Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis

Donnellan, Samantha; Giardiello, Marco

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes the most human deaths than any other diseases from a single infectious agent. Treatments are long and costly and have many associated side effects. Intracellular bacilli are slow growing and difficult to target, which is augmenting the emergence of multi‐drug resistance. A hallmark trait of TB is the formation of granulomas, chronic cellular aggregates, which limit bacterial growth but provides a survival reservoir where bacilli may disseminate from. Targeting intracellular Mtb is challenging, but nanomedicine may offer a solution. Nanomedicine is a significantly growing research area and offers the potential for specific disease targeting, dosage reduction, and intracellular drug delivery. This review discusses the application of the various forms of nanomedicine towards targeting of Mtb.

Citation

Donnellan, S., & Giardiello, M. (2019). Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis. Journal of Interdisciplinary Nanomedicine, 4(3), 76-85. https://doi.org/10.1002/jin2.61

• Journal Article Type: Review
• Acceptance Date: May 14, 2019
• Online Publication Date: Jul 9, 2019
• Publication Date: 2019-09
• Deposit Date: Feb 11, 2021
• Publicly Available Date: Feb 11, 2021
• Journal: Journal of Interdisciplinary Nanomedicine
• Print ISSN: 2058-3273
• Electronic ISSN: 2058-3273
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 3
• Pages: 76-85
• DOI: https://doi.org/10.1002/jin2.61
• Keywords: drug targeting, infectious disease, nanomedicine, nanoparticles, tuberculosis
• Public URL: http://researchrepository.napier.ac.uk/Output/2718383