines burden. Inappropriate polypharm... Read More about Guidance to manage inappropriate polypharmacy in older people: systematic review and future developments.

Polypharmacy management: an under recognized public health issue (2016)
Journal Article
McIntosh, J., Alonso, A., Codina, C., & Mair, A. (2016). Polypharmacy management: an under recognized public health issue. European Journal of Public Health, 26(suppl_1), https://doi.org/10.1093/eurpub/ckw174.050

Background Multiple chronic diseases in individuals increase the risk of inappropriate polypharmacy, an under recognised public health issue. SIMPATHY (Stimulating Innovation Management of Polypharmacy and Adherence in The Elderly) aims to develop c... Read More about Polypharmacy management: an under recognized public health issue.

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (2016)
Journal Article
Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E. H., Bewick, M., …Mercier, J. (2016). Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clinical and Translational Allergy, 6, Article 29 (2016). https://doi.org/10.1186/s13601-016-0116-9

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respir... Read More about Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

Prescription For Excellence (2013)
Report
Scottish Government. (2013). Prescription For Excellence. Edinburgh: Scottish Government

Policy document setting out the vision for pharmacy. A vision and action plan for the future of NHS pharmaceutical care in Scotland through integrated partnerships and innovation.

Prescribing and Safety Monitoring in Elderly Care
Book Chapter
Mair, A., Mair, A., Hilmer, S., & Kouladjian O’Donnell, L. (in press). Prescribing and Safety Monitoring in Elderly Care. In Pharmacovigilance and Drug Safety in Clinical Practice. Springer

Cochrane EPOC Protocol Providing medication adherence feedback to healthcare providers. The effect on care and outcomes. Protocol for a Cochrane review update Authors
Working Paper
Hassett, R., Sabatier, B., Savoldelli, V., Mair, A., Hanley, J., Dima, A., & Paterson, R. (2022). Cochrane EPOC Protocol Providing medication adherence feedback to healthcare providers. The effect on care and outcomes. Protocol for a Cochrane review update Authors

This is a protocol for a Cochrane Review (update). Background Key barriers to effectively supporting adherence include poor awareness amongst healthcare professionals (HCPs), scarce clinical tools and interventions, and suboptimal patient-provide... Read More about Cochrane EPOC Protocol Providing medication adherence feedback to healthcare providers. The effect on care and outcomes. Protocol for a Cochrane review update Authors.