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Keratins in health and disease

Toivola, Diana M; Boor, Peter; Alam, Catharina; Strnad, Pavel

Authors

Diana M Toivola

Peter Boor

Pavel Strnad



Abstract

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and their inherited and spontaneous mutations give rise to keratinopathies. For example, mutations in K1/K5/K10/K14 cause epidermal skin diseases whereas simple epithelial K8/K18/K19 variants predispose to development of several liver disorders. Due to their abundance, tissue- and context-specific expression, keratins constitute excellent diagnostic markers of both neoplastic and non-neoplastic diseases. During injury and in disease, keratin expression levels, cellular localization or posttranslational modifications are altered. Accumulating evidence suggests that these changes modulate multiple processes including cell migration, tumor growth/metastasis and development of infections. Therefore, our understanding of keratins is shifting from diagnostic markers to active disease modifiers.

Journal Article Type Article
Online Publication Date Jan 17, 2015
Publication Date 2015-02
Deposit Date May 26, 2022
Journal Current opinion in cell biology
Print ISSN 0955-0674
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 32
Pages 73-81
DOI https://doi.org/10.1016/j.ceb.2014.12.008
Public URL http://researchrepository.napier.ac.uk/Output/2869947
Publisher URL https://doi.org/10.1016/j.ceb.2014.12.008