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Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression.

Stubbs, A K; Wheelhouse, Nicholas M; Lomax, M A; Hazlerigg, D G

Authors

A K Stubbs

M A Lomax

D G Hazlerigg



Abstract

This study tested the hypothesis that specific amino acids are responsible for modulating the insulin-like growth factor-I (IGF-I) response to growth hormone (GH) in ovine hepatocytes. Cells were grown in media of defined amino acid composition, based on physiological concentrations (P.C.) of amino acids in sheep plasma. Relative to culture in 5P.C., amino acid limitation to 0·2P.C. had inhibitory effects on IGF-I RNA expression, peptide release and p70 S6 kinase phosphorylation (P

Citation

Stubbs, A. K., Wheelhouse, N. M., Lomax, M. A., & Hazlerigg, D. G. (2002). Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. Journal of Endocrinology, 174(2), 335-341. https://doi.org/10.1677/joe.0.1740335

Journal Article Type Article
Online Publication Date Aug 1, 2002
Publication Date Aug 1, 2002
Deposit Date Jul 21, 2016
Journal Journal of Endocrinology
Print ISSN 0022-0795
Electronic ISSN 1479-6805
Publisher BioScientifica
Peer Reviewed Peer Reviewed
Volume 174
Issue 2
Pages 335-341
DOI https://doi.org/10.1677/joe.0.1740335
Keywords Ovine liver, animal biology, IGF-1 gene,
Public URL http://researchrepository.napier.ac.uk/Output/304739
Related Public URLs http://joe.endocrinology-journals.org/content/174/2/335.full.pdf