Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2

Jeffreys, Laura N.; Pennington, Shaun H.; Duggan, Jack; Caygill, Claire H.; Lopeman, Rose C.; Breen, Alastair F.; Jinks, Jessica B.; Ardrey, Alison; Donnellan, Samantha; Patterson, Edward I.; Hughes, Grant L.; Hong, David W.; O'Neill, Paul M.; Aljayyoussi, Ghaith; Owen, Andrew; Ward, Stephen A; Biagini, Giancarlo A

doi:10.1016/j.ijantimicag.2022.106542

All Outputs (2)

A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection (2022)
Journal Article
Donnellan, S., Pennington, S. H., Ruggiero, A., Martinez-Rodriguez, C., Pouget, M., Thomas, J., Ward, S. A., Pollakis, G., Biagini, G. A., & Paxton, W. A. (2023). A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection. Journal of Infectious Diseases, 227(5), 708-713. https://doi.org/10.1093/infdis/jiac491

Mycobacterium tuberculosis and human immunodeficiency virus-1 (HIV-1) syndemic interactions are a major global health concern. Despite the clinical significance of coinfection, our understanding of the cellular pathophysiology and the therapeutic pha... Read More about A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection.

Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2 (2022)
Journal Article
Jeffreys, L. N., Pennington, S. H., Duggan, J., Caygill, C. H., Lopeman, R. C., Breen, A. F., Jinks, J. B., Ardrey, A., Donnellan, S., Patterson, E. I., Hughes, G. L., Hong, D. W., O'Neill, P. M., Aljayyoussi, G., Owen, A., Ward, S. A., & Biagini, G. A. (2022). Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2. International Journal of Antimicrobial Agents, 59(3), Article 106542. https://doi.org/10.1016/j.ijantimicag.2022.106542

A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advantages over monotherapies, including the potential to achieve greater efficacy... Read More about Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2.