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Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube (2010)
Journal Article
Duncan, W. C., McDonald, S. E., Dickinson, R. E., Shaw, J. L. V., Lourenco, P. C., Wheelhouse, N., …Horne, A. W. (2010). Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Molecular Human Reproduction, 16, 950-959. https://doi.org/10.1093/molehr/gaq055

We investigated whether the repulsive SLIT/ROBO pathway is expressed in the endometrium and is negatively regulated during implantation. We also examined whether deficient expression in the Fallopian tube (FT) may predispose to ectopic pregnancy (EP)... Read More about Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube.

Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion (2010)
Journal Article
Wheelhouse, N., Aitchison, K., Laroucau, K., Thomson, J., & Longbottom, D. (2010). Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion. Vaccine, 28(35), 5657-5663. https://doi.org/10.1016/j.vaccine.2010.04.11

Chlamydophila abortus, the agent of ovine enzootic abortion (OEA), is a major cause of lamb mortality worldwide. Disease can be controlled through the use of vaccines based on the 1B temperature-sensitive mutant strain of C. abortus. This study inves... Read More about Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion.

Inflammatory cytokine responses in a pregnant mouse model of Chlamydophila abortus infection (2010)
Journal Article
Kerr, K., Wheelhouse, N., Livingstone, M., Anderson, I. E., Entrican, G., McKeever, D., & Longbottom, D. (2010). Inflammatory cytokine responses in a pregnant mouse model of Chlamydophila abortus infection. Veterinary Microbiology, 144(3-4), 392-398. http

Chlamydophila abortus (C. abortus) is the aetiological agent of ovine enzootic abortion (OEA). The highly elevated expression of the pro-inflammatory cytokine tumour necrosis factor-alpha (TNFα) and low-level expression of interferon-gamma (IFNγ) tha... Read More about Inflammatory cytokine responses in a pregnant mouse model of Chlamydophila abortus infection.

Transcriptional analysis of in vitro expression patterns of chlamydophila abortus polymorphic outer membrane proteins during the chlamydial developmental cycle. (2009)
Journal Article
Wheelhouse, N., Aitchison, K., Spalding, L., Livingstone, M., & Longbottom, D. (2009). Transcriptional analysis of in vitro expression patterns of chlamydophila abortus polymorphic outer membrane proteins during the chlamydial developmental cycle. Veterinary Research, 40(5), 47. https://doi.org/10.1051/vetres/2009030

Chlamydophila abortus is the aetiological agent of ovine enzootic abortion. Sequencing, annotation and comparative analysis of the genome of C. abortus strain S26/3 has revealed variation in the loci encoding the polymorphic membrane proteins (Pmps)... Read More about Transcriptional analysis of in vitro expression patterns of chlamydophila abortus polymorphic outer membrane proteins during the chlamydial developmental cycle..

Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. (2009)
Journal Article
Wheelhouse, N., Wattegedera, S., Stanton, J., Maley, S., Watson, D., Jepson, C., …Entrican, G. (2009). Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. Journal of Reproductive Immunology, 80(1-2), 49-56. https://

Chlamydophila abortus is a Gram-negative obligate intracellular bacterium that causes infectious abortion in sheep (ovine enzootic abortion, OEA) and humans. Infected placentas recovered from sheep that experience OEA have thickened membranes, contai... Read More about Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection..

Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett’s oesophagus (2009)
Journal Article
Tan, B., Skipworth, R., Stephens, N., Wheelhouse, N., Gilmour, H., De Beaux, A., …Ross, J. (2009). Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett’s oesophagus. European Journal of Cancer, 45(

Purpose: The mechanisms of the progression of Barrett’s oesophagus (BO) to oesophageal adenocarcinoma (OA) are poorly understood. The frequency of the 4977bp deletion in mitochondrial DNA (mtDNA) was investigated in specimens ranging from normal oes... Read More about Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett’s oesophagus.

Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection (2008)
Journal Article
King, A. E., Wheelhouse, N., Cameron, S., McDonald, S. E., Lee, K., Entrican, G., …Horne, A. W. (2009). Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. Human Reproduction, 24(3), 679-686. https://doi.org/10.1093/humrep/den452

BACKGROUND: Secretory leukocyte protease inhibitor (SLPI) and elafin are anti-protease and anti-microbial molecules with a role in innate immune defence. They have been demonstrated at multiple mucosal surfaces including those of the female reproduct... Read More about Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection.

Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: an unresolved paradox (2008)
Journal Article
Entrican, G., Wattegedera, S., Rocchi, M., & Wheelhouse, N. (2009). Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: an unresolved paradox. Veterinary Microbiology, 135(1-2), 98-102. https://doi.org/10.1016/j.vetmic.2008.09.028

Chlamydophila abortus infects the placental trophoblast in sheep, humans and mice, causing cell damage and inflammation that culminates in abortion. Host control of C. abortus appears to be heavily dependant on interferon (IFN)-gamma production. IFN-... Read More about Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: an unresolved paradox.

Molecular detection of Chlamydophila abortus in post-abortion sheep at oestrus and subsequent lambing (2008)
Journal Article
Livingstone, M., Wheelhouse, N., Maley, S. W., & Longbottom, D. (2009). Molecular detection of Chlamydophila abortus in post-abortion sheep at oestrus and subsequent lambing. Veterinary Microbiology, 135(1-2), 134-141. https://doi.org/10.1016/j.vetmic.200

Enzootic abortion of ewes (EAE), resulting from infection with the bacterium Chlamydophila abortus (C. abortus), is a major cause of lamb loss in Europe. The purpose of this study was to assess the potential impact of the shedding of organisms in pos... Read More about Molecular detection of Chlamydophila abortus in post-abortion sheep at oestrus and subsequent lambing.

Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract (2008)
Journal Article
Wheelhouse, N., Wattegedera, S., Fleming, D., Fitch, P., Kelly, R., & Entrican, G. (2008). Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract. Microbiology and Immunology, 52(9), 465-468. https://doi.org/10.1111/j.1348-0421.2008.00058.x

C. trachomatis and C. abortus are related Gram-negative intracellular bacteria that cause reproductive failure due to infertility (C. trachomatis) or abortion (C. abortus). These organisms target epithelial cells in the reproductive tract and/or plac... Read More about Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract.

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle (2007)
Journal Article
Qiu, G., Salto-Tellez, M., Ross, J. A., Yeo, W., Cui, Y., Wheelhouse, N., …Hooi, S. C. (2008). The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. Journal of Hepatolo

Background/Aims: The chromosome locus 3p21.3 is a ‘‘hot-spot” for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor su... Read More about The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.

Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat (2007)
Journal Article
Chu, M. M., Luyer, M. D. P., Wheelhouse, N. M., Bellamy, C. O., Greve, J. W. M., Buurman, W. A., …Wigmore, S. J. (2007). Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat. World Journal of Surgery, 31(

BACKGROUND: High-fat enteral nutrition reduces the inflammatory response following hemorrhagic shock in the rat. AIMS: We hypothesized that this intervention might also ameliorate the remote organ injury to the liver associated with this model. METHO... Read More about Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat.

Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma (2006)
Journal Article
Qui, G., Xie, H., Wheelhouse, N., Harrison, D., Chen, G. G., Salto-Tellez, M., …Hooi, S. C. (2007). Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. Journal of Hepatolog

BACKGROUND/AIMS: hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB, in normal tissues, and the expression and methylation status of hDAB2IPA in hepatocellular carcinomas (HCC) and cell... Read More about Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma.

The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes (2006)
Journal Article
Wheelhouse, N. M., Dowidar, N., Dejong, C. H. C., Garden, O. J., Powell, J. J., Barber, M. D., …Ross, J. A. (2006). The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes. International Journal of Molecular Medicine, 18(5), 957-961. https://doi.org/10.3892/ijmm.18.5.957

Macrophage inhibitory factor (MIF) is a pituitary peptide released during the physiological stress response, a T-cell product secreted during the antigen-specific response and a pro-inflammatory macrophage cytokine secreted after LPS stimulation. It... Read More about The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes.

Immunity in the female sheep reproductive tract (2006)
Journal Article
Entrican, G., & Wheelhouse, N. M. (2006). Immunity in the female sheep reproductive tract. Veterinary Research, 37(3), 295-309. https://doi.org/10.1051/vetres%3A2006002

Immune surveillance in the female reproductive tract is dependent on the interplay of many factors that include the expression of pattern recognition receptors on epithelial cells, resident leukocyte populations and hormones, none of which are unifor... Read More about Immunity in the female sheep reproductive tract.

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver (2005)
Journal Article
Wheelhouse, N. M., Lai, P. B. S., Wigmore, S. J., Ross, J. A., & Harrison, D. J. (2005). Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver. British Journal of Cancer, 92(7),

The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was c... Read More about Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver.

Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer (2004)
Journal Article
Halma, M., Wheelhouse, N., Barber, M., Powell, J., Fearon, K., & Ross, J. (2004). Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer. Human Immunology, 65(11), 1405-1408. https://doi.org/10.1016/j.humimm.2004.08.184

Despite progress in diagnosis and staging, pancreatic cancer still has a poor prognosis and it remains difficult to predict duration of survival in advanced pancreatic cancer. Nutritional decline, or cachexia, is a contributory factor to decreased su... Read More about Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer.

TNF-α induced DNA damage in primary murine hepatocytes (2003)
Journal Article
Chan, Y., Gillies, S., Ross, J., Harrison, D., Wheelhouse, N., Chan, Y., …Prost, S. (2003). TNF-α induced DNA damage in primary murine hepatocytes. International Journal of Molecular Medicine, 12(6), 889-894. doi:10.3892/ijmm.12.6.889

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, usually arising from a background of chronic inflammatory disease. Tumor necrosis factor alpha (TNF-alpha) is a pro-inflammatory cytokine produced in response to tissue injur... Read More about TNF-α induced DNA damage in primary murine hepatocytes.

Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. (1999)
Journal Article
Wheelhouse, N. M., Stubbs, A. K., Lomax, M. A., & MacRae, J. C. (1999). Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. Journal of Endocrinology, 163(2), 353-361. https://doi.org/10.1677/joe.0.1630353

Many of the anabolic effects of growth hormone (GH) are indirect, occurring through GH-stimulated production of insulin-like growth factor-I (IGF-I) by the liver. As well as being regulated by GH, plasma IGF-I concentrations have been demonstrated to... Read More about Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes..