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Outputs (36)

Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials (2022)
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022). Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429

Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes which are controlled by the nuclear erythroid 2-related factor 2 (NRF2) tra... Read More about Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials.

Case study 10: Facilitating education leadership: Building and sharing an understanding amongst the programme team (2022)
Book Chapter
Malone, E., & Yorkstone, S. (2022). Case study 10: Facilitating education leadership: Building and sharing an understanding amongst the programme team. In J. Lawrence, S. Morón-García, & R. Senior (Eds.), Supporting Course and Programme Leaders in Higher Education: Practical Wisdom for Leaders, Educational Developers and Programme Leaders (191-194). Routledge. https://doi.org/10.4324/9781003127413-37

This case study describes the process of building a programme roadmap to enable a shared understanding and sense of ownership with the various tasks involved in the management of a suite of undergraduate programmes. Collaboration with the institution... Read More about Case study 10: Facilitating education leadership: Building and sharing an understanding amongst the programme team.

How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts (2022)
Journal Article
Macdonald, I., Malone, E., & Firth, R. (2022). How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts. Studies in Higher Education, 47(9), 1980-1996. https://doi.org/10.1080/03075079.2021.2020745

In UK HE institutions there is a growing realisation and appreciation for academic disciplines to seek research partners beyond their own subject (QAA. 2018. Enterprise and entrepreneurship education: Guidance for UK higher education providers. Acces... Read More about How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts.

Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration (2021)
Journal Article
Kirkwood, L., Ingram-Sills, L., Taylor, M. D., Malone, E., & Florida-James, G. (2021). Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration. International Journal of Environmental Research and Public Health, 18(9), Article 4603. https://doi.org/10.3390/ijerph18094603

Introduction: Understanding the sport-specific immune response elicited during both training and competition is imperative to maximise athlete health and performance. Despite a growing population of professional enduro mountain bike athletes, little... Read More about Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration.

Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure (2019)
Journal Article
Kirkwood, L. A., Taylor, M. D., Ingram, L. A., Malone, E., & Florida-James, G. D. (2019). Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure. Journal of Science and Cycling, 8(1), 18-25. https://doi.org/10.28985/1906.jsc.04

Limited information is currently available regarding the hand-arm vibration (HAV) exposure 5 for professional off-road cyclists. Previous reports have suggested that commuting and 6 recreational cyclists are at risk of exceeding exposure limit values... Read More about Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure.

Building Ambitious Programme Communities: Generating the impetus for co-creation in Staff Student Liaison Committees (2019)
Presentation / Conference
Malone, E. (2019, January). Building Ambitious Programme Communities: Generating the impetus for co-creation in Staff Student Liaison Committees. Presented at Supporting Programme Leaders to Navigate (and Shape) the Data Landscape

QAA Evidence for Enhancement, Enhancing Programme Leadership event ‘Supporting Programme Leaders to Navigate (and Shape) the Data Landscape’ hosted by Heriot Watt in January 2019.

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men (2018)
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018). Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), Article e13697. https://doi.org/10.14814/phy2.13697

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T-cells (angiogenic T-cells; TANG) possess highly angiogenic capa... Read More about Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

Immunological responses to an international mountain bike enduro race (2018)
Presentation / Conference
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2018, April). Immunological responses to an international mountain bike enduro race. Poster presented at UK Exercise Immunology Specialist Interest Group Symposium, Loughborough, UK

Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2018, April). Immunological responses to an international mountain bike enduro race. Poster presented at UK Exercise Immunology Specialist Interest Group Symposium, Loughborou... Read More about Immunological responses to an international mountain bike enduro race.

Physiological characteristics and performance in elite enduro mountain biking (2017)
Journal Article
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2017). Physiological characteristics and performance in elite enduro mountain biking. Journal of Science and Cycling, 6(2), 13-21. https://doi.org/10.28985/171231.jsc.09

Enduro mountain bike racing is composed of several timed predominantly downhill race stages linked by time restricted, non-competitive transition stages. This study aimed to 1) detail and compare the laboratory assessed physiological characteristics... Read More about Physiological characteristics and performance in elite enduro mountain biking.

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Increase student ownership to build innovation and enterprise in the applied sciences classroom (2017)
Presentation / Conference
Malone, E., & Wright, G. (2017, February). Increase student ownership to build innovation and enterprise in the applied sciences classroom. Presented at The Teaching Fellows Conference, Edinburgh Napier University, Edinburgh

In response to the University’s 2020 Strategy: Building Success and particularly the objective, “to provide a learning environment that develops graduates who have enterprising and innovative mind-sets and who are well prepared to thrive in complex u... Read More about Increase student ownership to build innovation and enterprise in the applied sciences classroom.

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes (2016)
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956

Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is pr... Read More about Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. (2016)
Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September). Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference

The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditional assays to evaluate toxicity must be modified or validated to ensure... Read More about Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system..

A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells (2016)
Journal Article
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), 1253-1264. https://doi.org/10.1113/ep085771

New Findings What is the central question of the study? Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise? What is the main finding and its importance? Our study reveals that TANG cells are redistributed i... Read More about A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells.

Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections (2016)
Presentation / Conference
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September). Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece

Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Reduced bioavailability and sub-optimal doses can be responsible for generatio... Read More about Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections.

High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number (2016)
Presentation / Conference
Ross, M. D., Malone, E., Simpson, R., & Florida-James, G. (2016, May). High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number. Poster presented at American College of Sports Medicine (ACSM) Annual Congress, Boston

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related decline in blood vessel number and function; however the mechanisms are not... Read More about High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number.

The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections (2015)
Presentation / Conference
Oluwadare, E., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2015, August). The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites IX, Hydra, Greece

Billions of livestock, and a third of the current human population, are infected with helminth parasites. In livestock, these helminth infections are accompanied by significant morbidity and mortality, and although anthelmintic drugs are available, t... Read More about The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections.

The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression (2015)
Presentation / Conference
Ross, M., Malone, E., Simpson, R., & Florida-James., G. (2015, May). The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression. Poster presented at American College of Sports Medicine (ACSM) Annual Congress, Boston

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related decline in blood vessel number and function; however the mechanisms are not... Read More about The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression.

The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. (2015)
Conference Proceeding
Ross, M. D., Malone, E. M., Simpson, R. J., & Florida-James, G. (2015). The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Additionally, regular exercise is known to offset the age-related decline in blood vessel number and function. Circulating angio... Read More about The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression..

Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise (2015)
Journal Article
Florida-James, G. D., Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. (2015). Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise. Brain, Behavior, and Immunity, 47, 100-108. https://doi.org/10.1016/j.bbi.2014.12.018

Sleep disruption and deprivation are common in contemporary society and have been linked with poor health, decreased job performance and increased life-stress. The rapid redeployment of lymphocytes between the blood and tissues is an archetypal featu... Read More about Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise.

Can we enable students to reach their potential through engaging with feedback – a feedback pathway? (2015)
Presentation / Conference
Malone, E., & MacNab, A. (2015, January). Can we enable students to reach their potential through engaging with feedback – a feedback pathway?. Presented at The Teaching Fellows Conference, Edinburgh Napier University, Edinburgh

In response to our experience and supporting evidence [1] that students may not engage with, understand or use their feedback, we have created and introduced a ’feedback pathway’ into a level 9 module. This pathway promotes engagement with and the a... Read More about Can we enable students to reach their potential through engaging with feedback – a feedback pathway?.

Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity (2012)
Presentation / Conference
Nicol, L., Malone, E., & Proudfoot, L. (2012, April). Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity. Poster presented at British Society for Parasitology Conference, 50th Anniversary, Glasgow

Nanomaterials, having at least one dimension less than 100nm, have unique physico-chemical properties due to their small size, large surface area and surface reactivity. Manufactured nanomaterials have enormous potential in industrial, pharmaceutical... Read More about Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity.

Nanoparticles and Neutrophil Activation (2012)
Presentation / Conference
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February). Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland

Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are the predominant leukocyte (40-75%), and are positioned to rapidly migrate to... Read More about Nanoparticles and Neutrophil Activation.

Nanotoxicity. (2011)
Book Chapter
Hutchison, G. R., & Malone, E. M. (2011). Nanotoxicity. In B. Booß-Bavnbek, B. Klösgen, J. Larsen, F. Pociot, & E. Renström (Eds.), Systems Biology of Regulated Exocytosis in Pancreatic β-Cells, 419-434. Springer. https://doi.org/10.1007/978-1-4419-6956-9_18

Nanotechnology, including the field of nanomedicine, promises to revolutionise/improve the way in which we live our lives. This atomic, molecular and macromolecular technology will introduce nanoparticles into our environment and our daily routine. I... Read More about Nanotoxicity..

Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model. (2010)
Presentation / Conference
Fulton, N., Malone, E., O’Neil, M., & Hutchison, G. (2010, June). Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model. Poster presented at Nanotoxicology 2010, Edinburgh

Nanoparticles (NP) are sized between 1 and 100 nanometers and are currently the subject of significant research due to their important role in the biomedical, materials and cosmetics industries. Nanotoxicologists are working to understand the impact... Read More about Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model..

Immunomodulatory effects of cannabinoids in human T-lymphocytes (2009)
Conference Proceeding
Schinwald, A., Galban-Horcajo, F., Malone, E., & Smith, P. (2009). Immunomodulatory effects of cannabinoids in human T-lymphocytes. In Proceedings of the British Pharmacological Society

Background: Circulating levels of endocannabinoids are elevated in obese and hyperglycaemic patients and may contribute to immune dysfunction in obesity and diabetes. Cannabinoids have been shown to evoke both pro-and anti-inflammatory responses, act... Read More about Immunomodulatory effects of cannabinoids in human T-lymphocytes.

Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. (2005)
Journal Article
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E., & Maizels, R. M. (2005). Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology, 174, 4924-4933

Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main determinant of parasite survival. In a laboratory model of infection, using... Read More about Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo..