All Outputs (11)

The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First? (1999)
Book Chapter
Darlison, M. G., & Richter, D. (1999). The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?. In D. Richter (Ed.), Regulatory Peptides and Cognate Receptors (1-11). Berlin: Springer. https://doi.org/10.1007/978-3-540-49421-8_1

As will be evident from the other chapters in this Volume, small peptide molecules regulate a wide variety of biological processes in both vertebrate and invertebrate species. For each bioactive peptide there exists one or more specific membrane-boun... Read More about The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?.

GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness (1996)
Book Chapter
Darlison, M. G., & Harvey, R. J. (1996). GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness. In Molecular Biology of Membrane Transport Disorders, 169-180. Springer Verlag. https://doi.org

Rapid chemical communication between cells in the vertebrate central nervous system is mediated by ligand-gated ion-channel receptors (also called ionotropic receptors), which are multisubunit complexes, that each contain an ion-selective channel. In... Read More about GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness.

Molecular Characterization of GABA-Gated Chloride Ion Channels from Complex and Simple Nervous Systems (1994)
Book Chapter
Darlison, M. G. (1994). Molecular Characterization of GABA-Gated Chloride Ion Channels from Complex and Simple Nervous Systems. In C. Peracchia (Ed.), Handbook of Membrane Channels, 303-315. Academic Press Books. https://doi.org/10.1016/b978-0-12-550640-3

No abstract available.

Molluscan ligand-gated ion-channel receptors (1993)
Book Chapter
Darlison, M. G., Hutton, M. L., & Harvey, R. J. (1993). Molluscan ligand-gated ion-channel receptors. In Comparative Molecular Neurobiology, 48-64. Springer Verlag. https://doi.org/10.1007/978-3-0348-7265-2_3

In this chapter we introduce the reader to the structures of the different types of ligand-gated ion-channel receptor, and the numerous receptor subtypes that have recently been revealed to exist, in both invertebrate and vertebrate species, by the a... Read More about Molluscan ligand-gated ion-channel receptors.

The Isolation of Genomic DNA from Invertebrates (1992)
Book Chapter
Vreugdenhil, E., & Darlison, M. G. (1992). The Isolation of Genomic DNA from Invertebrates. In A. Longstaff, & P. Revest (Eds.), Protocols in Molecular Neurobiology, 15-24. Springer Verlag. https://doi.org/10.1385/0-89603-199-3%3A15

Generally, genomic DNA is used either for the construction of genomic libraries or for Southern blot analysis. For several reasons, it is frequently preferable in the field of invertebrate neurobiology to screen, at least initially, genomic rather th... Read More about The Isolation of Genomic DNA from Invertebrates.

Structural Characteristics of Cation and Anion Channels Directly Operated by Agonists (1989)
Book Chapter
BARNARD, E., DARLISON, M., MARSHALL, J., & SATTELLE, D. (1989). Structural Characteristics of Cation and Anion Channels Directly Operated by Agonists. In Ion Transport, 159-181. Academic Press Books. https://doi.org/10.1016/b978-0-12-403985-8.50016-8

No abstract available.

The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies (1989)
Book Chapter
Darlison, M. G., Barnard, E. A., Bateson, A. N., Glencorse, T. A., Harvey, R. J., Hicks, A. A., …Wisden, W. (1989). The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies. In Molecular Biology of Neuroreceptors and I

It is well established that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) mediates many of its effects by binding to the GABAA receptor, which is present on the majority of mammalian brain neurons (Enna, 1983), resulting in the opening o... Read More about The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies.

Brain α-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors (1988)
Book Chapter
Darlison, M. G., Hicks, A. A., Cockcroft, V. B., Squire, M. D., & Barnard, E. A. (1988). Brain α-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors. In Cellular and Molecular Basis of Synaptic Transmission, 475-492. Springer Verlag. https

The study of the nicotinic acetylcholine receptor (AChR) of skeletal muscle and fish electric organ has been greatly facilitated by the application of the α-neurotoxins (postsynaptic toxins) of elapid and hydrophid snake venoms, such as α-bungarotoxi... Read More about Brain α-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors.

Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors (1988)
Book Chapter
Marshall, J., David, J. A., Darlison, M. G., Barnard, E. A., & Sattelle, D. B. (1988). Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors. In Nicotinic Acetylcholine Receptors in the Nervous System, 257-281. Springer Verlag.

There is considerable evidence that acetylcholine is an excitatory neurotransmitter at many synapses in the insect central nervous system (Sattelle 1986). Despite the acute technical difficulties of proving that a putative transmitter exerts a functi... Read More about Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors.

The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems (1986)
Book Chapter
Jackson, J. F., Beeson, D. M. W., Cockcroft, V. B., Darlison, M. G., Conti-Tronconi, B. M., Bell, L. D., & Barnard, E. A. (1986). The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems. Molecular Aspect

Nicotinic acetylcholine receptors (AChR) mediate chemical communication at synapses in many parts of the vertebrate nervous system, including neuromuscular junctions, autonomic ganglia, and certain sites in the brain. This occurs through the interact... Read More about The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems.

Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain (1986)
Book Chapter
Squire, M. D., Moss, S. J., Lai, F. A., Darlison, M. G., Cockcroft, V. B., Barnard, E. A., …Ross, S. J. (1986). Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain. In A. Maelicke (Ed.), Nicotinic Acetylcholine Receptor,

While it has been completely established that the AChR** as isolated from the electroplaques of electric fish is composed of four different polypeptides, such that its subunit structure is α2βγδ (as reviewed in detail elsewhere in this Volume), the e... Read More about Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain.