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Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles (2016)
Journal Article
Piret, J.-P., Bondarenko, O. M., Boyles, M. S. P., Himly, M., Ribeiro, A. R., Benetti, F., Smal, C., Lima, B., Potthoff, A., Simion, M., Dumortier, E., Leite, P. E. C., Balottin, L. B., Granjeiro, J. M., Ivask, A., Kahru, A., Radauer-Preiml, I., Tischler, U., Duschl, A., Saout, C., …Toussaint, O. (2017). Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles. Archives of Toxicology, 91(6), 2315-2330. https://doi.org/10.1007/s00204-016-1897-2

The rapid development of nanotechnologies and increased production and use of nanomaterials raise concerns about their potential toxic effects for human health and environment. To evaluate the biological effects of nanomaterials, a set of reliable an... Read More about Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles.

An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine (2016)
Book Chapter
Boyles, M. S., Powell, L. G., Kermanizadeh, A., Johnston, H. J., Rothen-Rutishauser, B., Stone, V., & Clift, M. J. (2017). An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine. In Pharmaceutical Nanotechnology: Innovation and Production: Innovation and Production (443-468). Wiley. https://doi.org/10.1002/9783527800681.ch18

Nanotechnology, considered an industrial revolution occurring across the twentieth and twenty first centuries, promises to provide numerous advantages to both humans and the environment, across consumer, industrial, and technology sectors. Although a... Read More about An Overview of Nanoparticle Biocompatibility for Their Use in Nanomedicine.

Copper oxide nanoparticle toxicity profiling using untargeted metabolomics (2016)
Journal Article
Boyles, M. S. P., Ranninger, C., Reischl, R., Rurik, M., Tessadri, R., Kohlbacher, O., Duschl, A., & Huber, C. G. (2016). Copper oxide nanoparticle toxicity profiling using untargeted metabolomics. Particle and fibre toxicology, 13, Article 49. https://doi.org/10.1186/s12989-016-0160-6

Background
The rapidly increasing number of engineered nanoparticles (NPs), and products containing NPs, raises concerns for human exposure and safety. With this increasing, and ever changing, catalogue of NPs it is becoming more difficult to adequa... Read More about Copper oxide nanoparticle toxicity profiling using untargeted metabolomics.

Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses (2016)
Journal Article
Radauer-Preiml, I., Andosch, A., Hawranek, T., Luetz-Meindl, U., Wiederstein, M., Horejs-Hoeck, J., Himly, M., Boyles, M., & Duschl, A. (2016). Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses. Particle and fibre toxicology, 13, Article 3. https://doi.org/10.1186/s12989-016-0113-0

Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule ‘corona’. Hence, the ‘corona’ defines the biological identity of the ENMs and could affect the response o... Read More about Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses.

Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components (2015)
Journal Article
Boyles, M. S. P., Kristl, T., Andosch, A., Zimmermann, M., Tran, N., Casals, E., Himly, M., Puntes, V., Huber, C. G., Lütz-Meindl, U., & Duschl, A. (2015). Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components. Journal of Nanobiotechnology, 13, Article 84. https://doi.org/10.1186/s12951-015-0146-9

Background
Gold nanoparticles (AuNPs) are a popular choice for use in medical and biomedical research applications. With suitable functionalisation AuNPs can be applied in drug delivery systems, or can aid in disease diagnosis. One such functionalis... Read More about Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components.

Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions (2015)
Journal Article
Stoehr, L. C., Endes, C., Radauer-Preiml, I., Boyles, M. S. P., Casals, E., Balog, S., Pesch, M., Petri-Fink, A., Rothen-Rutishauser, B., Himly, M., Clift, M. J. D., & Duschl, A. (2015). Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions. Particle and fibre toxicology, 12, Article 29. https://doi.org/10.1186/s12989-015-0104-6

Background
Stably transfected lung epithelial reporter cell lines pose an advantageous alternative to replace complex experimental techniques to monitor the pro-inflammatory response following nanoparticle (NP) exposure. Previously, reporter cell li... Read More about Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions.

Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells (2015)
Journal Article
Stoehr, L. C., Madl, P., Boyles, M. S. P., Zauner, R., Wimmer, M., Wiegand, H., Andosch, A., Kasper, G., Pesch, M., Lütz-Meindl, U., Himly, M., & Duschl, A. (2015). Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells. Environmental Science and Technology, 49(14), 8721-8730. https://doi.org/10.1021/acs.est.5b02503

Air pollution is associated with increased risk of cardiovascular and pulmonary diseases, but conventional air quality monitoring gives no information about biological consequences. Exposing human lung cells at the air–liquid interface (ALI) to ambie... Read More about Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells.

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos (2015)
Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., Smail, F., Smith, P. J., Proudfoot, L., Windle, A. H., & Stone, V. (2015). Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012

The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods for CNT production, handling and disposal. In this study aspects reported to... Read More about Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos.

Workflows for automated downstream data analysis and visualization in large‐scale computational mass spectrometry (2015)
Journal Article
Aiche, S., Sachsenberg, T., Kenar, E., Walzer, M., Wiswedel, B., Kristl, T., Boyles, M., Duschl, A., Huber, C. G., Berthold, M. R., Reinert, K., & Kohlbacher, O. (2015). Workflows for automated downstream data analysis and visualization in large‐scale computational mass spectrometry. Proteomics, 15(8), 1443-1447. https://doi.org/10.1002/pmic.201400391

MS-based proteomics and metabolomics are rapidly evolving research fields driven by the development of novel instruments, experimental approaches, and analysis methods. Monolithic analysis tools perform well on single tasks but lack the flexibility t... Read More about Workflows for automated downstream data analysis and visualization in large‐scale computational mass spectrometry.

The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types (2015)
Journal Article
Schlinkert, P., Casals, E., Boyles, M., Tischler, U., Hornig, E., Tran, N., Zhao, J., Riediker, M., Himly, M., Oostingh, G. J., Puntes, V., & Duschl, A. (2015). The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types. Journal of Nanobiotechnology, 13, Article 1. https://doi.org/10.1186/s12951-014-0062-4

Background
Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems.... Read More about The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types.

Is the toxic potential of nanosilver dependent on its size? (2014)
Journal Article
Huk, A., Izak-Nau, E., Reidy, B., Boyles, M., Duschl, A., Lynch, I., & Dušinska, M. (2014). Is the toxic potential of nanosilver dependent on its size?. Particle and fibre toxicology, 11, Article 65. https://doi.org/10.1186/s12989-014-0065-1

Background
Nanosilver is one of the most commonly used engineered nanomaterials (ENMs). In our study we focused on assessing the size-dependence of the toxicity of nanosilver (Ag ENMs), utilising materials of three sizes (50, 80 and 200 nm) synthesi... Read More about Is the toxic potential of nanosilver dependent on its size?.

The Significance and Insignificance of Carbon Nanotube-Induced Inflammation (2014)
Journal Article
Boyles, M., Stoehr, L., Schlinkert, P., Himly, M., & Duschl, A. (2014). The Significance and Insignificance of Carbon Nanotube-Induced Inflammation. Fibers, 2(1), 45-74. https://doi.org/10.3390/fib2010045

In the present review article immune responses induced by carbon nanotubes (CNTs) are addressed. As inhalation is considered to be the primary entry route, and concern has been raised by similar high aspect ratio materials, the main focus lies on imm... Read More about The Significance and Insignificance of Carbon Nanotube-Induced Inflammation.

Human and natural environment effects of nanomaterials. Handbook of Nanophysics (2010)
Book Chapter
Gaiser, B., Clift, M. J., Johnston, H., Boyles, M. S., & Fernandes, T. F. (2010). Human and natural environment effects of nanomaterials. Handbook of Nanophysics. In K. D. Sattler (Ed.), Handbook of Nanophysics. Nanomedicine and Nanorobotics (14.1-14.26). CRC Press. https://doi.org/10.1201/9781420075496

In recent years, the importance of risk assessment in association with nanotechnology has been widely recognized by the scienti c community, governments, and regulating bodies. is was emphasized in 2004 in a report published by the Royal Society and... Read More about Human and natural environment effects of nanomaterials. Handbook of Nanophysics.

Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivityin vitroand inflammationin vivo (2010)
Journal Article
Rothen-Rutishauser, B., Brown, D. M., Piallier-Boyles, M., Kinloch, I. A., Windle, A. H., Gehr, P., & Stone, V. (2010). Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivityin vitroand inflammationin vivo. Nanotoxicology, 4(3), 331-342. https://doi.org/10.3109/17435390.2010.489161

Reactive oxygen species (ROS) production is important in the toxicity of pathogenic particles such as fibres. We examined the oxidative potential of straight (50 μm and 10 μm) and tangled carbon nanotubes in a cell free assay, in vitro and in vivo us... Read More about Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivityin vitroand inflammationin vivo.

An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signallingin vitro (2009)
Journal Article
Clift, M. J. D., Boyles, M. S. P., Brown, D. M., & Stone, V. (2010). An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signallingin vitro. Nanotoxicology, 4(2), 139-149. https://doi.org/10.3109/17435390903276925

The aim of this study was to investigate the ability of a series of different surface-coated quantum dots (QDs) to cause oxidative stress and affect cell signalling in J774.A1 macrophages. Organic QDs caused a significant (p < 0.001) decrease in glut... Read More about An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signallingin vitro.