Skip to main content

Research Repository

Advanced Search

Prof Nick Wheelhouse's Outputs (91)

The role of infection in miscarriage (2015)
Journal Article
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E., & Horne, A. W. (2016). The role of infection in miscarriage. Human Reproduction Update, 22(1), 116-133. https://doi.org/10.1093/humupd/dmv041

BACKGROUND: Miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. Miscarriage occurs in one in five pregnancies and can have considerable physiological and psych... Read More about The role of infection in miscarriage.

Evidence of members of the Chlamydiales in bovine abortions in England and Wales (2015)
Journal Article
Wheelhouse, N., Mearns, R., Willoughby, K., Wright, E., Turnbull, D., & Longbottom, D. (2015). Evidence of members of the Chlamydiales in bovine abortions in England and Wales. Veterinary Record, 176, 465. https://doi.org/10.1136/vr.103075

Despite the economical importance and welfare issues associated with bovine abortion, as well as the potential zoonotic implications, the rate of diagnosis remains low with a cause of abortion only identified in around 22.5 per cent of submissions re... Read More about Evidence of members of the Chlamydiales in bovine abortions in England and Wales.

Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission (2015)
Journal Article
Wheelhouse, N., & Longbottom, D. (2015). Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission. Current Clinical Microbiology Reports, 2(1), 1-9. https://doi.org/10.1007/s40588-014-0011-x

The chlamydiae are a diverse group of obligate intracellular Gram-negative bacteria that are known to infect a wide variety of host species and are responsible for a wide range of diseases in animals and man. Studies of human disease first provided e... Read More about Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission.

An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius) (2014)
Journal Article
Cope, I., Wheelhouse, N., Pocknell, A., Dagleish, M., & Summers, B. (2014). An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius). Veterinary record case reports, 2(1), Article e000086. https://doi.org/10.1136/vetreccr-2014-000086

Chlamydia species are a relatively newly recognised and emerging pathogen in reptile species. Chlamydia pneumoniae has been reported to cause infections in several snake species, as well as other reptiles and amphibia, leading to granulomatous lesion... Read More about An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius).

Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response (2014)
Journal Article
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., Rae, M. T., & Longbottom, D. (2014). Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLOS ONE, 9(7), Article e102386. https://doi.org/10.1371/journal.pone.0102386

BACKGROUND

Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome... Read More about Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response.

Chlamydia in cases of bovine abortion in Ireland (2014)
Journal Article
Wheelhouse, N., Longbottom, D., & O'Donovan, J. (2014). Chlamydia in cases of bovine abortion in Ireland. Veterinary Record, 174(22), 560-561. https://doi.org/10.1136/vr.g3567

We report the findings of a preliminary investigation into chlamydial involvement in cases of bovine abortion in Ireland. Chlamydia abortus has long been recognised as a known major cause of ruminant abortion. However, several newly recognised specie... Read More about Chlamydia in cases of bovine abortion in Ireland.

Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma (2014)
Journal Article
Tan, B. H. L., Skipworth, R. J. E., Wheelhouse, N. M., Fearon, K. C. H., & Ross, J. A. (2014). Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma. Journal of Cancer Research and Therapeutics, 10(1), 176-179. https://doi.org/10.4103/0973-1482.131458

INTRODUCTION: Both inflammation and mitochondrial DNA (mtDNA) mutation are thought to play a role in the many human cancers. The aim of this study was to evaluate the relationship between inflammation and accumulation of mitochondrial DNA (mtDNA) mut... Read More about Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma.

Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain. (2014)
Journal Article
Sa, R. C. C., Cunningham, A. A., Dagleish, M. P., Wheelhouse, N., Pocknell, A., Borel, N., Peck, H. L., & Lawson, B. (2014). Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain. European journal of wildlife research, 60(2), 395-398. https://doi.org/10.1007/s10344-013-0792-x

The ring-necked parakeet (RNP), Psittacula krameri, is an invasive species in Great Britain (GB) which is undergoing rapid population expansion in the wild. Although it has been suggested that RNPs could be a potential source of infectious disease, l... Read More about Psittacine beak and feather disease in a free-living ring-necked parakeet (Psittacula krameri) in Great Britain..

Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes (2014)
Journal Article
Sait, M., Livingstone, M., Clark, E. M., Wheelhouse, N., Spalding, L., Markey, B., Magnino, S., Lainson, F. A., Myers, G. S. A., & Longbottom, D. (2014). Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes. BMC Genomics, 15, 23. https://doi.org/10.1186/1471-2164-15-23

BACKGROUND: Chlamydia pecorum is the causative agent of a number of acute diseases, but most often causes persistent, subclinical infection in ruminants, swine and birds. In this study, the genome sequences of three C. pecorum strains isolated from t... Read More about Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes.

Risk factors associated with Lawsonia intracellularis in English pig farms (2013)
Journal Article
Bae, J. K., Wieland, B., Sait, M., Longbottom, D., Smith, D. G. E., Alarcon, P., & Wheelhouse, N. (2013). Risk factors associated with Lawsonia intracellularis in English pig farms. Veterinary Journal, 197(3), 707-711. https://doi.org/10.1016/j.tvjl.2013.03.020

Porcine proliferative enteropathy (PPE) caused by the bacterium Lawsonia intracellularis causes considerable economic loss to the pig industry. The objective of this study was to evaluate the seroprevalence of L. intracellularis exposure in different... Read More about Risk factors associated with Lawsonia intracellularis in English pig farms.

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep (2013)
Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., Wheelhouse, N., Dagleish, M., Aitchison, K., Wattegedera, S., Nath, M., Entrican, G., & Buxton, D. (2013). Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), Article e57950. https://doi.org/10.1371/journal.pone.0057950

BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is ab... Read More about Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep.

Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy (2013)
Journal Article
Sait, M., Aitchison, K., Wheelhouse, N., Wilson, K., Alex Lainson, F., Longbottom, D., & Smith, D. G. E. (2013). Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy. Genome Announcements, 1(1), https://doi.org/10.1128/genomeA.00027-13

Lawsonia intracellularis is the etiological agent of proliferative enteropathy (PE), causing mild or acute hemorrhagic diarrhea in infected animals. Here we report the genome sequence of strain N343, isolated from a sow that died of hemorrhagic PE. N... Read More about Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy.

Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle (2012)
Journal Article
Longbottom, D., Wheelhouse, N., Sait, M., Wilson, K., Aitchison, K., McLean, K., & Smith, D. G. E. (2012). Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle. Veterinary Microbiology, 160(3-4), 525-529. https://doi.org/10.1016/j.vetmic.2012.06.017

It has been suggested that polymorphic membrane proteins (Pmps) belonging to the Type V autotransporter protein family play an important role in the pathogenesis of Chlamydia abortus (C. abortus; formerly Chlamydophila abortus) infection. In a previo... Read More about Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle.

Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle (2012)
Journal Article
Wheelhouse, N. M., Sait, M., Aitchison, K., Livingstone, M., Wright, F., McLean, K., Inglis, N. F., Smith, D. G. E., & Longbottom, D. (2012). Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle. PLOS ONE, 7, Article e49190. https://doi.org/10.1371/journal.pone.0049190

BACKGROUND: Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membrane proteins (Pmps). While the total number of pmp genes varies between Chlamydia species, all encode a single pmpD gene. In both Chlamydia tracho... Read More about Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle.

Evaluation of the impact and control of enzootic abortion of ewes (2012)
Journal Article
Longbottom, D., Entrican, G., Wheelhouse, N., Brough, H., & Milne, C. (2013). Evaluation of the impact and control of enzootic abortion of ewes. Veterinary Journal, 195(2), 257-259. https://doi.org/10.1016/j.tvjl.2012.06.018

Despite the availability of effective management and treatment strategies, Chlamydia abortus remains the single most frequently diagnosed cause of infectious ovine abortion (enzootic abortion of ewes, EAE) in the UK and one of the most significant ca... Read More about Evaluation of the impact and control of enzootic abortion of ewes.

Involvement of Parachlamydia in bovine abortions in Scotland (2012)
Journal Article
Howie, F., Gidlow, J., Greub, G., Wheelhouse, N., Dagleish, M., & Longbottom, D. (2012). Involvement of Parachlamydia in bovine abortions in Scotland. Veterinary Journal, 193(2), 586-588. https://doi.org/10.1016/j.tvjl.2012.01.008

Bovine abortion represents a major animal welfare issue and a cause of substantial economic loss yet the rate of successful diagnosis remains low. Chlamydia-related organisms including Parachlamydia have recently emerged as putative cattle abortifaci... Read More about Involvement of Parachlamydia in bovine abortions in Scotland.

New challenges for vaccination to prevent chlamydial abortion in sheep (2011)
Journal Article
Entrican, G., Wheelhouse, N., Wattegedera, S. R., & Longbottom, D. (2012). New challenges for vaccination to prevent chlamydial abortion in sheep. Comparative Immunology, Microbiology and Infectious Diseases, 35(3), 271-276. https://doi.org/10.1016/j.cimid.2011.12.001

Ovine enzootic abortion (OEA) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. OEA remains a common cause of infectious abortion in many sheep-rearing countries despite the existence of commercially available vaccine... Read More about New challenges for vaccination to prevent chlamydial abortion in sheep.

Endemic and emerging chlamydial infections of animals and their zoonotic implications (2011)
Journal Article
Wheelhouse, N., & Longbottom, D. (2011). Endemic and emerging chlamydial infections of animals and their zoonotic implications. Transboundary and Emerging Diseases, 59(4), 283-291. https://doi.org/10.1111/j.1865-1682.2011.01274.x

The Chlamydiae are a diverse group of obligate intracellular Gram-negative bacteria that are known to infect a wide variety of host species and are responsible for a wide range of diseases in animals and man. Many of these organisms have been extensi... Read More about Endemic and emerging chlamydial infections of animals and their zoonotic implications.