A K Stubbs
Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression.
Stubbs, A K; Wheelhouse, Nicholas M; Lomax, M A; Hazlerigg, D G
Abstract
This study tested the hypothesis that specific amino acids are responsible for modulating the insulin-like growth factor-I (IGF-I) response to growth hormone (GH) in ovine hepatocytes. Cells were grown in media of defined amino acid composition, based on physiological concentrations (P.C.) of amino acids in sheep plasma. Relative to culture in 5P.C., amino acid limitation to 0·2P.C. had inhibitory effects on IGF-I RNA expression, peptide release and p70 S6 kinase phosphorylation (P
Citation
Stubbs, A. K., Wheelhouse, N. M., Lomax, M. A., & Hazlerigg, D. G. (2002). Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. Journal of Endocrinology, 174(2), 335-341. https://doi.org/10.1677/joe.0.1740335
Journal Article Type | Article |
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Online Publication Date | Aug 1, 2002 |
Publication Date | Aug 1, 2002 |
Deposit Date | Jul 21, 2016 |
Journal | Journal of Endocrinology |
Print ISSN | 0022-0795 |
Electronic ISSN | 1479-6805 |
Publisher | BioScientifica |
Peer Reviewed | Peer Reviewed |
Volume | 174 |
Issue | 2 |
Pages | 335-341 |
DOI | https://doi.org/10.1677/joe.0.1740335 |
Keywords | Ovine liver, animal biology, IGF-1 gene, |
Public URL | http://researchrepository.napier.ac.uk/Output/304739 |
Related Public URLs | http://joe.endocrinology-journals.org/content/174/2/335.full.pdf |