All Outputs (4)

Diatom-inspired skeletonisation of insulin - Mechanistic insights into crystallisation and extracellular bioactivity (2015)
Journal Article
Véliz, D. S., Alam, C., Nietzel, T., Wyborski, R., Rivero-Müller, A., & Alam, P. (2015). Diatom-inspired skeletonisation of insulin - Mechanistic insights into crystallisation and extracellular bioactivity. Colloids and Surfaces B: Biointerfaces, 133, 140-147. https://doi.org/10.1016/j.colsurfb.2015.05.047

In this paper, we encage insulin within calcium carbonate by means of a biomineralisation process. We find that both dogbone and crossbone morphologies develop during the crystallisation process. The crystals break down into small nanocrystals after... Read More about Diatom-inspired skeletonisation of insulin - Mechanistic insights into crystallisation and extracellular bioactivity.

The amount of keratins matters for stress protection of the colonic epithelium (2015)
Journal Article
Asghar, M. N., Silvander, J. S. G., Helenius, T. O., Lähdeniemi, I. A. K., Alam, C., Fortelius, L. E., Holmsten, R. O., & Toivola, D. M. (2015). The amount of keratins matters for stress protection of the colonic epithelium. PLOS ONE, 10(5), Article e0127436. https://doi.org/10.1371/journal.pone.0127436

Keratins (K) are important for epithelial stress protection as evidenced by keratin mutations predisposing to human liver diseases and possibly inflammatory bowel diseases. A role for K8 in the colon is supported by the ulcerative colitis-phenotype w... Read More about The amount of keratins matters for stress protection of the colonic epithelium.

Peritoneal cavity is a route for gut-derived microbial signals to promote autoimmunity in non-obese diabetic mice (2015)
Journal Article
Emani, R., Alam, C., Pekkala, S., Zafar, S., Emani, M., & Hänninen, A. (2015). Peritoneal cavity is a route for gut-derived microbial signals to promote autoimmunity in non-obese diabetic mice. Scandinavian Journal of Immunology, 81(2), 102-109. https://doi.org/10.1111/sji.12253

Macrophages play a crucial role in innate immune reactions, and peritoneal macrophages (PMs) guard the sterility of this compartment mainly against microbial threat from the gut. Type 1 diabetes (T1D) is an autoimmune disease in which gut microbiota... Read More about Peritoneal cavity is a route for gut-derived microbial signals to promote autoimmunity in non-obese diabetic mice.

Keratins in health and disease (2015)
Journal Article
Toivola, D. M., Boor, P., Alam, C., & Strnad, P. (2015). Keratins in health and disease. Current Opinion in Cell Biology, 32, 73-81. https://doi.org/10.1016/j.ceb.2014.12.008

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and their inherited and spontaneous mutations give rise to keratinopathies. For example, mutations in K1/K5/K10/K14 cause epidermal skin diseases whereas simple ep... Read More about Keratins in health and disease.