Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes.

Wheelhouse, Nicholas M; Stubbs, A K; Lomax, M A; MacRae, J C

doi:10.1677/joe.0.1630353

Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat (2007)
Journal Article
Chu, M. M., Luyer, M. D. P., Wheelhouse, N. M., Bellamy, C. O., Greve, J. W. M., Buurman, W. A., Sangster, K., Fearon, K. C. H., Ross, J. A., Garden, O. J., Dejong, C. H. C., & Wigmore, S. J. (2007). Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat. World Journal of Surgery, 31(8), 1693-1701. https://doi.org/10.1007/s00268-007-9107-2

BACKGROUND: High-fat enteral nutrition reduces the inflammatory response following hemorrhagic shock in the rat. AIMS: We hypothesized that this intervention might also ameliorate the remote organ injury to the liver associated with this model. METHO... Read More about Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat.

Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma (2006)
Journal Article
Qui, G., Xie, H., Wheelhouse, N., Harrison, D., Chen, G. G., Salto-Tellez, M., Lai, P., Ross, J. A., & Hooi, S. C. (2007). Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. Journal of Hepatology, 46(4), 655-663. https://doi.org/10.1016/j.jhep.2006.11.012

BACKGROUND/AIMS: hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB, in normal tissues, and the expression and methylation status of hDAB2IPA in hepatocellular carcinomas (HCC) and cell... Read More about Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma.

The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes (2006)
Journal Article
Wheelhouse, N. M., Dowidar, N., Dejong, C. H. C., Garden, O. J., Powell, J. J., Barber, M. D., …Ross, J. A. (2006). The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes. International Journal of Molecular Medicine, 18(5), 957-961. https://doi.org/10.3892/ijmm.18.5.957

Macrophage inhibitory factor (MIF) is a pituitary peptide released during the physiological stress response, a T-cell product secreted during the antigen-specific response and a pro-inflammatory macrophage cytokine secreted after LPS stimulation. It... Read More about The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes.

Immunity in the female sheep reproductive tract (2006)
Journal Article
Entrican, G., & Wheelhouse, N. M. (2006). Immunity in the female sheep reproductive tract. Veterinary Research, 37(3), 295-309. https://doi.org/10.1051/vetres%3A2006002

Immune surveillance in the female reproductive tract is dependent on the interplay of many factors that include the expression of pattern recognition receptors on epithelial cells, resident leukocyte populations and hormones, none of which are unifor... Read More about Immunity in the female sheep reproductive tract.

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver (2005)
Journal Article
Wheelhouse, N. M., Lai, P. B. S., Wigmore, S. J., Ross, J. A., & Harrison, D. J. (2005). Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver. British Journal of Cancer, 92(7), 1268-1272. https://doi.org/10.1038/sj.bjc.6602496

The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was c... Read More about Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver.

Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer (2004)
Journal Article
Halma, M., Wheelhouse, N., Barber, M., Powell, J., Fearon, K., & Ross, J. (2004). Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer. Human Immunology, 65(11), 1405-1408. https://doi.org/10.1016/j.humimm.2004.08.184

Despite progress in diagnosis and staging, pancreatic cancer still has a poor prognosis and it remains difficult to predict duration of survival in advanced pancreatic cancer. Nutritional decline, or cachexia, is a contributory factor to decreased su... Read More about Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer.

TNF-α induced DNA damage in primary murine hepatocytes (2003)
Journal Article
Chan, Y., Gillies, S., Ross, J., Harrison, D., Wheelhouse, N., Chan, Y., …Prost, S. (2003). TNF-α induced DNA damage in primary murine hepatocytes. International Journal of Molecular Medicine, 12(6), 889-894. doi:10.3892/ijmm.12.6.889

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, usually arising from a background of chronic inflammatory disease. Tumor necrosis factor alpha (TNF-alpha) is a pro-inflammatory cytokine produced in response to tissue injur... Read More about TNF-α induced DNA damage in primary murine hepatocytes.

Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. (2002)
Journal Article
Stubbs, A. K., Wheelhouse, N. M., Lomax, M. A., & Hazlerigg, D. G. (2002). Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. Journal of Endocrinology, 174(2), 335-341. https://doi.org/10.1677/joe.0.1740335

This study tested the hypothesis that specific amino acids are responsible for modulating the insulin-like growth factor-I (IGF-I) response to growth hormone (GH) in ovine hepatocytes. Cells were grown in media of defined amino acid composition, base... Read More about Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression..

Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. (1999)
Journal Article
Wheelhouse, N. M., Stubbs, A. K., Lomax, M. A., & MacRae, J. C. (1999). Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. Journal of Endocrinology, 163(2), 353-361. https://doi.org/10.1677/joe.0.1630353

Many of the anabolic effects of growth hormone (GH) are indirect, occurring through GH-stimulated production of insulin-like growth factor-I (IGF-I) by the liver. As well as being regulated by GH, plasma IGF-I concentrations have been demonstrated to... Read More about Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes..

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