Ali Kermanizadeh
In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers.
Authors
Giulio Pojana
Birgit K Gaiser
Renie Birkedal
Dagmar
Wallin
Keld Alstrup Jensen
Sellergren
Prof Gary Hutchison Ga.Hutchison@napier.ac.uk
Dean of Applied Sciences
Antonio Marcomini
Vicki Stone
Abstract
Effects on the liver C3A cell line treated with a panel of engineered nanomaterials (NMs) consisting of two zinc oxide particles (ZnO; coated 100 nm and uncoated 130 nm), two multi-walled carbon nanotubes (MWCNTs), one silver (Ag < 20 nm), one 7 nm anatase, two rutile TiO2 nanoparticles (10 and 94 nm) and two derivatives with positive and negative covalent functionalisation of the 10 nm rutile were evaluated. The silver particles elicited the greatest level of cytotoxicity (24 h LC50 – 2 µg/cm2). The silver was followed by the uncoated ZnO (24 h LC50 – 7.5 µg/cm2) and coated ZnO (24 h LC50 – 15 µg/cm2) particles with respect to cytotoxicity. The ZnO NMs were found to be about 50–60% soluble which could account for their toxicity. By contrast, the Ag was
Citation
Kermanizadeh, A., Pojana, G., Gaiser, B. K., Birkedal, R., Bilanicˇová, D., Wallin, H., …Stone, V. (2013). In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology, 7, 301-313. https://doi.org/10.3109/17435390.2011.653416
Journal Article Type | Article |
---|---|
Publication Date | 2013 |
Deposit Date | Mar 27, 2014 |
Print ISSN | 1743-5390 |
Electronic ISSN | 1743-5404 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 7 |
Pages | 301-313 |
DOI | https://doi.org/10.3109/17435390.2011.653416 |
Keywords | Liver; inflammation; IL-8; albumin; urea; |
Public URL | http://researchrepository.napier.ac.uk/id/eprint/6670 |
Publisher URL | http://dx.doi.org/10.3109/17435390.2011.653416 |
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