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All Outputs (7)

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes (2016)
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956

Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is pr... Read More about Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. (2016)
Presentation / Conference Contribution
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September). Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11t

The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditional assays to evaluate toxicity must be modified or validated to ensure... Read More about Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system..

A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells (2016)
Journal Article
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angio

New Findings What is the central question of the study? Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise? What is the main finding and its importance? Our study reveals that TANG cells are redistributed i... Read More about A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells.

Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections (2016)
Presentation / Conference Contribution
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September). Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Mol

Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Reduced bioavailability and sub-optimal doses can be responsible for generatio... Read More about Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections.

High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number (2016)
Presentation / Conference Contribution
Ross, M. D., Malone, E., Simpson, R., & Florida-James, G. (2016, May). High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number. Poster presented at American College of Sports Medicine (ACSM) Annual C

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related decline in blood vessel number and function; however the mechanisms are not... Read More about High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number.