All Outputs (84)

Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution (2024)
Journal Article
Lankester, F., Kibona, T. J., Allan, K. J., de Glanville, W., Buza, J. J., Katzer, F., Halliday, J. E., Mmbaga, B. T., Wheelhouse, N., Innes, E. A., Thomas, K. M., Nyasebwa, O. M., Swai, E., Claxton, J. R., & Cleaveland, S. (in press). Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution. eLife, 13, RP95296. https://doi.org/10.7554/elife.95296

Lack of data on the aetiology of livestock diseases constrains effective interventions to improve livelihoods, food security and public health. Livestock abortion is an important disease syndrome affecting productivity and public health. Several path... Read More about Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution.

The potential virulence of Listeria monocytogenes strains isolated from fresh produce processing facilities as determined by an invertebrate Galleria mellonella model (2024)
Journal Article
Umaru, B., de Llanos Frutos, R., Donnellan, S., Smith, A., Flockhart, A., Singleton, I., & Wheelhouse, N. (2024). The potential virulence of Listeria monocytogenes strains isolated from fresh produce processing facilities as determined by an invertebrate Galleria mellonella model. PLOS ONE, 19(12), e0311839. https://doi.org/10.1371/journal.pone.0311839

Listeria monocytogenes, a bacterium responsible for listeriosis, is an environmental and food-borne pathogen that poses a particular risk to pregnant women and the elderly. While traditionally associated with animal products, ready-to-eat salads are... Read More about The potential virulence of Listeria monocytogenes strains isolated from fresh produce processing facilities as determined by an invertebrate Galleria mellonella model.

Environmental and food security implications of livestock abortions and calf mortality: a case study in Kenya and Tanzania (2024)
Journal Article
Gurmu, E. B., Bronsvoort, B., Cook, E. A. J., Lankester, F., Özkan, Ş., Rosenstein, P. K., Semango, G., Wheelhouse, N., Wilkes, A., & Arndt, C. (2024). Environmental and food security implications of livestock abortions and calf mortality: a case study in Kenya and Tanzania. Frontiers in Sustainable Food Systems, 8, Article 1390047. https://doi.org/10.3389/fsufs.2024.1390047

This study investigates the environmental and food security implications of livestock abortions and calf mortality in Tanzanian dairy systems and Kenyan beef systems by utilizing data from previously published studies. The environmental impact of liv... Read More about Environmental and food security implications of livestock abortions and calf mortality: a case study in Kenya and Tanzania.

Evaluation of the protective efficacy of different doses of a Chlamydia abortus subcellular vaccine in a pregnant sheep challenge model for ovine enzootic abortion (2024)
Journal Article
Livingstone, M., Aitchison, K., Palarea-Albaladejo, J., Chianini, F., Silvia Rocchi, M., Gastón Caspe, S., Underwood, C., Flockhart, A., Wheelhouse, N., Entrican, G., Ranjan Wattegedera, S., & Longbottom, D. (2024). Evaluation of the protective efficacy of different doses of a Chlamydia abortus subcellular vaccine in a pregnant sheep challenge model for ovine enzootic abortion. Animals, 14(20), Article 3004. https://doi.org/10.3390/ani14203004

Chlamydia abortus causes the disease ovine enzootic abortion, which is one of the most infectious causes of foetal death in small ruminants worldwide. While the disease can be controlled using live and inactivated commercial vaccines, there is scope... Read More about Evaluation of the protective efficacy of different doses of a Chlamydia abortus subcellular vaccine in a pregnant sheep challenge model for ovine enzootic abortion.

Q fever and Coxiellosis implications for livestock and human health: a UK perspective (2023)
Journal Article
Wheelhouse, N., Vazquez, R., Viora, L., & Halliday, J. E. (2023). Q fever and Coxiellosis implications for livestock and human health: a UK perspective. Livestock, 28(5), 193-238. https://doi.org/10.12968/live.2023.28.5.221

Q fever is a disease which can cause an acute self-limiting infection or long-term chronic condition in people exposed to the bacteria Coxiella burnetii. Most human cases in the UK are associated with livestock, particularly small ruminants, which ac... Read More about Q fever and Coxiellosis implications for livestock and human health: a UK perspective.

Seroprevalence and risk factors for Q-fever (Coxiella burnetii) exposure in smallholder dairy cattle in Tanzania (2022)
Journal Article
Festo Bwatota, S., Mkilema Shirima, G., Hernandez-Castro, L. E., Mark de Clare Bronsvoort, B., Wheelhouse, N., Joseph Mengele, I., Kiyabo Motto, S., Mushumbusi Komwihangilo, D., Lyatuu, E., & Cook, E. A. J. (2022). Seroprevalence and risk factors for Q-fever (Coxiella burnetii) exposure in smallholder dairy cattle in Tanzania. Veterinary Sciences, 9(12), Article 662. https://doi.org/10.3390/vetsci9120662

Q fever is a zoonotic disease, resulting from infection with Coxiella burnetii. Infection in cattle can cause abortion and infertility, however, there is little epidemiological information regarding the disease in dairy cattle in Tanzania. Between Ju... Read More about Seroprevalence and risk factors for Q-fever (Coxiella burnetii) exposure in smallholder dairy cattle in Tanzania.

Epidemiology of q-fever in domestic ruminants and humans in Africa: A systematic review (2022)
Journal Article
Festo Bwatota, S., Cook, E. A. J., Mark de Clare Bronsvoort, B., Wheelhouse, N., Hernandez-Castor, L. E., & Mkilema Shirima, G. (2022). Epidemiology of q-fever in domestic ruminants and humans in Africa: A systematic review. CABI One Health, https://doi.org/10.1079/cabionehealth.2022.0008

Q-fever is a zoonotic infectious disease caused by the gram-negative, intracellular, spore-forming bacterium Coxiella burnetii. Infected ruminants (cattle, sheep, and goats) are the reservoirs of the pathogen and thus an important source of infection... Read More about Epidemiology of q-fever in domestic ruminants and humans in Africa: A systematic review.

Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya (2022)
Journal Article
Muema, J., Nyamai, M., Wheelhouse, N., Njuguna, J., Jost, C., Oyugi, J., Bukania, Z., Oboge, H., Ogoti, B., Makori, A., Fernandez, M. D. P., Omulo, S., & Thumbi, S. (2022). Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya. Heliyon, 8(10), Article e11133. https://doi.org/10.1016/j.heliyon.2022.e11133

Background
Coxiella burnetti can be transmitted to humans primarily through inhaling contaminated droplets released from infected animals or consumption of contaminated dairy products. Despite its zoonotic nature and the close association pastoralis... Read More about Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya.

Modelling the Transmission of Coxiella burnetii within a UK Dairy Herd: Investigating the Interconnected Relationship between the Parturition Cycle and Environment Contamination (2022)
Journal Article
Patsatzis, D. G., Wheelhouse, N., & Tingas, E.-A. (2022). Modelling the Transmission of Coxiella burnetii within a UK Dairy Herd: Investigating the Interconnected Relationship between the Parturition Cycle and Environment Contamination. Veterinary Sciences, 9(10), Article 522. https://doi.org/10.3390/vetsci9100522

Q fever infection in dairy herds is introduced through the transmission of the bacterium Coxiella burnetii, resulting in multiple detrimental effects such as reduction of lactation, abortions and chronic infection. Particularly in the UK, recent evid... Read More about Modelling the Transmission of Coxiella burnetii within a UK Dairy Herd: Investigating the Interconnected Relationship between the Parturition Cycle and Environment Contamination.

Editorial: New Approaches to Understanding Vector Borne Diseases in Domestic and Wild animals (2022)
Journal Article
Cook, E. A., Wheelhouse, N., Larska, M., & Obanda, V. (2022). Editorial: New Approaches to Understanding Vector Borne Diseases in Domestic and Wild animals. Frontiers in Veterinary Science, 9, Article 1009751. https://doi.org/10.3389/fvets.2022.1009751

Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania (2022)
Journal Article
Thomas, K. M., Kibona, T., Claxton, J. R., de Glanville, W. A., Lankester, F., Amani, N., Buza, J. J., Carter, R. W., Chapman, G. E., Crump, J. A., Dagleish, M. P., Halliday, J. E. B., Hamilton, C. M., Innes, E. A., Katzer, F., Livingstone, M., Longbottom, D., Millins, C., Mmbaga, B. T., Mosha, V., …Allan, K. J. (2022). Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania. Scientific Reports, 12(1), Article 11669. https://doi.org/10.1038/s41598-022-15517-8

Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abort... Read More about Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania.

Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease (2022)
Journal Article
Turin, L., Surini, S., Wheelhouse, N., & Rocchi, M. S. (2022). Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease. Veterinary Research, 53(1), Article 37. https://doi.org/10.1186/s13567-022-01052-x

Environmental transmission of Chlamydia abortus as a result of enzootic disease or disease outbreaks and the threats posed by this pathogen has been previously reported, however a state-of-the-science review of these reports and the identification of... Read More about Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease.

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle (2021)
Journal Article
Wheelhouse, N., Hearn, J., Livingstone, M., Flockhart, A., Dagleish, M., & Longbottom, D. (2022). Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle. Journal of Applied Microbiology, 132(4), 2642-2648. https://doi.org/10.1111/jam.15422

Aims
The order Chlamydiales comprises a broad range of bacterial pathogens and endosymbionts, which infect a wide variety of host species. Within this order, members of the family Parachlamydiaceae, which includes Parachlamydia and Neochlamydia spec... Read More about Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle.

Q fever and early pregnancy failure: a Scottish case control study (2021)
Journal Article
Wheelhouse, N., Kemp, S., Halliday, J. E. B., Tingas, E. A., Duncan, W. C., & Horne, A. W. (2022). Q fever and early pregnancy failure: a Scottish case control study. Reproduction and Fertility, 3(1), https://doi.org/10.1530/raf-21-0072

Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion (2021)
Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., Wilson, K., Chianini, F., Silvia Rocchi, M., Wheelhouse, N., Entrican, G., & Longbottom, D. (2021). Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), Article 898. https://doi.org/10.3390/vaccines9080898

Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of... Read More about Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion.

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells (2021)
Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021). Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069

Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause reproductive complications including problems in conceiving a pregnancy th... Read More about Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells.

Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania (2020)
Journal Article
Theonest, N. O., Carter, R. W., Kasagama, E., Keyyu, J. D., Shirima, G. M., Tarimo, R., Thomas, K. M., Wheelhouse, N., Maro, V. P., Haydon, D. T., Buza, J. J., Allan, K. J., & Halliday, J. E. (2021). Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania. Veterinary Medicine and Science, 7(3), 960-967. https://doi.org/10.1002/vms3.401

Coxiella burnetii is an obligate intracellular bacterium that causes Q fever, a zoonotic disease of public health importance. In northern Tanzania, Q fever is a known cause of human febrile illness, but little is known about its distribution in anima... Read More about Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania.

Association of past Chlamydia trachomatis infection with miscarriage: Chlamydia trachomatis infection and miscarriage (2020)
Journal Article
Horne, A. W., Wheelhouse, N., Horner, P. J., & Duncan, W. C. (2020). Association of past Chlamydia trachomatis infection with miscarriage: Chlamydia trachomatis infection and miscarriage. JAMA Network Open, 3(10), Article e2018799. https://doi.org/10.1001/jamanetworkopen.2020.18799

Defining immune correlates during latent and active chlamydial infection in sheep (2020)
Journal Article
Ranjan Wattegedera, S., Livingstone, M., Maley, S., Rocchi, M., Lee, S., Pang, Y., Wheelhouse, N. M., Aitchison, K., Palarea-Albaladejo, J., Buxton, D., Longbottom, D., & Entrican, G. (2020). Defining immune correlates during latent and active chlamydial infection in sheep. Veterinary Research, 51, Article 75 (2020). https://doi.org/10.1186/s13567-020-00798-6

Ovine enzootic abortion (OEA) caused by the obligate intracellular bacterial pathogen Chlamydia abortus (C. abortus), is an endemic disease in most sheep-rearing countries worldwide. Following infection, C. abortus establishes a complex host–pathogen... Read More about Defining immune correlates during latent and active chlamydial infection in sheep.

Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning (2019)
Journal Article
Longbottom, D., Livingstone, M., Aitchison, K. D., Imrie, L., Manson, E., Wheelhouse, N., & Inglis, N. F. (2019). Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning. PLOS ONE, 14(10), Article e0224070. https://doi.org/10.1371/journal.pone.0224070

Data are presented on the identification and partial characterisation of proteins comprising the chlamydial outer membrane complex (COMC) fraction of Chlamydia abortus (C. abortus)—the aetiological agent of ovine enzootic abortion. Inoculation with t... Read More about Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning.