All Outputs (2)

Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice (2011)
Journal Article
Alam, C., Bittoun, E., Bhagwat, D., Valkonen, S., Saari, A., Jaakkola, U., …Hänninen, A. (2011). Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice. Diabetologia, 54, 1398-1406. https:/

Aims/hypothesis Microbial factors influence the development of diabetes in NOD mice. Studies in germ-free animals have revealed important roles of microbiota in the regulation of Th17 and forkhead box P3 (FOXP3)(+) T regulatory (Treg) activation in... Read More about Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice.

Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes (2011)
Journal Article
Hänninen, A., Maksimow, M., Alam, C., Morgan, D. J., & Jalkanen, S. (2011). Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes. European Journal of Immunology, 41(3), 634-644. https://doi.org/10.1002/eji.201040760

Ly6C is a murine cell-surface antigen expressed by plasma cells, subsets of myeloid cells and many T cells, including memory T cells. We previously documented that Ly6C crosslinking induces LFA-1 clustering on naïve CD8(+) T cells. Here, we show that... Read More about Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes.