Arno H�nninen
Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes
H�nninen, Arno; Maksimow, Mikael; Alam, Catharina; Morgan, David J; Jalkanen, Sirpa
Authors
Abstract
Ly6C is a murine cell-surface antigen expressed by plasma cells, subsets of myeloid cells and many T cells, including memory T cells. We previously documented that Ly6C crosslinking induces LFA-1 clustering on naïve CD8(+) T cells. Here, we show that in vitro and in vivo differentiation of naïve CD8(+) T cells into central (Tcm) but not effector (Tem) memory T cells enhances Ly6C expression, and its crosslinking induces strong LFA-1 clustering on Tcm. Blocking Ly6C function inhibits in vivo Tcm homing to LNs as efficiently as blocking L-selectin but it does not potentiate the inhibition provided by blocking either L-selectin or LFA-1 function. Thus, Ly6C, L-selectin and LFA-1 all appear to be part of a common homing pathway. In vitro, Ly6C crosslinking enhances Tcm adherence to ICAM-1 in the presence of CCL21. In summary, Tcm homing involves Ly6C, in addition to L-selectin and LFA-1, and appears to potentiate firm adhesion of Tcm to ICAM-1 in synergy with a chemokine. We propose that Ly6C augments Tcm compartmentalization into LNs during their homing.
Citation
Hänninen, A., Maksimow, M., Alam, C., Morgan, D. J., & Jalkanen, S. (2011). Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes. European Journal of Immunology, 41(3), 634-644. https://doi.org/10.1002/eji.201040760
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 21, 2010 |
Online Publication Date | Feb 10, 2011 |
Publication Date | 2011-03 |
Deposit Date | May 26, 2022 |
Journal | European journal of immunology |
Print ISSN | 0014-2980 |
Publisher | Wiley-VCH Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 41 |
Issue | 3 |
Pages | 634-644 |
DOI | https://doi.org/10.1002/eji.201040760 |
Keywords | Adhesion molecules, CD8 memory T cells, LFA-1, Ly6 family |
Public URL | http://researchrepository.napier.ac.uk/Output/2869992 |
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