Ulf Lindahl
Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide
Lindahl, Ulf; Li, Jin-ping; Kusche-Gullberg, Marion; Salmivirta, Markku; Alaranta, Sakari; Veromaa, Timo; Emeis, Jef; Roberts, Ian; Taylor, Clare; Oreste, Pasqua; Zoppetti, Giorgio; Naggi, Annamaria; Torri, Giangiacomo; Casu, Benito
Authors
Jin-ping Li
Marion Kusche-Gullberg
Markku Salmivirta
Sakari Alaranta
Timo Veromaa
Jef Emeis
Ian Roberts
Dr Clare Taylor Cl.Taylor@napier.ac.uk
Senior Lecturer
Pasqua Oreste
Giorgio Zoppetti
Annamaria Naggi
Giangiacomo Torri
Benito Casu
Abstract
Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activity of heparin depends on a specific pentasaccharide sequence that binds antithrombin. We report the generation of a product with antithrombin-binding, anticoagulant, and antithrombotic properties similar to those of heparin, through combined chemical and enzymatic modification of a bacterial (E. coli K5) polysaccharide. The process is readily applicable to large-scale production.
Journal Article Type | Article |
---|---|
Online Publication Date | Dec 31, 2004 |
Publication Date | Jan 27, 2005 |
Deposit Date | Jul 27, 2016 |
Journal | Journal of Medicinal Chemistry |
Print ISSN | 0022-2623 |
Electronic ISSN | 1520-4804 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 48 |
Issue | 2 |
Pages | 349-352 |
DOI | https://doi.org/10.1021/jm049812m |
Keywords | Thromboembolic disease, heparin |
Public URL | http://researchrepository.napier.ac.uk/Output/318128 |
You might also like
Recovery of MRSA and Clostridium difficile in an ICU ward
(2011)
Journal Article
Women in science: visible and vocal
(2013)
Other
Downloadable Citations
About Edinburgh Napier Research Repository
Administrator e-mail: repository@napier.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search