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Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania

Thomas, Kate M.; Kibona, Tito; Claxton, John R.; de Glanville, William A.; Lankester, Felix; Amani, Nelson; Buza, Joram J.; Carter, Ryan W.; Chapman, Gail E.; Crump, John A.; Dagleish, Mark P.; Halliday, Jo E. B.; Hamilton, Clare M.; Innes, Elisabeth A.; Katzer, Frank; Livingstone, Morag; Longbottom, David; Millins, Caroline; Mmbaga, Blandina T.; Mosha, Victor; Nyarobi, James; Nyasebwa, Obed M.; Russell, George C.; Sanka, Paul N.; Semango, George; Wheelhouse, Nick; Willett, Brian J.; Cleaveland, Sarah; Allan, Kathryn J.


Kate M. Thomas

Tito Kibona

John R. Claxton

William A. de Glanville

Felix Lankester

Nelson Amani

Joram J. Buza

Ryan W. Carter

Gail E. Chapman

John A. Crump

Mark P. Dagleish

Jo E. B. Halliday

Clare M. Hamilton

Elisabeth A. Innes

Frank Katzer

Morag Livingstone

David Longbottom

Caroline Millins

Blandina T. Mmbaga

Victor Mosha

James Nyarobi

Obed M. Nyasebwa

George C. Russell

Paul N. Sanka

George Semango

Brian J. Willett

Sarah Cleaveland

Kathryn J. Allan


Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abortion in Africa, including in subsistence farming communities that are critically dependent on livestock for food, income, and wellbeing. We conducted a prospective cohort study of livestock abortion, supported by cross-sectional serosurveillance, to determine aetiologies of livestock abortions in livestock in Tanzania. This approach generated several important findings including detection of a Rift Valley fever virus outbreak in cattle; high prevalence of C. burnetii infection in livestock; and the first report of Neospora caninum, Toxoplasma gondii, and pestiviruses associated with livestock abortion in Tanzania. Our approach provides a model for abortion surveillance in resource-limited settings. Our findings add substantially to current knowledge in sub-Saharan Africa, providing important evidence from which to prioritise disease interventions.

Journal Article Type Article
Acceptance Date Jun 24, 2022
Online Publication Date Jul 8, 2022
Publication Date 2022
Deposit Date Jul 11, 2022
Publicly Available Date Jul 11, 2022
Journal Scientific Reports
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Article Number 11669
Public URL


Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania (1.4 Mb)

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Copyright Statement
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