Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3
(2022)
Journal Article
Hind, C., Clifford, M., Woolley, C., Harmer, J., McGee, L. M., Tyson-Hirst, I., Tait, H. J., Brooke, D. P., Dancer, S. J., Hunter, I. S., Suckling, C. J., Beveridge, R., Parkinson, J. A., Sutton, J. M., & Scott, F. J. (2022). Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3. ACS Infectious Diseases, 8(12), 2552-2563. https://doi.org/10.1021/acsinfecdis.2c00445
MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of Clostridioides difficile associated disease. Its precise mechanism of action... Read More about Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3.