Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide
(2004)
Journal Article
Lindahl, U., Li, J., Kusche-Gullberg, M., Salmivirta, M., Alaranta, S., Veromaa, T., Emeis, J., Roberts, I., Taylor, C., Oreste, P., Zoppetti, G., Naggi, A., Torri, G., & Casu, B. (2005). Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide. Journal of Medicinal Chemistry, 48(2), 349-352. https://doi.org/10.1021/jm049812m
Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activity of heparin depends on a specific pentasaccharide sequence that binds a... Read More about Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide.