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Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania

Thomas, Kate M.; Kibona, Tito; Claxton, John R.; de Glanville, William A.; Lankester, Felix; Amani, Nelson; Buza, Joram J.; Carter, Ryan W.; Chapman, Gail E.; Crump, John A.; Dagleish, Mark P.; Halliday, Jo E. B.; Hamilton, Clare M.; Innes, Elisabeth A.; Katzer, Frank; Livingstone, Morag; Longbottom, David; Millins, Caroline; Mmbaga, Blandina T.; Mosha, Victor; Nyarobi, James; Nyasebwa, Obed M.; Russell, George C.; Sanka, Paul N.; Semango, George; Wheelhouse, Nick; Willett, Brian J.; Cleaveland, Sarah; Allan, Kathryn J.

Authors

Kate M. Thomas

Tito Kibona

John R. Claxton

William A. de Glanville

Felix Lankester

Nelson Amani

Joram J. Buza

Ryan W. Carter

Gail E. Chapman

John A. Crump

Mark P. Dagleish

Jo E. B. Halliday

Clare M. Hamilton

Elisabeth A. Innes

Frank Katzer

Morag Livingstone

David Longbottom

Caroline Millins

Blandina T. Mmbaga

Victor Mosha

James Nyarobi

Obed M. Nyasebwa

George C. Russell

Paul N. Sanka

George Semango

Brian J. Willett

Sarah Cleaveland

Kathryn J. Allan



Abstract

Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abortion in Africa, including in subsistence farming communities that are critically dependent on livestock for food, income, and wellbeing. We conducted a prospective cohort study of livestock abortion, supported by cross-sectional serosurveillance, to determine aetiologies of livestock abortions in livestock in Tanzania. This approach generated several important findings including detection of a Rift Valley fever virus outbreak in cattle; high prevalence of C. burnetii infection in livestock; and the first report of Neospora caninum, Toxoplasma gondii, and pestiviruses associated with livestock abortion in Tanzania. Our approach provides a model for abortion surveillance in resource-limited settings. Our findings add substantially to current knowledge in sub-Saharan Africa, providing important evidence from which to prioritise disease interventions.

Journal Article Type Article
Acceptance Date Jun 24, 2022
Online Publication Date Jul 8, 2022
Publication Date 2022
Deposit Date Jul 11, 2022
Publicly Available Date Jul 11, 2022
Journal Scientific Reports
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Article Number 11669
DOI https://doi.org/10.1038/s41598-022-15517-8
Public URL http://researchrepository.napier.ac.uk/Output/2885787

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Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania (1.4 Mb)
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http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.




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