Prof Gary Hutchison's Outputs (6)

Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ (2012)
Journal Article
Kermanizadeh, A., Brown, D. M., Hutchison, G. R., & Stone, V. (2012). Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ. Journal of Nanomedicine and Nanotechnology, 4, 157. https://doi.org/10.4172/2157-7439.1000157

Background and methods: Following exposure via a number of routes (inhalation, ingestion or injection), some
Nanomaterials (NMs) translocate to secondary tissues, prominently the liver. This study investigated the effects of an
array of NMs, varyin... Read More about Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ.

An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials (2012)
Journal Article
Kermanizadeh, A., Gaiser, B. K., Hutchison, G. R., & Stone, V. (2012). An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. Particle and fibre toxicology, 9(1), 28. https://doi.org/10.1186/1743-8977-9-28

Background:
Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study... Read More about An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials.

Role of EGFR in intestinal barrier function in response to challenges with silver nanoparticles and enteric pathogens (2012)
Presentation / Conference Contribution
Sehgal, A., Hutchison, G., Proudfoot, L., Malone, E., Cameron, P., & Fraser-Pitt, D. (2012, July). Role of EGFR in intestinal barrier function in response to challenges with silver nanoparticles and enteric pathogens. Poster presented at Society for Applied Microbiology Summer Conference: Resistance, Adaptation and Bioremediation, Edinburgh

Comparison of the macrophage cell line NR8383 with primary lung macrophages (2012)
Journal Article
Wessels, A., Daly, P., Somers, G., Stone, V., Hutchison, G., & Hassall, D. (2012). Comparison of the macrophage cell line NR8383 with primary lung macrophages. Toxicology Letters, 211, S108. https://doi.org/10.1016/j.toxlet.2012.03.403

Nanoparticles and Neutrophil Activation (2012)
Presentation / Conference Contribution
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., Proudfoot, L., & Malone, E. (2012, February). Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland

Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are the predominant leukocyte (40-75%), and are positioned to rapidly migrate to... Read More about Nanoparticles and Neutrophil Activation.

In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers (2012)
Journal Article
Kermanizadeh, A., Pojana, G., Gaiser, B. K., Birkedal, R., Bilanicˇová, D., Wallin, H., Jensen, K. A., Sellergren, B., Hutchison, G. R., Marcomini, A., & Stone, V. (2013). In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology, 7(3), 301-313. https://doi.org/10.3109/17435390.2011.653416

Effects on the liver C3A cell line treated with a panel of engineered nanomaterials (NMs) consisting of two zinc oxide particles (ZnO; coated 100 nm and uncoated 130 nm), two multi-walled carbon nanotubes (MWCNTs), one silver (Ag < 20 nm), one 7 nm a... Read More about In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers.