Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain

Glencorse, Thora A.; Bateson, Alan N.; Hunt, Stephen P.; Darlison, Mark G.

Abstract

We have used sequence-specific oligonucleotide probes and in situ hybridisation histochemistry to examine the distributions of the GABAA receptor α1- and γ2-subunit mRNAs in serial sections of 1-day-old chick brain. Both transcripts are present together, at high levels, in many brain regions. Differences are found, however, in the relative amounts of these mRNAs in two isthmic nuclei of the optic lobe, the deep cerebellar nuclei, and the dorsal thalamus. We therefore conclude that while the α1 and γ2 subunits predominantly occur together in the same receptor complex, they may also be found separately in other GABAA receptor subtypes.

Citation

Glencorse, T. A., Bateson, A. N., Hunt, S. P., & Darlison, M. G. (1991). Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain. Neuroscience Letters, 133(1), 45-48. https://doi.org/10.1016/0304-3940%2891%2990053-v

• Journal Article Type: Article
• Acceptance Date: Nov 1, 1991
• Publication Date: 1991-11
• Deposit Date: Aug 5, 2016
• Journal: Neuroscience Letters
• Print ISSN: 0304-3940
• Electronic ISSN: 0304-3940
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 133
• Issue: 1
• Pages: 45-48
• DOI: https://doi.org/10.1016/0304-3940%2891%2990053-v
• Keywords: γ-Aminobutyric acidA receptor, Chick brain,Gene expression, In situ hybridisation, Ligand-gated ion channel, mRNA localisation, Receptor subtype composition,
• Public URL: http://researchrepository.napier.ac.uk/Output/327959