Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses

Radauer-Preiml, Isabella; Andosch, Ancuela; Hawranek, Thomas; Luetz-Meindl, Ursula; Wiederstein, Markus; Horejs-Hoeck, Jutta; Himly, Martin; Boyles, Matthew; Duschl, Albert

Abstract

Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule ‘corona’. Hence, the ‘corona’ defines the biological identity of the ENMs and could affect the response of the immune system to ENM exposure. With up to 40 % of the world population suffering from type I allergy, a possible modulation of allergen effects by binding to ENMs is highly relevant with respect to work place and consumer safety. Therefore, the aim of this present study was to gain an insight into the interactions of gold nanoparticles with different seasonally and perennially occurring outdoor and indoor allergens.

Citation

Radauer-Preiml, I., Andosch, A., Hawranek, T., Luetz-Meindl, U., Wiederstein, M., Horejs-Hoeck, J., Himly, M., Boyles, M., & Duschl, A. (2016). Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses. Particle and fibre toxicology, 13, 3. https://doi.org/10.1186/s12989-016-0113-0

• Journal Article Type: Article
• Acceptance Date: Jan 4, 2016
• Online Publication Date: Jan 16, 2016
• Publication Date: 2016
• Deposit Date: Oct 13, 2023
• Publicly Available Date: Oct 16, 2023
• Print ISSN: 1743-8977
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Article Number: 3
• DOI: https://doi.org/10.1186/s12989-016-0113-0
• Keywords: Gold nanoparticles, Protein corona, Allergy, Basophil activation, Protease activity, A549 cells