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All Outputs (11)

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells (2016)
Presentation / Conference Contribution
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016). Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells

Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progression and poor prognosis. The molecular mechanisms driving neuroendocrine d... Read More about Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells.

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. (2016)
Presentation / Conference Contribution
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September). Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11t

The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditional assays to evaluate toxicity must be modified or validated to ensure... Read More about Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system..

In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome (2014)
Presentation / Conference Contribution
Girardi, G., Fraser, J., Bertolaccini, M. L., Lennen, R., Vontell, R., & Hutchison, G. (2014, December). In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome

Objectives: To use MRI-based methods to non invasively detect placental insufficiency and predict fetal outcomes in obstetric antiphospholipid syndrome (APS) Methods and result: A) Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles conjug... Read More about In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome.

Nanoparticles and Neutrophil Activation (2012)
Presentation / Conference Contribution
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February). Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Na

Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are the predominant leukocyte (40-75%), and are positioned to rapidly migrate to... Read More about Nanoparticles and Neutrophil Activation.

Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model. (2010)
Presentation / Conference Contribution
Fulton, N., Malone, E., O’Neil, M., & Hutchison, G. (2010, June). Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model. Poster presented at Nanotoxicology 2010, Edinburgh

Nanoparticles (NP) are sized between 1 and 100 nanometers and are currently the subject of significant research due to their important role in the biomedical, materials and cosmetics industries. Nanotoxicologists are working to understand the impact... Read More about Nanoparticles - a potential danger to male reproductive health? Development of in vitro testes model..

Androgen-dependent Sertoli cell proliferation as a target for endocrine disruptors relevant to human male reproductive health (2006)
Presentation / Conference Contribution
Scott, H., Hallmark, N., Saunders, P., Verhoeven, G., De Gendt, K., Hutchison, G., & Sharpe, R. (2006). Androgen-dependent Sertoli cell proliferation as a target for endocrine disruptors relevant to human male reproductive health. Endocrine abstracts,

Smoking by women during pregnancy can result in a 30–48% reduction in sperm count and testis size in the exposed offspring in adulthood, probably because of a decrease in the number of Sertoli cells. Until recently Sertoli cell proliferation was thou... Read More about Androgen-dependent Sertoli cell proliferation as a target for endocrine disruptors relevant to human male reproductive health.